Angiotensin-converting enzyme gene insertion/deletion polymorphism and susceptibility to psoriasis: a systematic review and meta-analysis

Ramezani, Mazaher; Zavattaro, Elisa; Sadeghi, Masoud

doi:10.1186/s12881-019-0943-3

Cited by 13 publications

(6 citation statements)

References 39 publications

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“…In comparison with control group, the psoriatic patients show higher serum levels of ACE that associates with lipid profile modulation, reflecting an increased stress oxidative status as an underlying risk factor in cardiovascular disorders 72 . Despite disease severity and family history, the results of a meta-analysis also revealed that ID and DD genotypes may serve a protective role against psoriatic arthritis, particularly in Caucasian patients 73 .…”

Section: Angiotensin-converting Enzyme (Ace) Inhibitorsmentioning

confidence: 99%

Causes of Autoimmune Psoriasis and Associated Cardiovascular Disease: Roles of Human Endogenous Retroviruses and Antihypertensive Drugs—A Systematic Review and Meta-analysis

Rezabakhsh,

Manjili,

Hosseinifard

et al. 2023

Preprint

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Current treatments are ineffective to cure or prevent occurrences of autoimmune psoriasis and psoriatic cardiovascular disease/CVD. Psoriasis is associated with deregulated expressions of human endogenous retroviruses (ERVs) variants. ERV transcripts and proteins are detected in lesioned biopsies—without assembled viral particles—in addition to antibody and T-cell responses against ERV-K dUTPase. In persons living with HIV-1, manifestations of psoriasis are exacerbated variably. These may depend on multiple factors, differences in ERVs expressions, subtypes of HIV-1, and/or epigenetics. This article represents a quantitative risk assessment and meta-analysis approach with an attempt to assess causality. We surmise that mutated ERVs trigger aberrant proliferation and differentiation of keratinocytes, which in turn induce proinflammatory polarization. Independent risk factors and/or covariates with a range of relative risk/RR ratios appear to significantly impact the development of autoimmune psoriasis or immune intolerance, plausibly through ERVs genes activity. Given the antihypertensive drug’s potential in psoriasis development, a probable role in promising either ERVs activation or perturbations in epigenetic factors is questionable. Although the correlational nature of the data based on RR ratios prevents making robust conclusions, we reckon that the likelihood of attributable risk factors for certain antihypertensive drugs may stem from their pleiotropic effects or potentials for inducing ERV-mediated dysregulation of keratinocytes and/or endothelial cells. These findings expand our knowledge regarding ERV activations and HIV-1, antihypertensive drugs use, and incidents of psoriatic disease, and call for exploring cell-specific therapies aimed at blocking or reversing mutated ERVs gene activity toward attaining stable remissions in psoriasis and associated CVD.

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Section: Angiotensin-converting Enzyme (Ace) Inhibitorsmentioning

confidence: 99%

Causes of Autoimmune Psoriasis and Associated Cardiovascular Disease: Roles of Human Endogenous Retroviruses and Antihypertensive Drugs—A Systematic Review and Meta-analysis

Rezabakhsh,

Manjili,

Hosseinifard

et al. 2023

Preprint

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“…Interestingly, the angiotensin-converting enzyme (ACE) gene, which is also a key component in the renin–angiotensin system, was widely reported to be associated with psoriasis [ 89 , 90 , 91 , 92 , 93 , 94 ], further supporting the involvement of the renin–angiotensin system in the development of psoriasis and its related hypertension. In particular, different polymorphisms in the angiotensinogen gene ( AGT ) have been reported to influence the rate of AGT transcription [ 95 ], and the D allele is associated with higher concentrations of ACE mRNA in cells and increased ACE concentration and activity in plasma and serum [ 91 ].…”

Section: Higher Prevalence Of Traditional CV Risk Factors In Psoriasi...mentioning

confidence: 99%

Psoriasis and Cardiometabolic Diseases: Shared Genetic and Molecular Pathways

Piaserico

Orlando

Messina

2022

IJMS

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A convincing deal of evidence supports the fact that severe psoriasis is associated with cardiovascular diseases. However, the precise underlying mechanisms linking psoriasis and cardiovascular diseases are not well defined. Psoriasis shares common pathophysiologic mechanisms with atherosclerosis and cardiovascular (CV) risk factors. In particular, polymorphism in the IL-23R and IL-23 genes, as well as other genes involved in lipid and fatty-acid metabolism, renin–angiotensin system and endothelial function, have been described in patients with psoriasis and with cardiovascular risk factors. Moreover, systemic inflammation in patients with psoriasis, including elevated serum proinflammatory cytokines (e.g., TNF-α, IL-17, and IL-23) may contribute to an increased risk of atherosclerosis, hypertension, alteration of serum lipid composition, and insulin resistance. The nonlinear and intricate interplay among various factors, impacting the molecular pathways in different cell types, probably contributes to the development of psoriasis and cardiovascular disease (CVD). Future research should, therefore, aim to fully unravel shared and differential molecular pathways underpinning the association between psoriasis and CVD.

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“… 84 The results of the another meta-analysis showed that angiotensin-converting enzyme I/D polymorphism may be associated with psoriasis susceptibility, while ID genotype seemed to have a protective role in Caucasian patients affected by psoriatic arthritis. 85 The rs2442598 polymorphism of angiopoietin-2 was significantly associated with psoriasis. 86 The polymorphisms of vitamin D receptor has been found the conflicting results in psoriasis.…”

Section: Toll-like Receptorsmentioning

confidence: 99%

Psoriasis: An Immunogenetic Perspective

Kocaaga

2022

Glob Med Genet

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Psoriasis is an erythematous-squamous dermatosis with a polygenic inheritance history. Both environmental and genetic factors play a role in the etiology of the disease. Over the past two decades, numerous linkage analyzes and genome-wide association studies have been conducted to investigate the role of genetic variation in disease pathogenesis and progression. To date, >70 psoriasis susceptibility loci have been identified, including HLA-Cw6, IL12B, IL23R, and LCE3B/3C. Some genetic markers are used in clinical diagnosis, prognosis, treatment, and personalized new drug development that can further explain the pathogenesis of psoriasis. This review summarizes the immunological mechanisms involved in the etiopathogenesis of psoriasis and recent advances in susceptibility genes and highlights new potential targets for therapeutic intervention.

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Angiotensin-converting enzyme gene insertion/deletion polymorphism and susceptibility to psoriasis: a systematic review and meta-analysis

Cited by 13 publications

References 39 publications

Causes of Autoimmune Psoriasis and Associated Cardiovascular Disease: Roles of Human Endogenous Retroviruses and Antihypertensive Drugs—A Systematic Review and Meta-analysis

Causes of Autoimmune Psoriasis and Associated Cardiovascular Disease: Roles of Human Endogenous Retroviruses and Antihypertensive Drugs—A Systematic Review and Meta-analysis

Psoriasis and Cardiometabolic Diseases: Shared Genetic and Molecular Pathways

Psoriasis: An Immunogenetic Perspective

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