NF-jB to enter the nucleus and initiate transcription. Collectively, these events lead to reduced synthesis of proinflammatory cytokines and of cyclooxygenase 2 (COX-2), the enzyme that mediates synthesis of proinflammatory prostaglandins.Key Points related to Section III.C on intracellular signaling are:• The intracellular signaling pathways coupled to this atypical GPCR are equally atypical and very different from the canonical GPCR-mediated signaling events.