Angiosarcoma of the liver: a marker tumour for the late effects of Thorotrast in Great Britain

Baxter, Peter; Langlands, A.O.; Anthony, P. P.; Macsween, R. N. M.; Scheuer, Peter J.

doi:10.1038/bjc.1980.69

Cited by 27 publications

(4 citation statements)

References 14 publications

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“…A further 20 adult cases had either been reported to EMAS or published,1 5 6 including two deaths in 1963-73 which were missed in the earlier survey and identified through the Thorotrast study. 32 Histological sections were received for 72 (82%) of these recorded cases, and the panel agreed the diagnosis in 32 (44 %). Seven cases were regarded as doubtful, and four others as unclassifiable, the remainder being agreed as not ASL (table 1).…”

Section: Resultsmentioning

confidence: 98%

Angiosarcoma of the liver: annual occurrence and aetiology in Great Britain.

Baxter¹,

Anthony²,

Macsween³

et al. 1980

Occupational and Environmental Medicine

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Section: Resultsmentioning

confidence: 98%

Angiosarcoma of the liver: annual occurrence and aetiology in Great Britain.

Baxter¹,

Anthony²,

Macsween³

et al. 1980

Occupational and Environmental Medicine

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“…Cohort studies of atomic bomb survivors13‐16 and Mayak nuclear facility workers22‐24 have indicated beyond a doubt that radiation increases liver cancer risk, even though hepatitis virus infection was not taken into account. It is also well known that persistent long‐term internal exposure to α particles from Thorotrast, a radioactive contrast agent, can induce hemangiosarcoma, cholangiocarcinoma, and HCC in humans 41‐43. Because a significant radiation effect is observed in a high proportion of HCC cases having a p53 mutation, it has been suggested that p53 is one of the intracellular targets of atomic bomb radiation and thus a cause of the increased HCC incidence among atomic bomb survivors 44.…”

Section: Discussionmentioning

confidence: 99%

Impact of radiation and hepatitis virus infection on risk of hepatocellular carcinoma

et al. 2011

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In cohort studies of atomic bomb survivors and Mayak nuclear facility workers, radiationassociated increases in liver cancer risk were observed, but hepatitis B virus (HBV) and hepatitis C virus (HCV) infections were not taken strictly into account. We identified 359 hepatocellular carcinoma (HCC) cases between 1970 and 2002 in the cohort of atomic bomb survivors and estimated cumulative incidence of HCC by radiation dose. To investigate contributions of radiation exposure and hepatitis virus infection to HCC risk, we conducted a nested case-control study using sera stored before HCC diagnosis in the longitudinal cohort of atomic bomb survivors. The study included 224 HCC cases and 644 controls that were matched to the cases on gender, age, city, and time and method of serum storage, and countermatched on radiation dose. The cumulative incidence of HCC by follow-up time and age increased significantly with radiation dose. The relative risk (RR) of HCC for radiation at 1 Gy was 1.67 (95% confidence interval: 1.22-2.35) with adjustment for alcohol consumption, body mass index (BMI), and smoking habit, whereas the RRs for HBV or HCV infection alone were 63 (20-241) and 83 (36-231) with such adjustment, respectively. Those estimates changed little when radiation and hepatitis virus infection were fit simultaneously. The RR of non-B, non-C HCC at 1 Gy was 1.90 (1.02-3.92) without adjustment for alcohol consumption, BMI, or smoking habit and 2.74 (1.26-7.04) with such adjustment. Conclusion: These results indicate that radiation exposure and HBV and HCV infection are associated independently with increased HCC risk. In particular, radiation exposure was a significant risk factor for non-B, non-C HCC with no apparent confounding by alcohol consumption, BMI, or smoking habit. (HEPATOLOGY 2011;53:1237-1245 H epatocellular carcinoma (HCC) is one of the most common cancers worldwide, and chronic infections with hepatitis B virus (HBV) or hepatitis C virus (HCV) are recognized as critically important risk factors for HCC. Our previous study actually showed that about 63% of HCC in atomic bomb survivors is related to HCV infection, 14% to HBV infection, and 2% to both HBV and HCV infections. 1 However, an increase of non-B, non-C HCC without HBV and HCV infection has been noted recently in Japan. 2,3 The etiology of non-B, non-C HCC has been poorly understood, although alcoholic hepatitis, nonalcoholic fatty liver disease (NAFLD) including nonalcoholic steatohepatitis (NASH), and hemochromatosis 4,5 are known as risk factors. In Japan, NAFLD has increased along with Westernization of lifestyle, and most NASH cases have developed due to such lifestyle-related diseases such as obesity, diabetes mellitus, and hyperlipidemia. 6 Obesity and diabetes mellitus, as well as NAFLD, have also recently received increased attention as risk factors for HCC. 1,[7][8][9][10][11][12]

