Angiomatoid giant cellular blue nevus of vaginal wall associated with pregnancy

Abstract

BackgroundBlue nevi that arise from the Müllerian tract are rare melanocytic lesions. Several histopathologic variants of cellular blue nevi have been described. The angiomatoid variant is characterized by a vascular component, and is considered to be a rare variant. Few studies have explored the influence of pregnancy on melanocytic lesions.CaseA 29-year-old woman was presented with a pigmented vaginal lesion that increased gradually during pregnancy. A full term gynecologic examination showed a tumor mass protruding into the vaginal canal. The mass was resected during cesarean-section under the clinical impression of vaginal hemangioma.ResultGross examination revealed a cystic mass measuring 6.0 × 4.3 × 3.5 cm, which was filled with dark friable material. Histologically, the mass showed a subepithelial cellular proliferation of heavily pigmented dendritic melanocytes with prominent vascular stroma. Cytologic pleomorphism, junctional activity, atypical mitosis, and necrosis were not found. The proliferation was immunoreactive for HMB-45, S-100 and melan-A, and non-immunoreactive for CD34, smooth muscle actin, and AE1/AE3. The MIB-1 proliferative index was less than 1%. The patient had a postoperative course without complication.ConclusionsAngiomatoid giant cellular blue nevus arising from the vagina during pregnancy is extremely rare. The low proliferative index and absence of cytologic pleomorphism, or necrosis, supports a benign biological behavior. Clinical follow-up showed no evidence of recurrence at one year after the resection of the mass.

Large Agminated Cellular ‘Plaque-Type' Blue Nevus Surrounding the Ear: A Case and Review

“…There was a lack of cellular mitosis, however. Radiological exams (MRT) of the cerebral structures revealed a hypervascular lesion with strong contrast uptake, suggesting the angiomatoid variant of blue nevus, characterized by a vascular component [17], yet this was absent from the anatomopathological examination in our case. Regional lymph nodes were not affected.…”

“…Giant-type CBN is defined as bigger than 20 cm and is often located on the scalp [14]. Nevertheless, extracutaneous locations have been reported, such as the prostate [15], the cervix [16], the Müllerian tract [17], the oral cavity [18,19], lymph node capsules [20] and neurological structures such as meninges [21,22]. Genodermatosis such as Carney complex with GNAS mutation [23] is known to be associated with this.…”

Giant cerebriform congenital cellular blue nevus presenting as cutis verticis gyrata

“…However, CBN larger than 10 cm, namely, GCBN, is rare and few cases of this have been reported in the literature [ Table 1 ]. [ 1 2 3 4 5 ] Moreover, GCBN of this size (25 cm × 20 cm) has so far not been reported in the literature.…”

The first case of vaginal angiomatoid Spitz nevus causing vaginal bleeding

“…Al-Shraim [6] reported a similar case of angiomatoid giant cellular blue nevus of the vaginal wall. Compared to that reported by Al-Shraim [6], the lesion in our case should strong immunohistochemical positivity for CD34. Our case of angiomatoid Spitz nevus with vaginal bleeding is the first such report in Korea.…”