Angle closure and India

Sood, Devindra; Sood, NN

doi:10.4103/0301-4738.27063

Cited by 9 publications

(12 citation statements)

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“…[1] As per the current statistical estimates, there are about 12 million glaucoma patients in India, and approximately 12.8% of the country’s blindness can be ascribed to it. [2]…”

mentioning

confidence: 99%

Efficacy of bimatoprost 0.03% in reducing intraocular pressure in patients with 360° synechial angle-closure glaucoma: A preliminary study

Vyas

Naik

Gangaiah

2011

Indian J Ophthalmol

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Context:Peripheral anterior synechiae (PAS; synechiae anterior to functional trabecular meshwork) formation in primary angle-closure glaucoma (PACG) hampers access to uveoscleral outflow. Thus, the role of bimatoprost in such patients with 360° synechiae was evaluated.Aims:To assess efficacy and safety profile of bimatoprost 0.03% in lowering intraocular pressure (IOP) in 360° synechial angle-closure glaucoma patients.Settings and Design:This was a prospective, non-randomized, non-comparative, selective analysis, single-center pilot study.Materials and Methods:A total of 23 eyes of 20 Indian chronic angle-closure glaucoma (CACG) patients with IOP greater than 21 mmHg, 360° PAS and no visual potential in the study eye underwent detailed eye examination. Baseline IOP was measured and YAG peripheral iridotomy was performed for complete angle-closure reconfirmation. Bimatoprost 0.03% was administered for 8 weeks as once-daily evening dose. IOP reduction within treatment group was determined with “paired t-test”.Results:The mean reduction in IOP from baseline to 8 weeks of bimatoprost therapy was 15.3 ± 9.5 mmHg (P < 0.001). The most commonly observed adverse event was conjunctival hyperemia (35%). Bimatoprost was well tolerated in the study.Conclusions:In this study, exclusively involving patients with 360° synechial angle-closure glaucoma and no visual potential, bimatoprost 0.03% treatment demonstrated a statistically significant IOP reduction. Hence, it can be inferred that bimatoprost 0.03% is an efficacious treatment modality in this subgroup of patients for reducing IOP.

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“…[1] As per the current statistical estimates, there are about 12 million glaucoma patients in India, and approximately 12.8% of the country’s blindness can be ascribed to it. [2]…”

mentioning

confidence: 99%

Efficacy of bimatoprost 0.03% in reducing intraocular pressure in patients with 360° synechial angle-closure glaucoma: A preliminary study

Vyas

Naik

Gangaiah

2011

Indian J Ophthalmol

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“…Sometimes its juice is also being given in vomiting and dysentery. Some workers also reported this plant to have flea repellent (Sood et al, 1966), as well as calcium blocking activity (Yamaha et al, 1987).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial activity of Boenninghausenia albiflora Reichb. (Rutaceae)

Khulbe¹,

Sati²

2009

Afr. J. Biotechnol.

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Various organic and aqueous extracts of aerial part of Boenninghausenia albiflora (Rutaceae) obtained by infusion and maceration were screened for their antimicrobial activity against eight animal and plant pathogenic bacteria (Bacillus subtilis, Staphylococcus aureus, Erwinia chrysanthemi, Escherichia coli, Proteus vulgaris, Xanthomonas phaseoli, Agrobacterium tumefaciens and Xanthomonas campestris) using disc diffusion method. Out of total 32 tests performed, 27 tests showed positive antibacterial activity at 1000 µ µ µ µg/ml concentration, whereas 15 instances exhibited zone of inhibition ≥ ≥ ≥ ≥ 10 mm at same concentration. The activity shown by some of the extracts was found higher than ampicillin (10 mcg) and erythromycin (15 mcg), standard antibiotic used.

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“…(2) Asians are most affected by PACG, while in the western world open angle glaucoma is more prevalent. (3) It is estimated that by the year 2020, there would be 79.6 millions people affected with glaucoma 47% of the glaucoma worldwide would be in Asia with more than 75% being angle closure. (4) At present 12 million Indians are affected by glaucoma accounting for 12.8% of the blindness in the country.…”

Section: Introductionmentioning

confidence: 99%

“…(8) Primary angle closure suspect (Occludable angle), Primary Angle Closure (PAC) and PACG are now distinct entities reflecting the severity of the disease. (3) Primary angle closure glaucoma is a condition in which elevation of IOP occurs as a result of obstruction of aqueous outflow by partial or complete closure of the angle by peripheral iris. The diagnosis depends largely on examination of anterior segment and careful gonioscopy.…”

Section: Introductionmentioning

confidence: 99%