Efficacy of bimatoprost 0.03% in reducing intraocular pressure in patients with 360° synechial angle-closure glaucoma: A preliminary study

Vyas, Prateep; Naik, Uday; Gangaiah, Jayasheel B

doi:10.4103/0301-4738.73708

Cited by 9 publications

(3 citation statements)

References 22 publications

(34 reference statements)

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“…IOP is especially important for treating glaucoma. Although intraocular hypertension is not a requirement, it is still a significant risk factor in the development of glaucoma treatment ( 7 , 8 ). Lowering the IOP level is also the only effective treatment means to control the development of glaucoma in clinical practices.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the iCare rebound tonometer and the Goldmann applanation tonometer

Gao

Liu

Zhao

et al. 2017

Experimental and Therapeutic Medicine

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Tonometry is a fundamental procedure in routine ophthalmologic examination. Although regarded as the reference standard, the Goldmann applanation tonometer (GAT) has its limitations. A new portable alternative to the GAT is the iCare rebound tonometer (RT). The aim of the present study was to compare the intraocular pressure (IOP) results obtained using the RT and GAT and then correlate the results with the central corneal thickness (CCT). Moreover, the tolerability and safety of the RT were evaluated. The IOP of 336 patients (672 eyes) was determined by the RT and GAT. The patients were divided into three groups (group A, 7–15 mmHg, n=74; group B, 16–22 mmHg, n=218; and group C, 23–50 mmHg, n=44), based on the GAT IOP readings. Pachymetry and slit lamp inspection were also performed. To establish an agreement between the devices, a Bland-Altman analysis and paired t-test were performed. The correlation between CCT and IOP readings obtained by the two devices were assessed using linear regression correlation analysis. The mean IOP values of the RT and the GAT were 18.30±5.10 and 18.52±4.46 mmHg, respectively. There were no significant differences between them (t=−1.31, P=0.19). The 95% confidence interval of the differences between the two devices was −5.80–6.24 mmHg. The RT readings are correlated well with those of GAT (r=0.806, P=0.001). However, the RT measurements were significantly (t=−2.84, P=0.007) lower (−1.66±3.87 mmHg) than those obtained with GAT when GAT ≥23 mmHg. Both the RT (r=0.390, P=0.001) and the GAT (r=0.191, P=0.001) showed positive correlations with CCT. The IOP measurement with RT was well tolerated. None of the corneal epithelial defects was detected and all subjects denied discomfort. The RT is well tolerated and safe, and can be considered a reliable alternative to GAT for patients in a low to moderate IOP range. However, in patients with high IOP values, the measurements obtained with RT did not correlate well with those obtained by GAT. The RT readings are influenced more by CCT compared to GAT.

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Section: Discussionmentioning

confidence: 99%

Comparison of the iCare rebound tonometer and the Goldmann applanation tonometer

Gao

Liu

Zhao

et al. 2017

Experimental and Therapeutic Medicine

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“…About 66.8 million people worldwide are afflicted with glaucoma. 3 An estimated 4.4 million Americans have glaucoma, and over 120,000 of these people are rendered blind as a result. 4 The actual etiology of the condition remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Current primary open-angle glaucoma treatments and future directions

Beidoe

Mousa

2012

OPTH

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Primary open-angle glaucoma (POAG) is a leading cause of blindness with no known cure. Management of the disease focuses on lowering intraocular pressure (IOP) with current classes of drugs like prostaglandin analogs, beta-blockers, alpha-agonists, and carbonic anhydrase inhibitors. These treatments have not helped all patients. Some patients continue to experience deterioration in the optic nerve even though their IOPs are within the normal range. New views have surfaced about other pathophysiological processes (such as oxidative stress, vascular dysfunction, and retinal cell apoptosis) being involved in POAG progression, and adjunctive treatments with drugs like memantine, bis(7)-tacrine, nimodipine, and mirtogenol are advocated. This review examines the current and proposed treatments for POAG. Some of the proposed drugs (bis(7)-tacrine, nimodipine, vitamin E, and others) have shown good promise, mostly as monotherapy in various clinical trials. It is recommended that both the current and proposed drugs be put through further robust trials in concurrent administration and evaluated.

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“…with great interest and applaud them for their lucid presentation. [ 1 ] There are precious few studies on the efficacy of prostaglandin analogues, especially in angle-closure glaucoma. We take this opportunity to put forth our observations on the subject based on our experiences with patients suffering from similar conditions.…”

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confidence: 99%