Angka Kejadian, Lama Rawat, dan Mortalitas Pasien Acute Kidney Injury di ICU RSUP Dr. Hasan Sadikin Bandung

Wang, Li; Pradian, Erwin; Kestriani, Nurita Dian

doi:10.15851/jap.v8n2.2054

Cited by 4 publications

(3 citation statements)

References 21 publications

(29 reference statements)

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“…A study carried out from September 2019 to February 2020 (n=148 ICU patients) reported that 52.5% were diagnosed with stage-3 AKI and the mortality rate was 77%. 12 AKI was also observed in COVID-19 patients. In Saudi Arabia, the incidence of AKI in hospitalized patients with COVID-19 was 36% related to higher 30-day mortality.…”

Section: Introductionmentioning

confidence: 79%

The Nephroprotective Activity of Boesenbergia Rotunda Rhizome by Reducing Creatinine, Urea Nitrogen, Glutamic Pyruvic Transaminase, and Malondialdehyde Levels in the Blood and Attenuating the Expression of Havcr1 (KIM-1), Lcn2 (NGAL), Casp3, and Casp7 Genes in the Kidney Cortex of Cisplatin-Induced Sprague-Dawley Rats

Sujana,

Sumiwi,

Saptarini

et al. 2024

JEP

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Background: Cisplatin chemotherapy induces nephrotoxicity by producing reactive oxygen species, hence, discovering add-on nephroprotective drugs for patients with cancer is challenging. Boesenbergia rotunda has been reported for its antioxidant properties. Purpose: This study aims to explore the nephroprotective mechanism of the ethanol extract of Boesenbergia rotunda rhizome (EEBR) in cisplatin-induced rats. Methods: The rats were randomly assigned into 6 groups: the normal control (treated with saline); the negative control (cisplatininduced without any treatment); the positive control (treated with quercetin 50 mg/kg BW); and 3 treatment EEBR (125 mg/kg BW; 250 mg/kg BW; 500 mg/kg BW) groups for 10 days. The % relative organ weight, kidney histopathology, and nephrotoxicity biomarkers expression were evaluated. Results: EEBR decreased creatinine, urea nitrogen, glutamic pyruvate transaminase, and malondialdehyde levels in the blood of cisplatin-induced rats. An insignificant increase in GOT was observed in rats treated with the highest dose of EEBR. EEBR did not significantly alter the BW and the % kidney relative weight. An abnormal shape of the Bowman capsule is observed in the negative control group. EEBR reduced the expression of Havcr1 (KIM-1), Lcn2 (NGAL), Casp3, and Casp7 genes in rats' kidneys. Conclusion: Boesenbergia rotunda could be considered a potential candidate for add-on therapy in cisplatin-treated patients, but further studies are needed to verify its efficacy and safety.

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Section: Introductionmentioning

confidence: 79%

The Nephroprotective Activity of Boesenbergia Rotunda Rhizome by Reducing Creatinine, Urea Nitrogen, Glutamic Pyruvic Transaminase, and Malondialdehyde Levels in the Blood and Attenuating the Expression of Havcr1 (KIM-1), Lcn2 (NGAL), Casp3, and Casp7 Genes in the Kidney Cortex of Cisplatin-Induced Sprague-Dawley Rats

Sujana,

Sumiwi,

Saptarini

et al. 2024

JEP

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“…For this reason, it is emphasized that AKI should be prevented in various ways [14]. Another study in Indonesia also found that AKI was significantly associated with mortality in ICU patients [15,16].…”

Section: Discussionmentioning

confidence: 99%

Clinical Profile and Outcome of Critically Ill Post COVID-19 Patients in The Non COVID-19 Intensive Care Unit of a Tertiary Hospital in Indonesia

