Angiotensin I converting enzyme in the ejaculate of fertile and infertile men

Hohlbrugger, G.; Pschorr, Johanna; Dahlheim, H.

doi:10.1016/s0015-0282(16)47614-4

Cited by 29 publications

(15 citation statements)

References 5 publications

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“…Both ACE and prorenin are found in seminal plasma (22)(23)(24)(25). In addition, the presence of angiotensin II type 1 (AT 1 ) receptors in ejaculated rat and human sperm strongly suggested the possibility that angiotensin affects sperm function, and we reported the stimulation by angiotensin II of patterns of motility associated with capacitation in sperm from patients attending a fertility clinic.…”

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confidence: 83%

Synthesis and Secretion of Angiotensin II by the Prostate Gland in Vitro

et al. 2005

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The renin angiotensin system has been shown to have tissuerelated functions that are distinct from its systemic roles. We showed that angiotensin II type 1 (AT 1 ) receptors are present in mammalian sperm, and angiotensin II stimulates sperm motility and capacitation. In addition, angiotensin II is present in human seminal plasma at concentrations higher than found in blood. In testing the possibility that the prostate may be the source of seminal plasma angiotensin II, mRNA coding for angiotensinogen, (pro)renin, and angiotensin-

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confidence: 83%

Synthesis and Secretion of Angiotensin II by the Prostate Gland in Vitro

et al. 2005

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“…ACE enzyme activity is low in immature animals and increases with the onset of sexual maturity (126,314). The ACE activity in semen is enhanced by sexual stimulation (282,313) but is normal in oligospermic men (281). A role of the tACE in capacitation has been suggested by several authors (211,658).…”

Section: Male Reproductive Tractmentioning

confidence: 96%

Physiology of Local Renin-Angiotensin Systems

Paul

Mehr²,

Kreutz³

2006

Physiological Reviews

1,487

1,371

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Since the first identification of renin by Tigerstedt and Bergmann in 1898, the renin-angiotensin system (RAS) has been extensively studied. The current view of the system is characterized by an increased complexity, as evidenced by the discovery of new functional components and pathways of the RAS. In recent years, the pathophysiological implications of the system have been the main focus of attention, and inhibitors of the RAS such as angiotensin-converting enzyme (ACE) inhibitors and angiotensin (ANG) II receptor blockers have become important clinical tools in the treatment of cardiovascular and renal diseases such as hypertension, heart failure, and diabetic nephropathy. Nevertheless, the tissue RAS also plays an important role in mediating diverse physiological functions. These focus not only on the classical actions of ANG on the cardiovascular system, namely, the maintenance of cardiovascular homeostasis, but also on other functions. Recently, the research efforts studying these noncardiovascular effects of the RAS have intensified, and a large body of data are now available to support the existence of numerous organ-based RAS exerting diverse physiological effects. ANG II has direct effects at the cellular level and can influence, for example, cell growth and differentiation, but also may play a role as a mediator of apoptosis. These universal paracrine and autocrine actions may be important in many organ systems and can mediate important physiological stimuli. Transgenic overexpression and knock-out strategies of RAS genes in animals have also shown a central functional role of the RAS in prenatal development. Taken together, these findings may become increasingly important in the study of organ physiology but also for a fresh look at the implications of these findings for organ pathophysiology.

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“…The activity of the ACE enzyme is low in immature mammals and increases with the onset of sexual maturity [42,49]. Sexual stimulation was shown to enhance ACE activity in semen [50,51] but remains basal in oligospermic males [50]. The ACE enzyme may play a role in fertilization, since its levels increase during sperm capacitation [52][53][54][55].…”

Section: Role In Male Reproductionmentioning

confidence: 99%

Renin-Angiotensin System on Reproductive Biology

Castilho¹,

Fontes²,

Franchi³

et al. 2017

Renin-Angiotensin System - Past, Present and Future

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In the female reproductive system, angiotensin II (ANG II) is a potential signaling molecule involved in ovarian follicle development, which acts through two transmembrane receptors. Within the ovarian follicle, there appear to be species differences in the precise pattern of localization of AGTR2 protein and it has an important role in in vitro maturation of oocytes in mammals. The infusion of ANG II induced ovulation in rabbits and the use of ANG II antagonists inhibited ovulation in rabbits, rats, and cattle. In fetal ovaries, AGTR2 protein was detected in ovigerous cords and preantral follicles throughout porcine and bovine gestation. In the oviduct, ANG II is responsible for the orchestration of the transport of gametes. In the male reproductive system, there is considerable evidence for the local synthesis of components of renin-angiotensin system (RAS) in male reproductive tissues. The roles of RAS in local processes at these sites are still uncertain, although there is evidence for involvement in tubular contractility, spermatogenesis, sperm maturation, capacitation, acrosomal exocytosis, and fertilization.

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Angiotensin I converting enzyme in the ejaculate of fertile and infertile men

Cited by 29 publications

References 5 publications

Synthesis and Secretion of Angiotensin II by the Prostate Gland in Vitro

Synthesis and Secretion of Angiotensin II by the Prostate Gland in Vitro

Physiology of Local Renin-Angiotensin Systems

Renin-Angiotensin System on Reproductive Biology

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