Angiotensin-converting enzyme and renin inhibition activities, antioxidant properties, phenolic and flavonoid contents of Cuphea ignea A. DC

Ismail, Walaa M.; Ezzat, Shahira M.; Michel, Haidy E.; Deeb, Kadriya S. El; El-Fishawy, Ahlam M.

doi:10.4103/jrptps.jrptps_81_19

Cited by 8 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The inhibition profiles present in Figure 2, whose blue bars represent the proportion of ACE action and green bars the ACE‐inhibition. These results are according to a study recent with Cuphea species, where the antihypertensive activity of the C. ignea through ACE‐inhibition in vitro was assessed, whose aqueous extract and butanol fraction of the leaves showed the highest ACE‐inhibition with IC 50 values 0.491 and 0.084 mg/mL, respectively [25] …”

Section: Resultssupporting

confidence: 79%

“…and butanol fraction of the leaves showed the highest ACE-inhibition with IC 50 values 0.491 and 0.084 mg/ mL, respectively. [25] Furthermore, in another current study, the ACEinhibition varied between 32.14 to 9.88 %, with mainly inhibition to miquelianin (32.41 %), C. glutinosa (31.66 %), and C. carthagenensis (26.12 %). [2] Therefore, C. urbaniana demonstrated potential similar to the C. carthagenensis species, used largely as antihypertensive in folk medicine.…”

Section: Peak [A]mentioning

confidence: 54%

See 1 more Smart Citation

Polyphenolic Composition and in Vitro Antihypertensive and Anti‐Inflammatory Effects of Cuphea lindmaniana and Cuphea urbaniana

Santos

Soares

Beltrame

et al. 2021

Chemistry & Biodiversity

View full text Add to dashboard Cite

The present study investigates the chemical composition, anti-inflammatory, and antihypertensive activities, in vitro, from extracts of Cuphea lindmaniana and Cuphea urbaniana leaves. The extraction was performed ultrasound-assisted, and UHPLC/MS analysis was in positive mode ionization. The anti-inflammatory activity of the extracts and miquelianin were assayed at concentrations 0.001 -10 μg/mL by chemotaxis on rat polymorphonuclear neutrophils. The antihypertensive activity was performed by angiotensin-converting enzyme (ACE) inhibition. From the nineteen proposed compounds, six of them are described for the first time in this genus. The extracts displayed antichemotactic effect with a reduction of 100 % of the neutrophil migration, in vitro, in most concentrations. The ACE-inhibition presented results ranging from 19.58 to 22.82 %. In conclusion, C. lindmaniana and C. urbaniana extracts contain a rich diversity of flavonoids and display in vitro anti-inflammatory and antihypertensive potential. Thus, this study could serve as a scientific baseline for further investigation, on developmental novel products with therapeutic actions.

show abstract

Section: Resultssupporting

confidence: 79%

Section: Peak [A]mentioning

confidence: 54%

Polyphenolic Composition and in Vitro Antihypertensive and Anti‐Inflammatory Effects of Cuphea lindmaniana and Cuphea urbaniana

Santos

Soares

Beltrame

et al. 2021

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

“…These results clearly support the in vitro antihypertensive activity previously reported by the authors for the ethanolic extract of the leaves. 9 Also, recent studies on other Cuphea species viz., Cuphea glutinosa and C. carthagenesis revealed significant in vitro ACE inhibition for both plant extracts, in addition to high kaempferol, quercetin, and myricetin glycoside content previously reported for their ACE inhibition activities. 50 Restored nitric oxide levels exhibited by the ethanolic extract in both dose levels participated to a large extent in the blood pressure-lowering activity via vasorelaxation effect as reported for C. carthagenesis Jacq McBride on aortic rings.…”

Section: Discussionmentioning

confidence: 99%

In Vivo Antihypertensive Activity and UHPLC-Orbitrap-HRMS Profiling of Cuphea ignea A. DC.

