2001
DOI: 10.1136/pmj.77.904.114
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Angiotensin converting enzyme inhibitor induced hyperkalaemic paralysis

Abstract: Secondary hyperkalaemic paralysis is a rare condition often mimicking the Guillain-Barré syndrome. There have been a few case reports of hyperkalaemia caused by renal failure, trauma, and drugs where the presentation has been with muscle weakness. A case of hyperkalaemic paralysis caused by an angiotensin converting enzyme inhibitor is reported.

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Cited by 19 publications
(7 citation statements)
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“…5 One case report described hyperkalemiainduced paralysis in a 78-year-old man that was presumably due to enalapril. 6 Consistent with these reports, our patient was experiencing renal insufficiency and receiving an angiotensinconverting enzyme inhibitor (lisinopril) and a nonsteroidal antiinflammatory drug (naproxen). In the case reports, potassium levels ranged from 8.1-9.2 mEq/L.…”
Section: Discussionsupporting
confidence: 82%
“…5 One case report described hyperkalemiainduced paralysis in a 78-year-old man that was presumably due to enalapril. 6 Consistent with these reports, our patient was experiencing renal insufficiency and receiving an angiotensinconverting enzyme inhibitor (lisinopril) and a nonsteroidal antiinflammatory drug (naproxen). In the case reports, potassium levels ranged from 8.1-9.2 mEq/L.…”
Section: Discussionsupporting
confidence: 82%
“…The weakness has been attributed to abnormalities at numerous locations in the motor axis, including the muscle, nerve, and neuromuscular junction. 3,14 However, the mechanism of secondary hyperkalemic paralysis could be similar to that of primary hyperkalemic periodic paralysis, which results from a primary sodium channelopathy in muscle. 4 One possible hypothesis is that the increase in plasma potassium concentration reduces the ratio of intracellular potassium concentration to that of the extracellular fluid, resulting in a persistent relative depolarization in the nerve membrane.…”
Section: Hyperkalemia Is a Cause Of Acute Flaccid Paralysis In Patienmentioning
confidence: 99%
“…While primary hyperkalemic paralysis is secondary to a defective sodium channel, a number of aetiologies have been reported as leading to secondary hyperkalemic paralysis. The primary aetiology could be one of renal failure [ 1 ], Addison's disease [ 2 , 3 ], potassium sparing diuretics [ 4 ], potassium supplements, and dietary excess [ 5 ]. Coconut water, when consumed in excess, has been reported to cause severe hyperkalemia [ 6 ].…”
Section: Introductionmentioning
confidence: 99%