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“…En lo que se refiere a la etiología, se ha relacionado el angiosarcoma hepático con la exposición a cloruro de vinilo, pesticidas derivados del arsénico y dióxido de torio (Thorotrast) (5,6). También se han descrito casos de angiosarcomas óseos y de tejidos blandos tras radiaciones (5) y casos postmastectomía radical (con aparición del tumor en la extremidad superior con linfedema)(1).…”

Section: Discussionunclassified

Angiosarcoma pulmonar metastásico

Clemente¹,

Budiño²,

Stein

et al. 2004

An. Med. Interna (Madrid)

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INTRODUCCIÓNEl angiosarcoma es un tumor vascular maligno poco frecuente (1 al 2 % del total de sarcomas). La afectación pulmonar por este tumor no es habitual y suele ser debida a metásta-sis de un tumor primario de otro origen. El diagnóstico de angiosarcoma pulmonar primario es extremadamente raro (1). Dado que la mayor parte de las publicaciones son casos clíni-cos aislados, las manifestaciones y el curso clínico no son bien conocidos. Presentamos un caso de angiosarcoma pulmonar metastásico por su interés y rareza. CASO APORTADOPaciente de 58 años que acudió al servicio de urgencias por hemoptisis de 5 días de evolución. Se trataba de una mujer, no fumadora, con diabetes tipo II controlada con dieta. Padecía desde hacía varios años un síndrome depresivo en tratamiento actualmente con venlafaxina 75 mg al día y alprazolam 0,5 mgr cada 24 horas. Hacía 4 y 2 años había presentado sendos episodios de trombosis venosa profunda. Acudió a urgencias en esta ocasión por notar en los últimos 5 días disnea y expectoración hemoptoica de sangre roja acompañada de coágulos, dolor torácico en hemitórax izquierdo no claramente definido y sensación distérmica. No sín-drome general acompañante. En el examen físico no había datos destacables salvo febrícula de 37,8 ºC y discreta taquicardia sinusal (104 /minuto). En los exámenes complementarios el hemograma, el estudio de coagulación, la bioquímica hepática y el sistemático y sedimento de orina fueron normales. En la bioquímica general solo llamaba la atención una glucemia de 121 mg/dl. La gasometría arterial al ingreso mostraba PaO 2 de 69 mm de Hg, PaCO 2 de 45 mm de Hg, pH de 7,39 y bicarbonato de 25,6 mmol/l. En la radiografía de tórax, se observaron imágenes nodulares bilaterales difusas de diferentes tamaños y en la tomografía axial computerizada 37 [0212-7199 (2004) RESUMENLa afectación pulmonar por angiosarcoma, habitualmente en forma de enfermedad metastásica, es una rara enfermedad. El angiosarcoma pulmonar primario es un tumor extremadamente raro. El pulmón es uno de los lugares más frecuentes de afectación metastásica junto con el híga-do y los ganglios linfáticos. La hemoptisis es el síntomas más frecuente, pudiendo presentarse incluso en forma de hemorragia pulmonar difusa. La radiografía de tórax puede ser normal, pero lo más frecuente es la presencia de múltiples imágenes nodulares. No es habitual que se establezca un diagnóstico precoz por el bajo índice de sospecha derivado de la rareza del tumor. El tratamiento sigue siendo desalentador sobre todo en los angiosarcomas metastásicos cuya supervivencia media es de 9 meses tras el diagnóstico.

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Angiosarcoma of the liver: a marker tumour for the late effects of Thorotrast in Great Britain

Cited by 27 publications

References 14 publications

Angiosarcoma of the liver: annual occurrence and aetiology in Great Britain.

Angiosarcoma of the liver: annual occurrence and aetiology in Great Britain.

Impact of radiation and hepatitis virus infection on risk of hepatocellular carcinoma

Angiosarcoma pulmonar metastásico

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