Angiostrongylus vasorum and other worms in dogs in Uganda

Bwangamoi, O

doi:10.1136/vr.91.11.267

Cited by 32 publications

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“…These results are similar to those of Mishra and Cens (1971), who observed peaks, associated the with infective larvae migration, growing of the adults worms and patency. Eosinophils alterations were reported by Rosen et al (1970), Bwangamoi (1972), Perry et al (1991), however, Prestwood et al (1981 and Cury (1995) did not find any consistent hematological abnormalities in dogs infected experimentally with A. vasorum.…”

Section: Discussionmentioning

confidence: 81%

“…Adult worms form are found in the right ventricle and the pulmonary artery (and its branches) of domestic dogs and wild carnivores. It is enzootic in dogs in the southwest of France (Guilhon and Cens, 1973), in the United Kingdom, Ireland (Dodd, 1973) and Uganda (Bwangamoi, 1972), with sporadic cases in the USA, Canada (Williams and Lindermann, 1995) and Brazil (Lima et al, 1985).…”

Section: Introductionmentioning

confidence: 99%

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Hematological and coagulation profiles in dogs experimentally infected with Angiostrongylus vasorum (Baillet, 1866)

Cury

Lima

Guimarães

et al. 2002

Veterinary Parasitology

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Hematological and coagulation profiles were studied in crossbred dogs experimentally infected with Angiostrongylus vasorum. Two groups of five dogs were experimentally inoculated with 50 and 100 third stage infective larvae (L(3)) of A. vasorum per kilogram of body weight. A third group of five uninfected animals was used as control. One sample of 10 ml of blood was collected from each animal on the 10, 20, 30, and 45 days after inoculation (dai) and at 30-day intervals thereafter for the remainder of the 210-day experimental period. The blood sample was used for the complete hemogram and platelet count, as well as measurements of prothrombin time, partial thromboplastin time and factors V and VIII. Anemia was observed in infected dogs, 6 weeks after the infection. The eosinophils presented peaks in four periods after infection. Thrombocytopenia became accentuated on the 72 dai. Decreased prothrombin time activity and increased partial thromboplastin time were observed at the 6 and 9 weeks after infection and decreased of factors VIII and V activities occurred from 4 to 6 weeks after infection. It may be conclude that infection by A. vasorum in dogs may cause a discrete anemia during the acute phase which is probably regenerative. In addition, important hemostatic alterations due to the infection suggest a chronic intravascular consumption coagulopathy.

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Section: Discussionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Hematological and coagulation profiles in dogs experimentally infected with Angiostrongylus vasorum (Baillet, 1866)

Cury

Lima

Guimarães

et al. 2002

Veterinary Parasitology

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“…This parasite causes angiostrongylosis, a disease that typically manifests itself in respiratory distress, coughing, dyspnoea, exercise intolerance, weight loss, vomiting, diarrhoea and/or neurological signs, coagulopathies or sudden death (Koch and Willesen, 2009;Schnyder et al, 2010). A. vasorum has emerged as an important pathogen of canids in various countries in the western Palaearctic and eastern Nearctic ecozones (Bwangamoi, 1972;Bolt et al, 1992;Lima et al, 1994;Conboy, 2004;Morgan et al, 2008;Taubert et al, 2008;Jefferies et al, 2010;Di Cesare et al, 2011).…”

Section: Introductionmentioning

confidence: 98%

Mitochondrial genome of Angiostrongylus vasorum: Comparison with congeners and implications for studying the population genetics and epidemiology of this parasite

Gasser

Jabbar

Mohandas

et al. 2012

Infection, Genetics and Evolution

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Angiostrongylus vasorum is a strongylid nematode of major clinical relevance in canids, causing angiostrongylosis. In spite of its increasing importance, the genetics, epidemiology and biology of this parasite are not entirely understood. Mitochondrial (mt) DNA provides useful markers for studies of these areas, but genetic data are scant for A. vasorum and its congeners. Here, the mitochondrial genome was amplified by long-range polymerase chain reaction (long-PCR) from a portion of a single male adult of A. vasorum, sequenced using 454 technology and annotated employing a semi-automated bioinformatic pipeline. This circular mitochondrial genome is 13,422 bp and contains 12 protein-encoding, 22 transfer RNA, and two ribosomal RNA genes, consistent with its congeners and other secernentean nematodes. This mt genome represents a rich source of markers for future investigations of the population genetics and epidemiology of A. vasorum. Molecular tools, employing such mt markers, should be useful for explorations into host specificity and for prospecting for cryptic species, and might also underpin the diagnosis of canine angiostrongylosis.

