Ovarian granulosa cells from women with PCOS express low levels of SARS-CoV-2 receptors and co-factors

Naigaonkar, Aalaap; Patil, Krutika; Joseph, Shaini; Hinduja, Indira; Mukherjee, Srabani

doi:10.1007/s00404-022-06567-4

Cited by 4 publications

(8 citation statements)

References 58 publications

(89 reference statements)

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“…On the other hand, there is evidence regarding presence of this receptor in ovaries, 47 so the effect of COVID‐19 on AMH level, which is reported in this study, could be due to direct involvement of ovaries. This statement is consistent with findings of a study by Naigaonkar et al that reported a lower rate of ovarian involvement among COVID‐19 women with less “coronavirus‐associated receptors and factors” 48 . Transmembrane serine protease 2 (TMPRSS2) is the other entry molecule of SARS‐CoV‐2 and co‐expression of TMPRSS2 and ACE is also observed in ovary cells 49 .…”

Section: Discussionsupporting

confidence: 91%

“…This statement is consistent with findings of a study by Naigaonkar et al that reported a lower rate of ovarian involvement among COVID‐19 women with less “coronavirus‐associated receptors and factors”. 48 Transmembrane serine protease 2 (TMPRSS2) is the other entry molecule of SARS‐CoV‐2 and co‐expression of TMPRSS2 and ACE is also observed in ovary cells. 49 Another possible mechanism could be the effect of hyperinflammatory state caused by COVID‐19.…”

Section: Discussionmentioning

confidence: 99%

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The effect of COVID‐19 and COVID‐19 vaccination on serum anti‐Mullerian hormone: A systematic review and meta‐analysis

Ghaemi,

Hantoushzadeh,

Shafiee

et al. 2024

Immunity Inflam & Disease

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ObjectiveThe current study aims to evaluate the impact of COVID‐19 infection and vaccination on ovarian reserve by detecting the anti‐Mullerian hormone (AMH) level.MethodPubMed, Embase, Web of Science, and Scopus has been searched for studies assessing the effect of COVID‐19 infection and/or vaccination on AMH levels up to February 27, 2023. Based on PRISMA 2020 statement criteria, a systematic review and meta‐analysis of included studies were performed. The studies' quality was assessed by the National Institute of Health (NIH) quality assessment tool. The standardized mean difference (MD) of the AMH level was used and the quantitative values of each study were pooled separately by using a random effect model.ResultsOut of 246 studies screened, 18 were included in the systematic review and 14 in the meta‐analysis. Included studies were published between 2021 and 2022 and were conducted in different countries, including the USA (n = 3), China (n = 2), Russia (n = 2), Turkey (n = 5), Israel (n = 3), Czech (n = 2), and Spain (n = 1). Eight studies investigated the effect of SARS‐CoV‐2 infection on AMH levels, and ten studies investigated the possible effect of COVID‐19 vaccination on AMH levels. The pooled analysis showed a statistically significant decrease in AMH levels after COVID‐19 infection (SMD: −0.24; 95% CI: −0.36 to −0.11; I2 = 0%; p = .0003). Vaccination analysis showed a nonstatistically significant change in AMH levels after COVID‐19 vaccination (SMD: −0.11; 95% CI: −0.25 to 0.04; I2 = 35%; p = .14).ConclusionCOVID‐19 infection can result in ovarian reserve injury by reducing the AMH level but getting vaccinated against COVID‐19 has no impact on the AMH level.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

The effect of COVID‐19 and COVID‐19 vaccination on serum anti‐Mullerian hormone: A systematic review and meta‐analysis

Ghaemi,

Hantoushzadeh,

Shafiee

et al. 2024

Immunity Inflam & Disease

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“…have demonstrated that lower expression of “coronavirus-associated receptors and factors” in women with polycystic ovarian syndrome (PCOS) which indicates that the risk of SARS-CoV-2 infection to the ovary may be lesser in these women. [ 13 ] This study delineates that susceptibility to the SARS-CoV-2 virus might be different among women with already established different intrinsic disease processes. Similarly, Colaco et al .…”

Section: Discussionmentioning

confidence: 99%

Does coronavirus disease-19 infection affect ovarian reserve in infertile women? A retrospective study

et al. 2022

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“…Then, 29 potential full texts were assessed, and 11 studies were included in this review. [18][19][20][21][22][23][24][25][26][27][28] The flow of studies is illustrated in Figure 1.…”

Section: Study Selectionmentioning

confidence: 99%

“…[21][22][23][24] A retrospective cohort study discussed both biomarkers and COVID-19 susceptibility. 25 A cross sectional study discussed the expression of the SARS-Co-V-2 receptors on the ovarian granulosa cells. 26 In total, four papers, two cohorts 20,28 and two cross sectionals, 18,19 discussed the psychological aspect such as depression and anxiety.…”

Section: Characteristics Of the Included Studies And Synthesis Of The...mentioning

confidence: 99%

COVID-19 and the need for special care for women with polycystic ovary syndrome: A systematic review

Alrubasy,

Sameer,

Taha

et al. 2024

F1000Res

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Objective The study investigates the association between coronavirus disease 2019 (COVID-19) and polycystic ovary syndrome (PCOS) and assess whether women with PCOS are at a higher susceptibility and risk for COVID-19 complications. Methods This review analyzes articles indexed in PubMed, Scopus, Google Scholar, and the Cochrane Library, focusing on the onset of the COVID-19 pandemic in December 1, 2019, until November 1, 2022. The quality of the evidence was assessed using the NIH quality assessment tool. The study was registered on PROSPERO (CRD42023371956) on January 12, 2023. Results A total of 11 observational studies were identified, totaling 22,155 PCOS patients. Despite the heterogeneity of the included studies, the findings of most of the studies were similar in terms of increased susceptibility and severity of COVID-19 infection in PCOS patients. PCOS patients were reported to have a 51% higher risk of COVID-19 infection than non-PCOS women (HR =1.51). Many causes have been identified to play a role, most notably the overactivation of the renin-angiotensin system (RAS) and elevated levels of RAS-associated proteins, decreased serum levels of neuropilin-1 (sNRP1), elevated serum biomarkers such as platelet degranulation and coagulation cascade markers increased acute phase response, and lower levels of vitamin D could render PCOS patients susceptible to a chronic inflammatory state, which can also lead to difficulties and severe consequences, when impacted by COVID-19. Furthermore, the COVID-19 pandemic also influenced psychological well-being, with an increase in the incidence and severity of depression and anxiety among PCOS patients in the COVID-19 pandemic era compared to healthy individuals. Conclusions Patients with PCOS are more likely to get infected with COVID-19 and display a higher affinity to severe infections and complications due to overlapping and confounding factors. These findings suggest that PCOS patients may need more medical attention when infected with COVID-19.

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Ovarian granulosa cells from women with PCOS express low levels of SARS-CoV-2 receptors and co-factors

Cited by 4 publications

References 58 publications

The effect of COVID‐19 and COVID‐19 vaccination on serum anti‐Mullerian hormone: A systematic review and meta‐analysis

The effect of COVID‐19 and COVID‐19 vaccination on serum anti‐Mullerian hormone: A systematic review and meta‐analysis

Does coronavirus disease-19 infection affect ovarian reserve in infertile women? A retrospective study

COVID-19 and the need for special care for women with polycystic ovary syndrome: A systematic review

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