Angiosarcoma of the Bladder: A Case Report with Regard to Histologic and Immunohistochemical Findings

Primary angiosarcoma of the bladder in a young female

“…In two cases,15 18 the tumours were ‘typical’ in morphology, with hyperchromatic, ‘hobnail’ endothelial cells 17 21. In one case, both typical and ‘spindled’ (fusiform or tapered edges) cells were seen 6. In the remaining three cases, epithelioid cell morphology (prominent nucleoli, abundant eosinophilic cytoplasm) was seen.…”

“…Histologically, four of the six cases6 8 15 18 resembled a ‘classical’ architecture17 21 with anastomosing blood-filled channels lined by malignant cells. One of the cases resembled a ‘solid’ architecture,2 with malignant cells forming sheets or nests in the absence of evidence of lumen formation.…”

“…All cases are summarised in Tables 1–3. Of these 16 cases, six cases involved prior exposure to abdominopelvic radiotherapy,10–13 17 20 one case initially presented with a cutaneous manifestation of angiosarcoma,19 one case appeared to be a variant of Kaposi’s sarcoma16 and two cases arose from haemangiomas,7 9 leaving five previous cases to be true primary bladder angiosarcomas with the current case being the sixth 2 6 8 14 15 18. With the inclusion of the current case, the mean age at diagnosis of true primary bladder angiosarcoma (excluding those mentioned above) is 54.5 (range 32–78).…”

“…A literature search using PubMed revealed 15 cases of angiosarcoma affecting the bladder, with the present case being the sixteenth 2 6–20. All cases are summarised in Tables 1–3.…”

Primary angiosarcoma of the bladder: cytomorphology and differential diagnosis

“…Another case of anaplastic angiosarcoma resembling Kaposi's sarcoma was diagnosed in the bladder and skin of a homosexual male 3 . Only two cases of de novo angiosarcoma of the bladder exist in the literature 4 , 5 . All of these previous reports have been based on surgical biopsy and histologic material.…”