Angiotensin-(1–9) in hypertension

Norambuena-Soto, Ignacio; López-Crisosto, Camila; Martinez-Bilbao, Javiera; Hernández‐Fuentes, Carolina; Parra, Valentina; Lavandero, Sergio; Chiong, Mario

doi:10.1016/j.bcp.2022.115183

Cited by 8 publications

(3 citation statements)

References 180 publications

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“…Upregulation of the ACE2/Ang1-7/MasR axis also improved bone metabolism, mineralization, and mass and reduced RANKL expression which can be increased by Ang II stimulation [55]. A growing number of studies are also evidencing the anti-hypertensive and anti-remodeling role of Ang 1-9 in vascular, renal, and cardiac function [59]. Below, we focused on the evidence supporting the beneficial role of the ACE2/Ang1-7/MasR and Ang 1-9 in cardiac and renal function and remodeling.…”

Section: Organ Damagementioning

confidence: 97%

“…Another important evidence by Flores-Munos [58] reported that Ang 1-9 specifically binds to AT2R, antagonizing the Ang II signaling in cardiomyocytes and underlining the role of this peptide in the protective branch of RAAS. Nowadays, it is well known that Ang 1-9 plays an anti-hypertensive and anti-remodeling role by inducing vasodilation, improving renal function, increasing eNOS levels and NO production, and lowering inflammation [59]. An overview of ACE2, Ang 1-7/MasR, and Ang 1-9 effects is provided below.…”

Section: Ace2/ang 1-7/masr Axis and Ang 1-9mentioning

confidence: 99%

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The RAAS Goodfellas in Cardiovascular System

Caputo,

Bertoldi,

Driussi

et al. 2023

JCM

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In the last two decades, the study of the renin–angiotensin–aldosterone system (RAAS) has revealed a counterregulatory protective axis. This protective arm is characterized by ACE2/Ang 1-7/MasR and Ang 1-9 that largely counteracts the classic arm of the RAAS mediated by ACE/Ang II/AT1R/aldosterone and plays an important role in the prevention of inflammation, oxidative stress, hypertension, and cardiovascular remodeling. A growing body of evidence suggests that enhancement of this counterregulatory arm of RAAS represents an important therapeutic approach to facing cardiovascular comorbidities. In this review, we provide an overview of the beneficial effects of ACE2, Ang 1-7/MasR, and Ang 1-9 in the context of oxidative stress, vascular dysfunction, and organ damage.

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Section: Organ Damagementioning

confidence: 97%

Section: Ace2/ang 1-7/masr Axis and Ang 1-9mentioning

confidence: 99%

The RAAS Goodfellas in Cardiovascular System

Caputo,

Bertoldi,

Driussi

et al. 2023

JCM

View full text Add to dashboard Cite

show abstract

“…Likewise, the results obtained from animals and preclinical studies are also specious. However, the Ang (1-9)-AT2R axis remains a potential therapeutic target for the treatment of hypertension if the current obstacles can be overcome by focusing on the local synthesis of Ang (1-9), enhancing its stability, or synthesizing small-molecule AT2R agonists [412] .…”

Section: Targeting Counter-regulatory Ras In Hypertensionmentioning

confidence: 99%