Large Agminated Cellular ‘Plaque-Type' Blue Nevus Surrounding the Ear: A Case and Review

Abstract

Large or giant cellular blue nevi are usually congenital and represent a challenge for the physician. Close anatomic structures may be altered by the size of the moles. In this article, we report the case of an uncommon large, agminated, cellular blue nevus of the ‘plaque type' in a 42-year-old female. Due to the risks of malignant melanoma development on a large or giant blue nevus, we highlight the importance of proper histopathological diagnosis. Furthermore, because of the possibility that the nevus may invade the bone and cerebral tissues, we discuss the indication of a radiological diagnosis. The accurate correlation to clinical and histopathological findings and appropriate multidisciplinary management can save the lives of patients.

Agminated segmental plaque‐type blue nevus associated with hypertrichosis and soft tissue hypertrophy: Report of a case and review of the literature

“…In this case, there was associated invasion of the external auditory meatus and bony aponeurosis, with associated nodular skin changes. This is in contrast to our case, in which homogeneous soft tissue thickening was seen on MRI and US scanning . Albermissen and colleagues also reported hypertrichosis associated with PTBN occurring on the dorsal hand, although unlike our case, there was no associated underlying soft tissue thickening .…”

“…The aggregation of melanocytes around appendages and neurovascular bundles is also commonly seen in BN. In our case, we found diffuse dermal melanocytosis, without the characteristic dendritic melanocytes of a single BN, within the dermis, which is consistent with findings reported in some of the previous cases of ABN …”

“…The natural history of ABN is that they follow an indolent course, although enlargement or development of new lesions within a preexisting ABN is common . Generally ABN are not associated with underlying syndromes or diagnoses; there have been cases of ABN occurring in association with other pigmented lesions, dermatomyositis, and Carney complex, but the clinical significance of these associations has not been established …”

“…Associated findings, including hypertrichosis and progressive soft tissue thickening, are rare. Only two cases have been described with underlying vascular or adnexal changes . The first was a 42‐year‐old woman with an invasive angiomatoid variant of PTBN whose vascular changes were visualized on MRI.…”

Asymptomatische, dunkelgraue, langsam progrediente Maculae und Papeln an Kopfhaut und Stirn

“…Selten treten sie in disseminierter Form oder agminiert in einem umschriebenen Areal, wie bei der hier vorgestellten Patientin, auf [5][6][7]. Bisher wurden nur wenige Fälle von agminierten Naevi bleu in der Literatur beschrieben [1, [8][9][10][11].…”