Lilihata¹,

Semedi²,

Andriyanto³

2022

IJRP

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Background: Survival rates of severe COVID-19 has increased. Despite that COVID-19 appears to leave sequelae, hence the need of critical care and mortality after prolonged treatment. There were not many studies which investigated critically ill post COVID-19 patients. This study aimed to analyze clinical profiles and their relationship to outcomes of critically ill post-COVID-19 patients in a regular (non COVID-19) ICU at a tertiary hospital in Indonesia. Materials and methods: This single-centre, retrospective study was conducted at Dr. Soetomo General Hospital, Indonesia between March 1st and October 31st, 2021 with total sampling method. Subjects were post COVID-19 patients from the COVID-19 ICU and ward who have been declared RT-PCR negative twice but require further intensive care in the regular ICU. Bivariate analysis was performed using chi-square, Mann-Whitney, and independent t-test. Multivariate analysis was carried out by logistic regression. The results were considered significant when p<0.05. Results:The study included 76 critically ill patients who had completed their COVID-19 treatment in the COVID-19 ward or COVID-19 ICU and required further intensive care. Bivariate analysis shwed obesity (p 0.047), CNS disease (p 0.038), complications in the form of sepsis (p 0.002), secondary infection (p 0.001), and the presence of MDRO (p 0.017) were significantly associated with mortality. Multivariate analysis showed risk factors of mortality were complications that were AKI, cardiac complications, secondary infection, sepsis and non COVID-19 ICU LOS. Conclusion: Complications AKI, cardiac complications, sepsis, and secondary infection were risk factors for mortality in critically ill post COVID-19 patients in the ICU.

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“…Simpulan, angka kejadian AKI di ICU RSUP Dr. Hasan Sadikin Bandung tergolong tinggi, yaitu 41,2% serta mortalitas yang juga tinggi, yaitu 77%. 2 Dalam studi yang baru-baru ini diterbitkan, Doi et al meneliti peran prognostik Renal Resistive Index (RRI) selama 3,1 tahun pada kelompok 426 pasien dengan hipertensi primer dan tidak ada penyakit kardiovaskular sebelumnya. 3 RRI terbukti menjadi prediktor independen untuk mengetahui outcome kardiovaskular dan ginjal yang lebih buruk, terutama bila dikombinasikan dengan penurunan Glomerular Filtration Rate (GFR), sehingga memberikan pelengkap diagnostik yang berguna untuk penilaian fungsi ginjal pada pasien ini.…”

Section: Acuteunclassified

Korelasi Renal Resistive Index dengan Kejadian Acute Kidney Injury

Bejo Utomo Handayani,

Lubis,

Tanjung

2024

MACC

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Pendahuluan: Acute Kidney Injury (AKI) merupakan sindrom klinis akibat penurunan fungsi ginjal yang disebabkan berbagai etiologi seperti azotemia pre-renal, nekrosis tubular akut, nefritis interstisial akut, penyakit glomerulus dan vaskulitis akut ginjal, serta nefropati obstruktif post-renal. Penelitian ini bertujuan untuk menganalisa korelasi penggunaan Renal Resistive Index (RRI) dengan kejadian AKI pada pasien kritis yang dirawat di Intensive Care Unit (ICU) RSUP Haji Adam Malik Medan. Metode: Penelitian ini merupakan uji observasional dengan metode cross-sectional survey Hasil: Berdasarkan hasil analisa didapatkan data sebesar 55% subjek penelitian dengan nilai RRI > 0,7 dan terdapat korelasi yang cukup antara RRI nilai kreatiniin dengan nilai r 0,363. RRI memiliki sensitivitas 91,66%, spesifisitas 62,5%, dan akurasi 80% dengan nilai prediksi positif 78,57% dan nilai prediksi negatif 83,33%. Dengan demikian RRI memiliki AUROC = 0,771 dengan interval kepercayaan sebesar 95%. Kesimpulan: Terdapat korelasi yang cukup antara RRI dengan kejadian AKI pada pasien kritis yang dirawat di ruang ICU RSUP Haji Adam Malik Medan.

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Angka Kejadian, Lama Rawat, dan Mortalitas Pasien Acute Kidney Injury di ICU RSUP Dr. Hasan Sadikin Bandung

Cited by 4 publications

References 21 publications

Clinical Profile and Outcome of Critically Ill Post COVID-19 Patients in The Non COVID-19 Intensive Care Unit of a Tertiary Hospital in Indonesia

Korelasi Renal Resistive Index dengan Kejadian Acute Kidney Injury

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