Angiosarcoma-related cerebral metastases: a systematic review of the literature

Intra-Axial Metastatic Angiosarcoma of the Central Nervous System Associated with Anemia, Pulmonary Tuberculosis and Short Survival

“…Congenital cases have also been reported. [1][2][3][10][11][12] Metastatic CNS AGs are associated with intra-axial hemorrhage, and disseminate to cerebral tissues via a hematogenous route, although direct invasion of adjacent tissues can also occur. The heart is reported as the most common primary site for AG tumors metastasizing to the brain ($75% of cases, usually originating in the atrium).…”

“…The heart is reported as the most common primary site for AG tumors metastasizing to the brain ($75% of cases, usually originating in the atrium). [1][2][3][10][11][12] Less commonprimary sites include the skin, the legs, the lungs, the pleura, the kidneys, the soft tissues, the gastrointestinal tract, the bones, and the spleen. Exposure to industrial solvents, radiation, neurofibromatosis, Maffucci syndrome, Klippel-Trenaunay syndrome, and old surgical scars have been suggested as etiological factors.…”

“…Exposure to industrial solvents, radiation, neurofibromatosis, Maffucci syndrome, Klippel-Trenaunay syndrome, and old surgical scars have been suggested as etiological factors. [12][13][14][15][16] The most common findings of CNS AG are related to the mass effect and hemorrhagic episodes, including headache, nausea, vomiting, dizziness, seizures, hemiparesis, hemianopsia, lethargy, aphasia, and increased intracranial pressure. 1,3,10,[12][13][14] The frontal, temporal, and parietal lobes are predominantly compromised ($70% to 80% of the cases).…”

“…[12][13][14][15][16] The most common findings of CNS AG are related to the mass effect and hemorrhagic episodes, including headache, nausea, vomiting, dizziness, seizures, hemiparesis, hemianopsia, lethargy, aphasia, and increased intracranial pressure. 1,3,10,[12][13][14] The frontal, temporal, and parietal lobes are predominantly compromised ($70% to 80% of the cases). 1,3,10,[12][13][14] The CT/MRI scans usually reveal a heterogeneous hemorrhagic lesion with variable signal intensities on T1-and T2-weighted images and adjacent areas of edema.…”

“…1,3,10,[12][13][14] The frontal, temporal, and parietal lobes are predominantly compromised ($70% to 80% of the cases). 1,3,10,[12][13][14] The CT/MRI scans usually reveal a heterogeneous hemorrhagic lesion with variable signal intensities on T1-and T2-weighted images and adjacent areas of edema. Hydrocephalus, cystic dilation, and calcifications may be identified in large tumors by radiological examination.…”