Gene polymorphisms of angiotensin-converting enzyme and angiotensin II Type 1 receptor among chronic kidney disease patients in a Chinese population

Su, Sui-Lung; Lu, Kuo Cheng; Lin, Yuh Feng; Hsu, Yi-Chih; Lee, Pong Ying; Yang, Hsin Yi; Kao, Senyeong

doi:10.1177/1470320311430989

Cited by 27 publications

(20 citation statements)

References 33 publications

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“…The SNP has been investigated to have an association with hypertension in Pakistani and Gulf populations [32,33]. In addition, significant association of A2350G was also observed with chronic kidney disease (CKD) in Taiwanese and SLE in Northern Chinese Han [10,34]. The findings indicated the SNP could be served as the regulator to the blood pressure, and thus leading to the renal complications, such as diabetic nephropathy.…”

Section: Discussionmentioning

confidence: 85%

Association between genetic polymorphisms of ACE & eNOS and diabetic nephropathy

et al. 2014

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Diabetic nephropathy (DN) is the leading cause of end-stage renal disease, with multiple genetic and environmental factors involving in its etiology. ACE and eNOS gene were considered to have important roles in the development and progression of DN. In this study, a case-control study was carried out to investigate the effects of 7 SNPs in ACE gene and 2 SNPs in eNOS gene in the development of DN in Northern China.7 SNPs including A240T, A2350G, A5466C, A2215G, T3892C, C1237T and C3409T of ACE gene and 2 SNPs (G894T and T786C) of eNOS gene were genotyped by polymerase chain reaction restriction fragment length polymorphism method. 431 type 2 diabetic patients with nephropathy (cases) were compared to 420 type 2 diabetic patients without nephropathy (controls) in the study. Data were analyzed by SPSS 17.0 and HaploView software. The frequency distribution of A2350G, 4 haplotyps in ACE gene and G894T in eNOS gene were demonstrated to be different between case and control groups significantly. Whereas other SNPs and haplotypes had no differences in two cohorts. The results revealed that variations of ACE and eNOS gene had association with DN, which indicated ACE and eNOS gene may play an important role in pathogenesis of DN in Northern Chinese Han population.

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Section: Discussionmentioning

confidence: 85%

Association between genetic polymorphisms of ACE & eNOS and diabetic nephropathy

et al. 2014

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“…In a study by Su et al , 6 135 CKD patients and 270 healthy controls among Han Chinese in Taiwan were genotyped for angiotensinogen (AGT-M235T, T174M, A-20C), angiotensin-I-converting enzyme (ACE-A2350G), and angiotensin II type 1 receptor (AGTR1-A1166C, C573T, C-521T) polymorphisms by polymerase chain reaction-restriction fragment length polymorphism analysis. Significant associations were observed in ACE-A2350G and AGTR1-C573T polymorphism in CKD patients ( P =0.01 and P =0.03, respectively).…”

Section: Genetic Componentmentioning

confidence: 99%

Risk factors for chronic kidney disease: an update

Kazancıoğlu

2013

Kidney International Supplements

503

334

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Chronic kidney disease has become a serious public health issue. There are currently over 1.4 million patients receiving renal replacement therapy worldwide. One way to reduce the economic burden of chronic kidney disease would be early intervention. In order to achieve this, we should be able to identify individuals with increased risk of renal disease. An individual's genetic and phenotypic make-up puts him/her at risk for kidney disease. Factors such as race, gender, age, and family history are highly important. For instance, being of African-American decent, older age, low birth weight and family history of kidney disease are considered to be strong risk factors for chronic kidney disease. Moreover, smoking, obesity, hypertension, and diabetes mellitus can also lead to kidney disease. An uncontrolled diabetic and/or hypertensive patient can easily and quickly progress to an end-stage kidney disease patient. Exposure to heavy metals, excessive alcohol consumption, smoking, and the use of analgesic medications also constitute risks. Experiencing acute kidney injury, a history of cardiovascular disease, hyperlipidemia, metabolic syndrome, hepatitis C virus, HIV infection, and malignancy are further risk factors. Determination of serum creatinine levels and urinalysis in patients with chronic kidney disease risk will usually be sufficient for initial screening.

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“…In patients with CKD, risk factors for hypertension include the renin-angiotensin system, endothelin, stimulating peptide, nitric oxide, and vasoactive substances such as renal enzyme factors. Several studies have shown that SNPs in genes related to these factors may influence the development of CKD [19][20][21][22][23] and hypertension in patients with CKD [24,25].…”

Section: Introductionmentioning

confidence: 99%

Association of MYH9 Polymorphisms with Hypertension in Patients with Chronic Kidney Disease in China

Liu¹,

Wang²,

Mi³

et al. 2016

Kidney Blood Press Res

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Background/Aims: This study explored the correlation between hypertension and non-muscle myosin heavy chain 9 (MYH9) gene polymorphisms in Chinese chronic kidney disease (CKD) patients. Methods: This case-control study included 301 patients with CKD and 293 healthy controls. The E1 haplotype single nucleotide polymorphisms (SNPs) rs3752462 and rs4821480 were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. The association between MYH9 polymorphisms and high systolic blood pressure (SBP ≥ 140 mmHg) susceptibility in CKD patients was analysed. Results: The cases and controls had similar genotype and allele distributions at rs3752462 and rs4821480. No GG genotype at rs4821480 was observed. Patients with SBP < 140 mmHg were more likely to have the CC genotype (17.1%) than patients with SBP ≥ 140 mmHg (4.3%) (P = 0.001). Creatinine clearance (OR = 0.99, 95% CI = 0.98-0.10, P = 0.01) was associated with SBP in patients with CKD. The risk of SBP ≥ 140 mmHg was 0.24-fold greater among patients with the CC genotype than among patients with the TT genotype (P = 0.002). Conclusion: The rs3752462 polymorphism of MYH9 is associated with SBP in patients with CKD. The T allele in the dominant model was associated with an elevated risk for high SBP.

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Gene polymorphisms of angiotensin-converting enzyme and angiotensin II Type 1 receptor among chronic kidney disease patients in a Chinese population

Cited by 27 publications

References 33 publications

Association between genetic polymorphisms of ACE & eNOS and diabetic nephropathy

Association between genetic polymorphisms of ACE & eNOS and diabetic nephropathy

Risk factors for chronic kidney disease: an update

Association of MYH9 Polymorphisms with Hypertension in Patients with Chronic Kidney Disease in China

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