Angiotensin receptor blockers: Focus on cardiac and renal injury

Arumugam, Somasundaram; Sreedhar, Remya; Thandavarayan, Rajarajan Amirthalingam; Karuppagounder, Vengadeshprabhu; Krishnamurthy, Prasanna; Suzuki, Kenji; Nakamura, Masahiko; Watanabe, Kenichi

doi:10.1016/j.tcm.2015.06.004

Cited by 36 publications

(36 citation statements)

References 38 publications

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“…Ang II mediated by renin is a potent vasopressor. This hormone plays an important role in the pathogenesis of atherosclerosis and hypertension . Consequently, JCTs mainly cause grade 3 hypertension.…”

Section: Discussionmentioning

confidence: 99%

Preoperative Diagnosis of Juxtaglomerular Cell Tumors in Eight Patients

Kang

Chen

Zhong

et al. 2016

J of Clinical Hypertension

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The aim of this study was to improve the diagnostic efficiency for juxtaglomerular cell tumors (JCTs) and to determine whether clinical and magnetic resonance imaging features can help to differentiate JCTs from clear cell renal cell carcinoma (ccRCC). The clinical features of eight patients with JCTs and 27 patients with ccRCCs were analyzed. A flow diagram for young people with hypertension was applied to facilitate the diagnosis. Clinical presentations were analyzed, including age, hypertension, and hypokalemia. The results of our study produced a flow diagram that narrowed the scope of diagnosis. The statistical results demonstrated that patients with a renal mass aged 14 to 30 years, had grade 3 hypertension, or had moderate hypokalemia had a greater possibility of having a JCT than a ccRCC (P<.0000, P<.01, P<.0005, respectively). In addition, the flow diagram and magnetic resonance imaging features were useful to distinguish JCTs from other renal tumors.

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Section: Discussionmentioning

confidence: 99%

Preoperative Diagnosis of Juxtaglomerular Cell Tumors in Eight Patients

Kang

Chen

Zhong

et al. 2016

J of Clinical Hypertension

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“…Abnormal expression of AT1R at the cell surface has been well described to significantly contribute to the development of many cardiovascular diseases and cancers and AT1R blockers are important drugs for the treatment of these diseases [6, 58, 59]. Although molecular mechanisms governing the cell surface export of AT1R are not well understood, recent studies have demonstrated that it is coordinated by many regulatory proteins, motif-mediated interaction with transport machineries and structural determinants [28, 30–33].…”

Section: Discussionmentioning

confidence: 99%

A single mutation in helix 8 enhances the angiotensin II type 1a receptor transport and signaling

Zhu

Zhang

Davis

et al. 2015

Cellular Signalling

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The amphipathic helix 8 in the membrane-proximal C-terminus is a structurally conserved feature of class A seven transmembrane-spanning G protein-coupled receptors (GPCRs). Mutations of this helical motif often cause receptor misfolding, defective cell surface transport and dysfunction. Surprisingly, we demonstrated here that a single point mutation at Lys308 in helix 8 markedly enhanced the steady-state surface density of the angiotensin II type 1a receptor (AT1aR). Consistent with the enhanced cell surface expression, Lys308 mutation significantly augmented AT1aR-mediated mitogen-activated protein kinase ERK1/2 activation, inositol phosphate production, and vascular smooth muscle cell migration. This mutation also increased the overall expression of AT1aR without altering receptor degradation. More interestingly, Lys308 mutation abolished AT1aR interaction with β-COP, a component of COPI transport vesicles, and impaired AT1aR responsiveness to the inhibition of Rab6 GTPase involved in the Golgi-to-ER retrograde pathway. Furthermore, these functions of Lys308 were largely dependent on its positively charged property. These data reveal previously unappreciated functions of helix 8 and novel mechanisms governing the cell surface transport and function of AT1aR.

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“…Endogenous activated Ang(1-7) also plays a protective role against atherosclerotic plaque vulnerability in apolipoprotein E-deficient mice fed with a high fat diet [16]. Finally, as suggested by Arumugam et al [1], some ARBs including telmisartan and irbesartan also possess peroxisome proliferator-activated receptor gamma (PPARγ) agonistic action in addition to its anti-hypertensive property. These ARBs are therefore also effective in improving insulin sensitivity in patients with high blood pressure.…”

mentioning

confidence: 93%