Angiotensin-Converting Enzyme Gene 2350 G/A Polymorphism Is Associated with Left Ventricular Hypertrophy but Not Essential Hypertension

Pan, Min; Zhu, Jianhua; Liu, Zhihua; Jiang, Wenping; Zhichu, Cui; Yu, Xiaohong; Li, Hongmei; Yang, Xiangjun

doi:10.1291/hypres.30.31

Cited by 24 publications

(36 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…23 The AGTR1-A1166C polymorphism had been investigated in many studies in relation to blood pressure, and sometimes in relation to renal failure risk and other risk factors, producing a variety of results. [27][28][29][30][31] However, our study showed no difference between the CKD and control groups on the A1166C polymorphism. The AGTR1-C521T C polymorphism also did not differ greatly in frequency between the CKD and control groups.…”

Section: Discussioncontrasting

confidence: 71%

Gene polymorphisms of angiotensin-converting enzyme and angiotensin II Type 1 receptor among chronic kidney disease patients in a Chinese population

Lin

et al. 2011

J Renin Angiotensin Aldosterone Syst

View full text Add to dashboard Cite

Chronic kidney disease (CKD) is highly prevalent in Taiwan and an increasing number of patients are affected, with a high risk of progression to end-stage renal disease and huge medical expenses. It has been predicted that the presence of hypertension increases with decreasing renal function due to a decrease in sodium excretion and activation of the renin-angiotensin system (RAS). The aim of this study was to investigate the influence of genetic variants of the RAS gene on CKD. We performed a case control association study and genotyped 135 CKD patients and 270 healthy controls among Han Chinese in Taiwan. All subjects were genotyped for angiotensinogen (AGT-M235T, T174M, A-20C), angiotensin-I converting enzyme (ACE-A2350G) and angiotensin II type 1 receptor (AGTR1-A1166C, C573T, C-521T) polymorphisms of RAS genes by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Significant associations were observed in ACE-A2350G and AGTR1-C573T polymorphism between CKD patients and controls. In regard to ACE-A2350G, compared with the AA genotype the GG genotype protected against CKD (adjusted odds ratio [OR] = 0.34; p = 0.01). In regard to AGTR1-C573T, the CT genotype was a risk for CKD compared with the CC genotype (adjusted OR = 1.82; p = 0.03). We conclude that ACE-A2350G and AGTR1-C573T polymorphisms are likely candidate determinants of CKD. KeywordsChronic kidney disease (CKD), angiotensinogen (AGT), angiotensin-I converting enzyme (ACE), angiotensin II type 1 receptor (AGTR1), single nucleotide polymorphism (SNP)

show abstract

Section: Discussioncontrasting

confidence: 71%

Gene polymorphisms of angiotensin-converting enzyme and angiotensin II Type 1 receptor among chronic kidney disease patients in a Chinese population

Lin

et al. 2011

J Renin Angiotensin Aldosterone Syst

View full text Add to dashboard Cite

show abstract

“…More powerful genetic methods, such as affected-sib pair analysis or family-linkage studies, and/or population studies in different ethnic backgrounds, are necessary to clarify this issue. LVH is the most powerful independent risk factor for morbidity and mortality in hypertensive patients (17,18). Studies have suggested that IL-6 may induce a cardiac hypertrophic phenotype by activation of a gp130 receptor (34,35).…”

Section: Discussionmentioning

confidence: 99%

“…The development of left ventricular hypertrophy (LVH) in hypertensive patients has a negative prognostic impact and is associated with cardiovascular morbidity and mortality (17,18). Increased prevalence of LVH was found in hypertensive patients with higher cytokine levels (19), and the IL-6 -174G>C polymorphism was associated with high blood pressure and LVH in hemodialysis patients (20).…”

Section: Introductionmentioning

confidence: 99%

Interleukin-6 -634C>G polymorphism in hypertensive patients with and without left ventricular hypertrophy

Chen

Guo²,

Gao³

et al. 2011

Mol Med Rep

View full text Add to dashboard Cite

Abstract.There is an accumulating body of evidence indicating that inflammation plays a pivotal role in the pathogenesis of cardiovascular disease. interleukin-6 (il-6) is a pleiotropic cytokine secreted by many cells of the immune system, cardiovascular components and adipose tissue, and functions as a mediator of inflammatory response with both pro-and anti-inflammatory properties. Circulating levels of IL-6 differ greatly between individuals due to both genetic and environmental factors. The IL-6 -634C>G polymorphism is common in eastern Asian populations. The aim of the present study was to investigate the association of this polymorphism with essential hypertension (EH) and left ventricular hypertrophy (LVH) in 440 subjects (246 EH patients and 194 controls) from a Han Chinese population. In this study, IL-6 -634C>G genotypes were identified by polymerase chain reaction and restriction digestion in all study participants, and left ventricular mass was assessed by 2-mode echocardiography in 178 untreated EH patients. There was no significant difference in either genotype distribution (p=0.9528) or allele frequency (p=0.7775) between the EH and control groups. In addition, the -634C>G polymorphism had no effect on blood pressure in either the controls or the untreated EH patients. No significant differences in genotype distribution (p=0.7998) or allele frequency distribution (p=0.5468) were found between EH patients with and without LVH. Moreover, the echocardiographic parameters were not statistically different between the CC and CG+GG genotypes. These findings suggest that there is no association of the IL-6 -634C>G polymorphism and EH with LVH in EH patients.

show abstract

“…Вивченню генетичного полі-морфізму ключових компонентів РААС присвячено значну кількість досліджень [1,5,6]. Останнім часом у літературі розглядається вплив поліморфного маркера 2350 A/G гена ангіотензин -перетворюю-чого ферменту (ACE) на перебіг АГ, але наявні дані суперечливі [7,8,13].…”

Section: Elenaltrawneh@gmailcomunclassified

Efficiency Evaluation of the Combination Therapy for Comorbid Arterial Hypertension with Diabetes Mellitus 2 Type Depending on the Genetic Polymorphism of the Angiotensin-Converting Enzyme

Біловол¹,

Бобронникова²,

Al-Trawneh³

2017

Ukr. ž. med. bìol. sportu

View full text Add to dashboard Cite

Angiotensin-Converting Enzyme Gene 2350 G/A Polymorphism Is Associated with Left Ventricular Hypertrophy but Not Essential Hypertension

Abstract: The angiotensin-converting enzyme (ACE) gene (ACE) is one of the most studied candidate genes related to essential hypertension (EH) and left ventricular hypertrophy (LVH).

Cited by 24 publications

References 32 publications

Gene polymorphisms of angiotensin-converting enzyme and angiotensin II Type 1 receptor among chronic kidney disease patients in a Chinese population

Gene polymorphisms of angiotensin-converting enzyme and angiotensin II Type 1 receptor among chronic kidney disease patients in a Chinese population

Interleukin-6 -634C>G polymorphism in hypertensive patients with and without left ventricular hypertrophy

Efficiency Evaluation of the Combination Therapy for Comorbid Arterial Hypertension with Diabetes Mellitus 2 Type Depending on the Genetic Polymorphism of the Angiotensin-Converting Enzyme

Contact Info

Product

Resources

About