Angiotensin-converting enzyme gene polymorphism and risk of insulin resistance in PCOS

Çelik, Önder; Yeşilada, Elif; Hasçalık, Şeyma; Çelik, Nilüfer; Şahin, İ̇brahim; Keskin, Lezzan; Özerol, Elif

doi:10.1016/j.rbmo.2009.12.014

Cited by 23 publications

(27 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A meta-analysis by Niu et al 30 showed that the D allele was associated with susceptibility to type 2 diabetes. One study by Celik et al 31 showed that the DD genotype was associated with an increased insulin resistance in women with polycystic ovary syndrome. A study by You et al 32 showed that the D allele was closely associated with reduced highdensity lipoprotein cholesterol levels.…”

Section: Discussionmentioning

confidence: 99%

A meta-analysis of the association between angiotensin-converting enzyme insertion/ deletion gene polymorphism and the risk of overweight/obesity

Mao

Huang

2013

J Renin Angiotensin Aldosterone Syst

View full text Add to dashboard Cite

Background and objective:The association between angiotensin-converting enzyme insertion/deletion (ACE I/D) gene polymorphism and the risk of overweight/obesity remains controversial. A meta-analysis was conducted to evaluate the association between ACE I/D gene polymorphism and overweight/obesity susceptibility. Method: All eligible studies were included in this meta-analysis by searching PubMed, Embase and Cochrane databases through April 2013 according to a predefined criteria. Results: Fourteen case-control studies including 3371 cases and 4490 controls were recruited for the analysis of the association between ACE I/D gene polymorphism and overweight/obesity susceptibility. A significant association was observed between DD genotype and overweight/obesity risk in overall populations and Africans (p=0.014 and 0.010, respectively). D allele was associated with the risk of overweight/ obesity in Africans (p=0.026). However, II genotype might not be a protective factor against overweight/obesity risk in overall populations, Africans, Caucasians and Asians. Conclusions: DD genotype is a risk factor for the overweight/obesity susceptibility in overall populations, particularly in Africans. D allele is a risk factor for the overweight/obesity susceptibility in Africans. Further larger studies are needed to confirm our findings.

show abstract

Section: Discussionmentioning

confidence: 99%

A meta-analysis of the association between angiotensin-converting enzyme insertion/ deletion gene polymorphism and the risk of overweight/obesity

Mao

Huang

2013

J Renin Angiotensin Aldosterone Syst

View full text Add to dashboard Cite

show abstract

“…The existence of an association between ACE I/D polymorphism and PCOS is controversial. Several studies reported no contribution of this polymorphism in susceptibility to PCOS, however, few studies did find a relationship with insulin resistance, hyperandrogenism and aggravated clinical manifestations of PCOS [16][17][18]. A recent meta-analysis by Jia Hongxia et al (2012) reported a significant relation between this polymorphism and PCOS risk in Caucasians but produced a null result for Asians [15].…”

Section: Discussionmentioning

confidence: 99%

“…To the best of our knowledge, this is the first study to assess the possible role of ACE I/D polymorphisms in the aetiopathogenesis of PCOS. [16,18,26].…”

Section: Discussionmentioning

confidence: 99%

“…To date, most of the studies conducted on PCOS patients from various ethnic groups differ in their reports [15]. Controversial reports of this polymorphism with the clinical manifestations such as insulin resistance and testosterone levels among the PCOS patients were also reported [16][17][18]. There are no studies available from Indian population pertaining to ACE I/D gene polymorphism in relation to PCOS susceptibility and its clinical manifestations.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Do ACE I/D gene polymorphism serve as a predictive marker for age at onset in PCOS?

Deepika

Reddy

Rani³

et al. 2012

J Assist Reprod Genet

View full text Add to dashboard Cite

Background Polycystic ovary syndrome (PCOS) is an endocrine disorder exhibiting variable age at onset of clinical features allied with complex diseases in the later life. ACE is a pleiotropic molecule associated with various pathophysiological functions. The present study was aimed to establish the frequency of ACE I/D gene polymorphism in patients and controls and to assess the influence of this polymorphism on anthropometric and various clinical features of the condition. Methods ACE I/D genotyping was carried out in 259 PCOS patients and 315 healthy ultrasound scanned women of South Indian origin.Results The distribution of DD, ID and II genotypes in patients was 39, 37 and 24 %, whereas in the controls it was 31, 51 and 18 % respectively. Significant difference was observed in the genotypic frequency distributions between the patients and controls, however the allelic frequencies did not vary between the groups (p>0.05). Quartile analysis revealed preponderance of DD genotype in the first two quartiles and a linear increase of II genotype from first to the last quartiles. Further, Multiple Logistic regression analysis revealed significant association of ACE I/D gene polymorphism with acanthosis and age at onset (AAO) of the syndrome (p<0.05). Conclusion The present study is the first report to highlight the predisposing role of DD and protective role of ID genotype towards PCOS. Patients with single or double dose of D allele may develop PCOS symptoms at an early age and also significantly associated with acanthosis, a marker of insulin resistance.

