Angiotensin-(1-7), Angiotensin-Converting Enzyme 2 and Mas Receptor in Rat Polycystic Ovaries

Pereira, Virginia M.; Reis, Fernando M.; Casalechi, Maíra; Reis, Adelina Martha dos

doi:10.2174/0929866527666200826104410

Cited by 7 publications

(4 citation statements)

References 38 publications

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“…The ACE2 transcript expression was downregulated in both CGCs and MGCs from women with PCOS. This observation corroborated with our microarray gene expression analysis, reported plasma levels of ACE2 in PCOS women and expression level in oocytes of rat model of PCOS [ 30 , 37 , 38 ]. BSG is known to be regulated by estrogen and progesterone and is important for fertilization and implantation [ 25 ].…”

Section: Discussionsupporting

confidence: 90%

Ovarian granulosa cells from women with PCOS express low levels of SARS-CoV-2 receptors and co-factors

Naigaonkar

Patil

Joseph

et al. 2022

Arch Gynecol Obstet

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Section: Discussionsupporting

confidence: 90%

Ovarian granulosa cells from women with PCOS express low levels of SARS-CoV-2 receptors and co-factors

Naigaonkar

Patil

Joseph

et al. 2022

Arch Gynecol Obstet

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“…The ACE2 expression was downregulated in both CGCs and MGCs from women with PCOS in our study. This observation of lower ACE2 corroborates with our microarray gene expression analysis of granulosa cells, plasma levels reported in PCOS women and studies on oocytes from rat model of PCOS [35,42,43]. Localization and expression of BSG receptor has been a point of interest considering that BSG is known to be regulated by estrogen and progesterone and is important for fertilization and implantation [30].…”

Section: Discussionsupporting

confidence: 88%

Ovarian Granulosa Cells From Women With Pcos Express Low Levels of Sars-Cov-2 Receptors and Co-Factors

Naigaonkar

Patil

Joseph

et al. 2021

Preprint

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Purpose: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is global pandemic with more than 3 million deaths so far. Female reproductive tract organs express coronavirus-associated receptors and factors (SCARFs); suggesting they may be susceptible to SARS-CoV-2 infection however the susceptibility of ovary/follicle/oocyte to the same is still elusive. Co-morbidities like obesity, type-2 diabetes mellitus, cardiovascular disease etc. increase the risk of SARS-CoV-2 infection. These features are common in women with polycystic ovary syndrome (PCOS), warranting further scope to study SCARFs expression in ovary of these women. Materials and methods: SCARFs expression in ovary and ovarian tissues of women with PCOS and healthy women was explored by analyzing publically available microarray datasets. Transcript expression of SCARFs were investigated in mural and cumulus granulosa cells (MGCs and CGCs) from control and PCOS women undergoing in vitro fertilization (IVF). Results: Microarray data revealed that ovary expresses all genes necessary for SARS-CoV-2 infection. PCOS women mostly showed down-regulated/unchanged levels of SCARFs. MGCs and CGCs from PCOS women showed lower expression of receptors ACE2, BSG and DPP4 and protease CTSB than in controls. MGCs showed lower expression of protease CTSL in PCOS than in controls. Expression of TMPRSS2 was not detected in both cell types. Conclusions: Human ovarian follicle may be susceptible to SARS-CoV-2 infection. Lower expression of SCARFs in PCOS indicate that the risk of SARS-CoV-2 infection to the ovary may be lesser in these women than controls. This knowledge may help in safe practices at IVF settings in the current pandemic. Keywords: SARS-CoV-2, COVID-19, Ovarian granulosa cells, Oocyte, PCOS, IVF

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“…Under the circumstances, RAS system expression levels are affected by multiple hormonal changes. As a consequence, the results of this experiment cannot preferably express the changes of RAS components in PCOS (72). In the endometrium of PCOS patients, a study of 15 endometrium of PCOS patients showed that the mRNA expression levels of ACE2, AT1, AT2 and Mas receptors in the endometrium of PCOS patients were higher than those in the control groups (73), These results make it clear that the elevated expression level of RAS components may affect the development of endometrium and play a role in its pathological process.…”

Section: Polycystic Ovary Syndromementioning

confidence: 92%

Physiological and pathological roles of Ang II and Ang- (1-7) in the female reproductive system

et al. 2022

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The local Renin-Angiotensin System (RAS) has been demonstrated to exist in a wide range of tissues and organs, In the female reproductive system, it is mainly found in the ovary, uterus and placenta. The RAS system is made up of a series of active substances and enzymes, in addition to the circulating endocrine renin-angiotensin system. The active peptides Angiotensin II (Ang II) and Angiotensin (1-7) (Ang-(1-7)), in particular, appear to have distinct activities in the local RAS system, which also controls blood pressure and electrolytes. Therefore, in addition to these features, angiotensin and its receptors in the reproductive system seemingly get involved in reproductive processes, such as follicle growth and development, as well as physiological functions of the placenta and uterus. In addition, changes in local RAS components may induce reproductive diseases as well as pathological states such as cancer. In most tissues, Ang II and Ang- (1-7) seem to maintain antagonistic effects, but this conclusion is not always true in the reproductive system, where they play similar functions in some physiological and pathological roles. This review investigated how Ang II, Ang- (1-7) and their receptors were expressed, localized, and active in the female reproductive system. This review also summarized their effects on follicle development, uterine and placental physiological functions. The changes of local RAS components in a series of reproductive system diseases including infertility related diseases and cancer and their influence on the occurrence and development of diseases were elucidated. This article reviews the physiological and pathological roles of Ang II and Ang- (1-7) in female reproductive system,a very intricate system of tissue factors that operate as agonists and antagonists was found. Besides, the development of novel therapeutic strategies targeting components of this system may be a research direction in future.

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Angiotensin-(1-7), Angiotensin-Converting Enzyme 2 and Mas Receptor in Rat Polycystic Ovaries

Cited by 7 publications

References 38 publications

Ovarian granulosa cells from women with PCOS express low levels of SARS-CoV-2 receptors and co-factors

Ovarian granulosa cells from women with PCOS express low levels of SARS-CoV-2 receptors and co-factors

Ovarian Granulosa Cells From Women With Pcos Express Low Levels of Sars-Cov-2 Receptors and Co-Factors

Physiological and pathological roles of Ang II and Ang- (1-7) in the female reproductive system

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