Angiomorphology of the Human Larynx and Renal Carcinoma a Comparative Study

Miodoński, A; Kuś, Jan; Nowogrodzka-Zagórska, M; Olszewski, E; Bugajski, Andrzej

doi:10.1007/978-1-4615-3488-4_25

Cited by 2 publications

(1 citation statement)

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“…Capillaries with characteristics such as larger diameter, irregular contour, constrictions and outpouchings, as seen in this study, appear to be frequent in many tumors, as described by other authors (Grunt 1992;Konerding et al 1995Konerding et al , 1998Konerding et al , 1999Miodonski et al 1992). According to Aharinejad and Bo¨ck (1994) these characteristics suggest they are fenestrated capillaries and their shape helps to identify them.…”

Section: Discussionsupporting

confidence: 66%

Angioarchitecture of squamous cell carcinoma from hamster buccal pouch: a scanning electron microscopy study

et al. 2009

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Tumoral angiogenesis has been widely studied by histochemical analysis but little has been done regarding morphology of these new vessels. The objective of this study was to perform a qualitative analysis of the angiogenic response to chemical induction with dimethylbenzanthracene (DMBA) and carbamide peroxide of squamous cell carcinoma in pouches of Syrian hamsters after different periods of treatment. Twenty-four Syrian golden hamsters, divided into three groups of eight animals each, had their right jugal pouches treated with a 5% DMBA solution three times a week and a 10% carbamide peroxide two times a week for 55, 70 and 90 days. The left pouch was considered the control. After tumor induction, five animals in each group had their pouches prepared for analysis under scanning electron microscopy and three animals for analysis under light microscopy. The control pouches showed a vascular system composed by few main vessels running parallel to the longest axis of the pouch with some branches. In the pouches submitted to tumor induction, a well-differentiated squamous cell carcinoma was present since 55 days induction in all samples. The new vascular system showed the presence of many tortuous vessels and the majority of them were veins and capillaries. Terminal loops were extremely sinuous adopting a glomerular or corkscrew shape. These tumor vessels are different from normal vessels, presenting irregular diameters, outpouchings and constrictions. Angiogenesis of sprouting and intussusceptive kind could be identified in the tumor pouches, and they were more frequent as the tumor developed.

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