Angiosuppressive properties of marine-derived compounds—a mini review

Yue, Patrick Ying-Kit; Leung, Howard; Li, Adela J.; Chan, Tracy N.C.; Lum, Judy Tsz-Shan; Chung, Yan-Tung; Sung, Yik Hei; Wong, Ming Hung; Leung, Kwong Sak; Zeng, Eddy Y.

doi:10.1007/s11356-015-5536-x

Cited by 4 publications

(2 citation statements)

References 72 publications

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“…Thus, the inhibition of this process could suppress tumor progression. Previous studies have shown that many marine-derived substances can display inhibitory effects on new vessel development (66). This work showed that Fx failed to prevent HUVEC migration in the presence of GBM1 cells.…”

Section: Conditioned Medium Of Fucoxanthin Treated-gbm Cells Inhibite...mentioning

confidence: 66%

Anti-cancer Effects of Fucoxanthin on Human Glioblastoma Cell Line

et al. 2020

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Background/Aim: Glioblastomas (GBMs) are the most malignant primary brain tumor. New treatment strategies against the disease are urgently needed, as therapies are not completely efficient. In this study, we evaluated the antitumorigenic activity of the carotenoid fucoxanthin (Fx) on human GBM cells in vitro. Materials and Methods: GBM1 cell viability and proliferation was assessed by MTT reduction, Ki67 and single cell cloning assays. GBM1 migration and invasion were analyzed by wound healing and Transwell assays. Apoptosis and necrosis were analyzed by flow cytometry, and the mitochondrial membrane potential (ΔΨm) by the selective fluorescent dye tetramethylrhodamine ethyl ester. Cell morphology was analyzed through scanning electron microscopy and transmission electron microscopy. Fx anti-angiogenic effect was assessed by the CAM ex ovo assay. Results: Fx decreased cell viability in a concentration-dependent manner (40-100 μ M) in GBM1, A172 and C6 cell lines and was not cytotoxic to murine astrocytes. In addition, Fx inhibited the proliferation and clonogenic potential, and decreased migration and invasion of GBM1 cells. Furthermore, Fx induced apoptosis, loss of ΔΨm and ultrastructural alterations in GBM1. Fx-treated GBM1 cells-conditioned medium reduced the quail yolk membrane vascularity. Conclusion: Fx induces cytotoxicity, anti-proliferative, antiinvasive and anti-angiogenic effects on GBM1 cells.Gliomas are primary tumors that affect the central nervous system (CNS). The origin of glioma cells is not completely elucidated, and may derive from dedifferentiation of a mature cell type, glial progenitor cells or primitive neural stem cells (1). The primary malignant brain neoplasms global-gender incidence rate is approximately 2.6 per 100,000 for females and 3.7 per 100,000 for males, per year (2). Gliomas compose only 27% of all CNS primary neoplasms, however, it represents almost 80% of all malignant primary tumors that affect this system (3,4).Gliomas are histopathologically categorized by the World Health Organization (WHO) into different subtypes and grades (I to IV), as oligodendroglioma, oligoastrocytoma and astrocytoma. Grade IV is reserved for a subtype of astrocytoma, the glioblastoma (GBM) (5). GBM is the most malignant glioma and the most frequent primary cerebral tumor, with an incidence of 3.2 cases per 100,000 person/year 6799

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Section: Conditioned Medium Of Fucoxanthin Treated-gbm Cells Inhibite...mentioning

confidence: 66%

Anti-cancer Effects of Fucoxanthin on Human Glioblastoma Cell Line

et al. 2020

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“…Marine organism has evolved chemical means in order to defend themselves against the complex environment ( Gammone et al 2016). Such chemical and biological adaptation generates structural diversity of compounds with various biological activities and potential anticancer effect (Yue et al 2017). Up to 2012, more than 22,000 natural products from marine source have been reported (Gerwick and Moore 2012).…”

Section: Discussionmentioning

confidence: 99%

Thiocoraline mediates drug resistance in MCF-7 cells via PI3K/Akt/BCRP signaling pathway

et al. 2019

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Thiocoraline, a depsipeptide bisintercalator with potent antitumor activity, was first isolated from marine actinomycete Micromonospora marina. It possesses an intense toxicity to MCF-7 cells at nanomolar concentrations in a dose-dependent manner evaluated by MTT assay and crystal violet staining. We established a human breast thiocoraline-resistant cancer subline of MCF-7/thiocoraline (MCF-7/T) to investigate the expression variation of breast cancer resistance proteins (BCRP) and its subsequent influence on drug resistance. Colony-forming assay showed that the MCF-7 cells proliferated faster than the MCF-7/T cells in vitro. Western blot analysis demonstrated that thiocoraline increased the phosphorylation of Akt. Additionally, the sensitivity of tumor cells to thiocoraline was reduced with a concurrent rise in phosphorylation level of Akt and of BCRP expression.These studies indicated that thiocoraline probably mediated the drug resistance via PI3K/Akt/BCRP signaling pathway. MK-2206 dihydrochloride, a selective phosphorylation inhibitor of Akt, significantly decreased MCF-7 cell viability under exposure to thiocoraline compared to the control. However, it was not obviously able to decrease MCF-7/T cell viability when cells were exposed to thiocoraline.

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Immunomodulatory and Therapeutic Potential of Marine Flora Products in the Treatment of Cancer

Singh

Krishna

2019

Bioactive Natural Products for the Management of Cancer: From Bench to Bedside

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Angiosuppressive properties of marine-derived compounds—a mini review

Cited by 4 publications

References 72 publications

Anti-cancer Effects of Fucoxanthin on Human Glioblastoma Cell Line

Anti-cancer Effects of Fucoxanthin on Human Glioblastoma Cell Line

Thiocoraline mediates drug resistance in MCF-7 cells via PI3K/Akt/BCRP signaling pathway

Immunomodulatory and Therapeutic Potential of Marine Flora Products in the Treatment of Cancer

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