et al. 2022

View full text Add to dashboard Cite

Cuphea ignea A. DC. is an ornamental tropical plant belonging to the family Lythraceae. The aim of this study is to verify the in vivo antihypertensive potential of C. ignea A. DC. and to explore its metabolic profile using a UHPLC-Orbitrap-HRMS technique. The results revealed that the ethanolic extract of the leaves in two doses (250 and 500 mg/kg b.wt.) significantly normalized the elevated systolic blood pressure in N(G)-nitro-l-arginine-methyl ester-induced hypertension in rats. An angiotensin-converting enzyme (ACE) concentration was significantly decreased by the high dose extract compared to lisinopril. Nitric oxide (NO) level was significantly restored by both doses. Concerning the oxidative stress parameters, both doses displayed significant reduction in malondialdehyde (MDA) level while the high dose restored elevated glutathione level. These biochemical results were clearly supported by the histopathological examination of the isolated heart and aorta. A UHPLC-Orbitrap-HRMS study was represented by a detailed metabolic profile of leaves and flowers of C. ignea A. DC., where 53 compounds were identified among which flavonoids, fatty acids, and hydrolysable tannins were the major identified classes. This study established scientific evidence for the use of C. ignea A. DC., a member of genus Cuphea as a complementary treatment in the management of hypertension.

show abstract

“…Recent reports revealed that Cuphea ignea A. DC. possesses significant antiulcerogenic, antitumor, antioxidant and antihypertensive activities [ [13] , [14] , [15] ]. Thirteen compounds were identified in Cuphea ignea A. DC.…”

Section: Introductionmentioning

confidence: 99%

“…ethanolic extract including flavonoids, phenolic acids, hydrolysable tannin and coumarin compound [ 13 ]. Different extracts of the plant possess high content of polyphenols comprising phenolic acids and flavonoids especially the ethanolic extract of the leaves [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Delineating a potent antiviral activity of Cuphea ignea extract loaded nano-formulation against SARS-CoV-2: In silico and in vitro studies

Mahmoud

Ismail

Moatasim

et al. 2021

Journal of Drug Delivery Science and Technology

View full text Add to dashboard Cite

The outbreak of coronavirus disease-2019, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a worldwide emerging crisis. Polyphenols are a class of herbal metabolites with a broad-spectrum antiviral activity. However, most polyphenols encounter limited efficacy due to their poor solubility and degradation in neutral and basic environments. Thus, the effectiveness of their pharmaceutical application is critically dependent on the delivery systems to overcome the aforementioned drawbacks. Herein, Polyphenols-rich Cuphea ignea extract was prepared and its constituents were identified and quantified. Molecular docking was conducted for 15 compounds in the extract against SARS-CoV-2 main protease, among which rutin, myricetin-3- O -rhamnoside and rosmarinic acid depicted the most promising antiviral activity. Further, a self-nanoemulsifying formulation, composed of 10% oleic acid, 40% tween 20 and propylene glycol 50%, were prepared to improve the solubility of the extract components and enable its concurrent delivery permitting combined potency. Upon dilution with aqueous phases, the formulation rapidly form nanoemulsion of good stability and excellent dissolution profile in acidic pH when compared to the crude extract. It inhibited SARS-CoV-2 completely in vitro at a concentration as low as 5.87 μg/mL presenting a promising antiviral remedy for SARS-CoV-2, which may be attributed to the possible synergism between the extract components.

show abstract

Angiotensin-converting enzyme and renin inhibition activities, antioxidant properties, phenolic and flavonoid contents of Cuphea ignea A. DC

Cited by 8 publications

References 0 publications

Polyphenolic Composition and in Vitro Antihypertensive and Anti‐Inflammatory Effects of Cuphea lindmaniana and Cuphea urbaniana

Polyphenolic Composition and in Vitro Antihypertensive and Anti‐Inflammatory Effects of Cuphea lindmaniana and Cuphea urbaniana

In Vivo Antihypertensive Activity and UHPLC-Orbitrap-HRMS Profiling of Cuphea ignea A. DC.

Delineating a potent antiviral activity of Cuphea ignea extract loaded nano-formulation against SARS-CoV-2: In silico and in vitro studies

Contact Info

Product

Resources

About