Angiotensin-Converting Enzyme (ACE) D Allele as a Risk Factor for Increase Serum Interleukin-6 and Interleukin-8 in Psoriasis Patients

Elneam, Ahmed Ibrahim Abd; Al‐Dhubaibi, Mohammed Saleh; Alrheam, Ali Ismaiel Ali Abd

doi:10.3889/oamjms.2018.188

Cited by 16 publications

(27 citation statements)

References 28 publications

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“…This suggests that the DD genotype and the D allele of the ACE I/D gene are associated with increased susceptibility for acne development and was as the same as the condition in various inflammatory disorders where this polymorphism was investigated, including Behcet's disease, vitiligo, and psoriasis …”

Section: Discussionmentioning

confidence: 99%

“…The association between ACE gene I/D polymorphism and different skin disorders had been previously investigated but it was not investigated in AV. So, we tried to reveal the hypothesized link between ACE gene I/D polymorphism, and AV risk among a sample of patients.…”

Section: Introductionmentioning

confidence: 99%

“…nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase) which augments reactive oxygen species (ROS) production, resulting in an oxidative stress state. 8 The association between ACE gene I/D polymorphism and different skin disorders had been previously investigated [9][10][11][12] but it was not investigated in AV. So, we tried to reveal the hypothesized link between ACE gene I/D polymorphism, and AV risk among a sample of patients.…”

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confidence: 99%

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Angiotensin‐converting enzyme gene insertion/deletion polymorphism and family history in severe acne vulgaris

Sorour

Mustafa

Alhusseni

et al. 2019

J of Cosmetic Dermatology

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Summary Background Acne vulgaris is an inflammatory disorder with a profound heterogenous aetio‐pathophysiology. ACE gene I/D polymorphism affects angiotensin‐converting enzyme activities that play a role in inflammation. However, there are no molecular genetic studies investigating the contribution of ACE gene insertion/deletion polymorphism in the genetic background of acne vulgaris. Aims The aim of this work was to reveal the relation between the ACE gene I/D polymorphism and acne vulgaris development among a sample of patients. Patients and Methods This study included 100 acne vulgaris patients in addition to 120 matched control subjects. The ACE gene I/D polymorphism was analyzed using polymerase chain reaction (PCR). Results The distribution of DD, ID genotypes, and D allele showed higher frequency in AV patients than in controls (P < 0.001 for all). Moreover, positive family history and ACEI/D gene polymorphism (DD + ID genotypes) were considered as independent predictors for severe acne grades (P ≤ 0.001 and 0.046, respectively) in multivariate analysis. Conclusions The current study results suggest that the D allele of the ACE I/D gene polymorphism might confer risk to AV among the studied patients. Moreover, ACE I/D gene polymorphism and positive family history were considered as independent predictors of severe AV.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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Angiotensin‐converting enzyme gene insertion/deletion polymorphism and family history in severe acne vulgaris

Sorour

Mustafa

Alhusseni

et al. 2019

J of Cosmetic Dermatology

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“…Twelve studies reported their research in Caucasian ethnicity [21-23, 25-30, 32-34] and four studies [9,20,24,31] in Asian ethnicity. Among Caucasian ethnicity, four studies [23,26,27,33] were conducted in Arab population, four studies [21,25,28,29] enrolled European population, while the remaining four studies [22,30,32,34] evaluated other populations (Pakistani, Iranian and Turkish populations).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…With regard to the controls source, nine studies [9, 20, 23-27, 31, 34] enrolled hospital-based patients, two studies [29,30] were population-based, and five studies [21,22,28,32,33] enrolled controls of unknown origin. In most of the considered studies, the ratio of patients affected by different psoriasis subtypes was not reported [9,20,21,24,31,32,34], while only 5 and 4 studies were conducted in groups of patients affected predominantly by psoriasis vulgaris [22,25,26,28,33] and psoriatic arthritis [23,27,29,30], respectively. In all studies the used genotyping method was polymerase chain reaction (PCR).…”

Section: Study Characteristicsmentioning

confidence: 99%

Angiotensin-converting enzyme gene insertion/deletion polymorphism and susceptibility to psoriasis: a systematic review and meta-analysis

2020

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Background: Psoriasis is a multifactorial disorder, impacted by both genetic and environmental factors. Herein, a meta-analysis assessed the association of angiotensin-converting enzyme gene insertion/deletion (ACE I/D) polymorphism and psoriasis susceptibility. Methods: A systematic search was used in databases of PubMed/Medline, Scopus, Web of Science, and Cochrane Library up to January 2019 without language restriction. A dichotomous analysis was carried out by RevMan 5.3 using crude odds ratio (OR) and 95% confidence interval (CI) to investigate the association between ACE I/D polymorphisms and the risk of psoriasis. A funnel plot analysis was used by CMA 2.0 to estimate a significant existence of publication bias. Results: Out of 61 studies retrieved from the databases, 16 studies were included in the meta-analysis. The pooled ORs for models of D vs. I, DD vs. II, ID vs. II, ID + DD vs. II, and DD vs. II + ID genotypes were 0.

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LncRNA UCA1 negatively regulates NF‐kB activity in psoriatic keratinocytes through the miR125a‐A20 axis

Wen

Cong

et al. 2021

The Kaohsiung J of Med Scie

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Psoriasis is one of the most common chronic inflammatory skin diseases that affects approximately 3% of the world's population. Hyper proliferation, infiltration of inflammatory cells and aberrant differentiation of keratinocytes are the three most important characteristics of psoriasis. Previous reports showed that NF‐κBis the crucial mediator linking psoriatic keratinocytes and immune cell states through its effects on chemokine and cytokine production. To identify the role of NF‐κB in psoriasis, we conducted ELISA assay to detect the activity of NF‐κB in lesional skin and nonlesional skin of patients with psoriasis. Mounting evidence suggests that the interaction between long noncoding RNAs (lncRNAs) and microRNAs plays important role in the regulation of the initiation and development of various diseases. In this article, we identified that lncRNA UCA1 was down‐regulated in lesional skin of patients with psoriasis. Further studies showed that lncRNA UCA1 could promote the expression of A20 by inhibitingmiR125a, and up‐regulated A20 decreased the activity of NF‐κB through its ubiquitin editing function. Taken together, we identified and demonstrated that lncRNA UCA1 negatively regulated NF‐κB activity in psoriasis through the miR125a‐A20 axis.

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Angiotensin-Converting Enzyme (ACE) D Allele as a Risk Factor for Increase Serum Interleukin-6 and Interleukin-8 in Psoriasis Patients

Cited by 16 publications

References 28 publications

Angiotensin‐converting enzyme gene insertion/deletion polymorphism and family history in severe acne vulgaris

Angiotensin‐converting enzyme gene insertion/deletion polymorphism and family history in severe acne vulgaris

Angiotensin-converting enzyme gene insertion/deletion polymorphism and susceptibility to psoriasis: a systematic review and meta-analysis

LncRNA UCA1 negatively regulates NF‐kB activity in psoriatic keratinocytes through the miR125a‐A20 axis

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