Angiostatin overexpression is associated with an improvement in chronic kidney injury by an anti-inflammatory mechanism

Mu, Wei; Long, David A.; Ouyang, Xiaosen; Agarwal, Anupam; Cruz, Pedro; Roncal, Carmen; Nakagawa, Takahiko; Yu, Xueqing; Hauswirth, William W.; Johnson, Richard J.

doi:10.1152/ajprenal.90430.2008

Cited by 34 publications

(25 citation statements)

References 54 publications

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“…For example, the full kringles of Plg (K1-5) caused total regression of human MDA-MB231 breast tumor xenografted in mice, which was correlated with a drastic decrease of functional neovascularization into the tumors and inhibition of metastatic dissemination [27]. Pronounced anti inflammatory effects of AS are documented and extensively studied as well [28,29].…”

Section: Fig 2 Results Of Densitometry Analysis Of Plasminogen (A) mentioning

confidence: 99%

Plasminogen and angiostatin levels in female benign breast lesions

Tykhomyrov¹,

Вовчук²,

Grinenko³

2015

Ukr.Biochem.J.

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Section: Fig 2 Results Of Densitometry Analysis Of Plasminogen (A) mentioning

confidence: 99%

Plasminogen and angiostatin levels in female benign breast lesions

Tykhomyrov¹,

Вовчук²,

Grinenko³

2015

Ukr.Biochem.J.

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“…Введение генно-инженерной конструкции, кодирующей последовательность AS K1-4, в почки, но не в сетчатку, предотвращало TGF-b-и ангиотензин ІІ-индуцированное снижение уровня PEDF. В пользу предположения, что защитное действие AS в почках реализуется за счёт его противовоспалительной активности, свидетельствуют также результаты Mu et al [110]. На модели хронической почечной недостаточности недиабетического происхождения ими было показано, что экспрессия гена, кодирующего AS, способствует снижению степени внутритканевого фиброза на фоне ингибирования инфильтрации макрофагов и Т-лимфоцитов.…”

Section: тихомиров и дрunclassified

Role of angiostatins in diabetic complications

2015

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Angiogenesis is a process through which new blood vessels form from pre-existing vessels. Angiogenesis is regulated by a number of factors of peptide nature. Disbalance of angiogenic system appears to be the major causative factor contributing vascular abnormalities in diabetes mellitus, resulting in various complications. Angiostatins, which are kringle-containing fragments of plasminogen/plasmin, are known to be powerful physiological inhibitors of neovascularization. In the present review, current literature data on peculiarities of production of angiostatins and their functioning at diabetes mellitus are summarized and analyzed for the first time. Also, role of angiostatins in the pathogenesis of typical diabetic complications, including retinopathies, nephropathies and cardiovascular diseases, is discussed. Data presented in this review may be useful for elaboration of novel effective approaches for diagnostics and therapy of vascular abnormalities in diabetes mellitus.

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“…25 Therefore, we assessed peritubular capillaries and inflammation in aging rats. PTC volume, as assessed by Tie2 protein expression (Figure 2a) and staining for RECA-1 (Figure 2b), showed no significant change in 10-or 16-month-old rats but showed a statistically significant decrease in 24-month-old rats compared with 4-month-old rats.…”

Section: Capillary Volume and Inflammation In Aging Rat Kidneymentioning

confidence: 99%

Angiostatin production increases in response to decreased nitric oxide in aging rat kidney

Satoh

Kidokoro

Ozeki

et al. 2013

Laboratory Investigation

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The development of interstitial fibrosis occurs with aging. Impaired angiogenesis, associated with progressive loss of the renal microvasculature, is thought to be a cause of age-related nephropathy. However, the mechanism of capillary loss in aging kidney has not been fully elucidated. Angiostatin is a kringle-containing fragment of plasminogen and is a potent inhibitor of angiogenesis in vivo. Whether angiostatin generation is increased in the aging kidney has not been investigated. We examined 4, 10, 16, and 24-month-old Sprague-Dawley rats for angiostatin production and found that angiostatin generation was increased in aged rats. The protein expression and the activity of cathepsin D-the enzyme for angiostatin production-were increased in aged rats. In the aging kidney, nitric oxide (NO) availability is decreased. To investigate the role of NO in angiostatin production, human umbilical vein endothelial cells were treated with L-NG-nitroarginine methyl ester (L-NAME). L-NAME-treated cells showed increased cathepsin D activity and angiostatin production. For in vivo experiments, 16-to 18-month-old rats were treated with L-NAME or molsidomine for 3 months.

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Angiostatin overexpression is associated with an improvement in chronic kidney injury by an anti-inflammatory mechanism

Abstract: RJ. Angiostatin overexpression is associated with an improvement in chronic kidney injury by an anti-inflammatory mechanism.

Cited by 34 publications

References 54 publications

Plasminogen and angiostatin levels in female benign breast lesions

Plasminogen and angiostatin levels in female benign breast lesions

Role of angiostatins in diabetic complications

Angiostatin production increases in response to decreased nitric oxide in aging rat kidney

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