show abstract

“…Among the 8 studies imported in the meta-analysis, 6 of them had been covered by Jia et al meta-analysis (13)(14)(15)(16)(17)(18). Analyses were performed in 5 different groups of alleles and genotypes including D vs I (Figures 2, 3), DD vs II (Figures 4, 5), DD+DI vs II (Figures 6, 7), DD vs DI+II (Figures 8, 9), and DI vs DD+II (Figures 10, 11).…”

Section: Resultsmentioning

confidence: 99%

Polycystic Ovary Syndrome is Affected and Protected by DD and DI Genotypes of Angiotensin Converting Enzyme, Respectively: An Update of a Meta-Analysis

Yari¹,

Ali²,

Abbaszadeh³

et al. 2017

International Journal of Women’s Health and Reproduction Scienc

View full text Add to dashboard Cite

IntroductionAngiotensin converting enzyme (ACE) is a renal enzyme catalyzing the conversion of angiotensin 1 to angiotensin 2. This, results in production of the aldosterone resulting in natrium retention and potassium excretion. ACE gene has 3 polymorphic genotypes of II, DI and DD. It has been observed in several studies and meta-analyses that patients with DD genotype are more at risk of renal and cardiovascular diseases. It seems that these effects could be due to hyperactivity of ACE gene in such patients (1,2). In addition to kidneys, ovaries have renin angiotensin system (RAS). The role of this system in ovulation and reproduction is not completely understood (3).Different histopathologic and angiogenic abnormal conditions result in pregnancy complications (4). Polycystic ovary syndrome (PCOS) is one of such conditions resulting in infertility and other complications of women's reproductive system (5). Based on a metaanalysis conducted by Jalilian et al, prevalence of PCOS in Iran was 6.8%, 4.41% and 19.5% based on NIH, ultrasound and Rotterdam criteria, respectively (6). Type 2 diabetes, obesity, metabolic syndrome, hypertension and so on are considered as risk factors of PCOS (7-9). Also metformin is used for the treatment, because of insulin resistance in such patients (10). All of these evidences give us clues that hypertension related genes like ACE my play roles in pathogenesis of PCOS. Of course it is not clear whether this role is associated with renal RAS, ovarian RAS or both.On the occasion of the clues and findings above, we intend to update the only meta-analysis conducted by Jia et al in 2013 on the association of ACE gene polymorphism and risk of PCOS (11). The reason of our attempt to update this meta-analysis was that Jia et al did not find any significant relation in their random-effect model meta-analysis. Materials and MethodsWe searched in databases for relevant keywords in the titles of the articles (Figure 1). Finally we found 8 relevant papers based on our inclusion criteria (similar protocols including similar criteria for their PCOS and control groups). In order to perform this meta-analysis, we used comprehensive meta-analysis version 2 software (Biostat, US). The analysis was done through the P value and sample size of each study using fixed-effect model. Analyses were performed in 5 different groups of allele and genotype comparisons (Table 1). This meta-analysis Abstract Objectives: Angiotensin converting enzyme (ACE) is an important enzyme involved in the physiopathology of renal, cardiovascular and ovarian systems. One of these ACE related diseases is polycystic ovary syndrome (PCOS). Materials and Methods:We intend to update the only meta-analysis written by Jia et al in 2013 on the association of ACE gene polymorphism and risk of PCOS. The reason of our attempt to update this meta-analysis was that they found no significant relation in their meta-analysis. For this aim, we searched in databases for relevant documents. Results: We found 8 relevant papers, 6 of which had bee...

show abstract

Angiotensin-converting enzyme gene polymorphism and risk of insulin resistance in PCOS

Cited by 23 publications

References 30 publications

A meta-analysis of the association between angiotensin-converting enzyme insertion/ deletion gene polymorphism and the risk of overweight/obesity

A meta-analysis of the association between angiotensin-converting enzyme insertion/ deletion gene polymorphism and the risk of overweight/obesity

Do ACE I/D gene polymorphism serve as a predictive marker for age at onset in PCOS?

Polycystic Ovary Syndrome is Affected and Protected by DD and DI Genotypes of Angiotensin Converting Enzyme, Respectively: An Update of a Meta-Analysis

Contact Info

Product

Resources

About