Editorial commentary: A revisit on the renin–angiotensin system in cardiovascular biology

Tian, Xiaoyu; Ma, Shuangtao; Huang, Yu; Wong, Wing Tak

doi:10.1016/j.tcm.2015.06.008

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…The RAS is an important humoral regulatory system in the human body. The RAS functions in the circulation as well as in the blood vessel wall, heart, kidney, adrenal gland, and other tissues and it plays an important role in the normal development of the cardiovascular system, cardiovascular homeostasis, the maintenance of electrolyte and fluid balance, and the regulation of blood pressure [ 82 , 83 ].…”

Section: Renin-angiotensin Systemmentioning

confidence: 99%

Pathogenesis of Chronic Kidney Disease Is Closely Bound up with Alzheimer’s Disease, Especially via the Renin-Angiotensin System

Zheng

Meng

2023

JCM

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Chronic kidney disease (CKD) is a clinical syndrome secondary to the definitive change in function and structure of the kidney, which is characterized by its irreversibility and slow and progressive evolution. Alzheimer’s disease (AD) is characterized by the extracellular accumulation of misfolded β-amyloid (Aβ) proteins into senile plaques and the formation of neurofibrillary tangles (NFTs) containing hyperphosphorylated tau. In the aging population, CKD and AD are growing problems. CKD patients are prone to cognitive decline and AD. However, the connection between CKD and AD is still unclear. In this review, we take the lead in showing that the development of the pathophysiology of CKD may also cause or exacerbate AD, especially the renin-angiotensin system (RAS). In vivo studies had already shown that the increased expression of angiotensin-converting enzyme (ACE) produces a positive effect in aggravating AD, but ACE inhibitors (ACEIs) have protective effects against AD. Among the possible association of risk factors in CKD and AD, we mainly discuss the RAS in the systemic circulation and the brain.

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Section: Renin-angiotensin Systemmentioning

confidence: 99%

Pathogenesis of Chronic Kidney Disease Is Closely Bound up with Alzheimer’s Disease, Especially via the Renin-Angiotensin System

Zheng

Meng

2023

JCM

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“…e renin-angiotensin system (RAS) is critical in maintaining homeostasis of the cardiovascular system [1]. In the classical RAS axis, juxtaglomerular cells of the kidney release renin which catalyzes angiotensinogen cleavage to form the glycopeptide angiotensin I. Angiotensin I is converted to angiotensin II by the angiotensin-converting enzyme (ACE) which removes the two terminal peptides from angiotensin I. Angiotensin II (Ang II) is the main peptide formed in this classical RAS axis and binds to angiotensin type-1 receptor (AT1R) and angiotensin type-2 receptor (AT2R) [2].…”

Section: Introductionmentioning

confidence: 99%

Physiological and Biochemical Vascular Reactivity Parameters of Angiotensin II and the Action of Biased Agonist TRV023

Leal

Almeida

Torres

et al. 2020

Advances in Pharmacological and Pharmaceutical Sciences

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Vascular reactivity experiments using isolated aortic rings have been widely used as a model for physiological and pharmacological studies since the early sixties. Here, we suggest several parameters that the researcher should pay attention to when investigating angiotensin II in their experimental models. Angiotensin II is one of the active peptides of the renin-angiotensin system and exerts its effect through the AT1 and AT2 receptors. Some studies seek to understand the effects of angiotensin II receptors at the vascular level by using vascular reactivity experiments. However, because of the large number of variations, there are only a handful of reactivity studies that seek to use this method. Thus, the objective of this study was to standardize experimental methods with angiotensin II, through vascular reactivity protocols. For this, variables such as basal tension, concentration interval, single concentration, curve concentration response, and multiple experiments using the same aortic ring were developed using the technique of vascular reactivity in an organ bath. This is the first study that has standardized the vascular reactivity protocol. In addition, we demonstrated the effects of TRV023-biased ligand of the AT1R at vascular sites.

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Editorial commentary: A revisit on the renin–angiotensin system in cardiovascular biology

Cited by 2 publications

References 18 publications

Pathogenesis of Chronic Kidney Disease Is Closely Bound up with Alzheimer’s Disease, Especially via the Renin-Angiotensin System

Pathogenesis of Chronic Kidney Disease Is Closely Bound up with Alzheimer’s Disease, Especially via the Renin-Angiotensin System

Physiological and Biochemical Vascular Reactivity Parameters of Angiotensin II and the Action of Biased Agonist TRV023

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