Angiotensin‐converting enzyme polymorphisms and risk of spontaneous deep intracranial hemorrhage in Taiwan

Abstract

This study demonstrates that environmental risk factors play a major role and ACE polymorphisms play a minor role in contributing risk of SDICH in Taiwan.

Angiotensin-converting enzyme tag single nucleotide polymorphisms in patients with intracerebral hemorrhage

“…An insertion/deletion (I/D) polymorphism of ACE gene (rs4646994) has been linked to several diseases including atherosclerosis [12], Alzheimer's disease [13], and ICH [14][15][16][17][18][19], sometimes with conflicting results. Slowik et al [14] first noticed that ACE DD genotype increased the risk of nonlobar ICH [odds ratio (OR) 2.46, 95% confidence interval (CI) 1.14-5.31, P = 0.02].…”

Angiotensin-converting enzyme insertion/deletion gene polymorphism and risk of intracranial aneurysm in a Chinese population

“…[41][42][43][44] ACE I/D polymorphisms have also been extensively studied in several cardiovascular adult diseases, such as thoracic aortic dissection, 45 ischaemic stroke, 13 coronary heart disease, 14,46 left ventricular hypertrophy 47 and intracerebral haemorrhage. [15][16][17][18][19][20] In conclusion, data from the present study suggest that the ACE DD genotype may be a protective factor against IA in a Chinese population. A larger, multicentre study, which is statistically powered to detect differences in the risk of IA between different ACE genotypes, is required in order to confirm the present results.…”

“…11,12 These polymorphisms have, therefore, been extensively studied in several adult cardiovascular diseases including ischaemic stroke, 13 coronary heart disease 14 and intracerebral haemorrhage. [15][16][17][18][19][20] Until now, the relationship between ACE I/D polymorphisms and IA has only been studied in Caucasian populations and in a single study from Japan. [20][21][22][23][24] The aim of the present hospital-based, case-control study was to investigate the association between ACE I/D polymorphisms and the risk of IA in a Chinese population.…”

Angiotensin-converting enzyme insertion/deletion gene polymorphisms and risk of intracerebral hemorrhage: A meta-analysis of epidemiologic studies

“…[25][26][27][28][29][30][31][32][33] Finally, a total of six studies were included in our meta-analysis, which included 744 ICH cases and 1411 controls. [19][20][21][22][23][24] Study characteristics are summarized in Table 1. Of those, one study included population-based case-control studies, and five studies included hospitalbased case-control studies.…”

“…Through the step of screening the title and abstracts, 83 articles were excluded, leaving 15 articles for full publication review. [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] Of these, nine were excluded. [25][26][27][28][29][30][31][32][33] Finally, a total of six studies were included in our meta-analysis, which included 744 ICH cases and 1411 controls.…”