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“…A. vasorum is recognised to be endemic in France, the United Kingdom, Denmark (Bolt et al, 1994), Italy (Poli et al, 1991;Traversa et al, 2008) and Ireland (Dodd, 1973) but sporadic cases have increasingly occurred in many other countries within Europe (Ablad et al, 2003;Papazahariadou et al, 2007;Sreter et al, 2003;Staebler et al, 2005) and outside Europe in Uganda (Bwangamoi, 1972), Brazil (dos Santos Lima et al, 1985), Australia (Collins et al, 1992) and in Canada (Bourque et al, 2002;Conboy, 2004).…”

Section: Introductionmentioning

confidence: 99%

Larvicidal effect of imidacloprid/moxidectin spot-on solution in dogs experimentally inoculated with Angiostrongylus vasorum

Schnyder

Fahrion

Ossent

et al. 2009

Veterinary Parasitology

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Larvicidal effect of imidacloprid/moxidectin spot-on solution in dogs experimentally inoculated with Angiostrongylus vasorum Schnyder, M; Fahrion, A; Ossent, P; Kohler, L; Webster, P; Heine, J; Deplazes, P Schnyder, M; Fahrion, A; Ossent, P; Kohler, L; Webster, P; Heine, J; Deplazes, P (2009). Larvicidal effect of imidacloprid/moxidectin spot-on solution in dogs experimentally inoculated with Angiostrongylus vasorum. Veterinary Parasitology, Larvicidal effect of imidacloprid/moxidectin spot-on solution in dogs experimentally inoculated with Angiostrongylus vasorum Abstract A controlled, randomized, blinded dose confirmation study was conducted to evaluate the larvicidal efficacy and safety of imidacloprid 10 mg/kg/moxidectin 2.5 mg/kg body weight spot-on solution in dogs experimentally inoculated with 200 infective third stage larvae (L3) of Angiostrongylus vasorum. Twenty-four adult dogs were randomly allocated to three study groups of 8 dogs each. Animals in group 1 were treated 4 days post-inoculation (dpi), those in group 2 at 32 dpi, and the dogs in group 3 were left untreated. All dogs were euthanized and necropsied 56-59 dpi. In order to determine the worm burdens in the arterial lung vessels a method of reverse lung perfusion with phosphate buffered solution after inhibition of coagulation with heparin was applied. In the control group, excretion of first stage larvae (L1) of A. vasorum started 47-55 dpi and all dogs excreted L1 at least on one sample day before euthanasia (0.1-32.5 larvae per gram of faeces). A mean of 99 (SD 42.8) adult parasites were recovered in the post-mortem examinations in these eight control dogs. In contrast, no L1 at all were found in the faeces of dogs of groups 1 and 2, nor were any adult parasites detected at necropsy. Respiratory symptoms were observed in dogs of groups 2 and 3. Pathological findings in the lungs correlated with the treatment groups: in the animals of group 1, no or minimal lesions were found, while in all those of group 2 dispersed patterns of pale pink, slightly raised and consolidated foci were present in all lung lobes. In contrast, the lungs of the dogs from group 3 were severely affected: large confluent areas were hardened, raised and discoloured, with frequent haemorrhagic patches. Pneumonia, thrombi and parasites were histologically confirmed. The lung lymph nodes were regularly enlarged. Hence, imidacloprid/moxidectin spot-on effectively eliminated fourth stage larvae (L4) and immature adult A. vasorum in experimentally infected dogs and prevented patent infections. The earlier an infected dog was treated, the less severe were the pathological lesions observed in the lungs. Twenty-four adult dogs were randomly allocated to three study groups of 8 dogs each. Animals in group 1 were treated 4 days post inoculation (dpi), those in group 2 at 32 dpi, and the dogs in group 3 were left untreated. All dogs were euthanized and necropsied 56-59 dpi. In order to determine the worm burdens in the arterial lung vessels a method of reverse lung perfusion with...

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Angiostrongylus vasorum and other worms in dogs in Uganda

Cited by 32 publications

References 0 publications

Hematological and coagulation profiles in dogs experimentally infected with Angiostrongylus vasorum (Baillet, 1866)

Hematological and coagulation profiles in dogs experimentally infected with Angiostrongylus vasorum (Baillet, 1866)

Mitochondrial genome of Angiostrongylus vasorum: Comparison with congeners and implications for studying the population genetics and epidemiology of this parasite

Larvicidal effect of imidacloprid/moxidectin spot-on solution in dogs experimentally inoculated with Angiostrongylus vasorum

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