Angiolymphoid Hyperplasia with Eosinophilia

Chitrapu, Prathyusha; Patel, Mahir; Readinger, Allison; Menter, Alan

doi:10.1080/08998280.2014.11929150

Cited by 11 publications

(14 citation statements)

References 7 publications

(1 reference statement)

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“…5 ALHE commonly seen in young and middle aged men and women of Asian origin followed by Caucasians. 6,7 It typically involves the peri-auricular region, face and scalp, rarely trunk, extremities, hands, penis, oral mucosa, colon are affected. 8 On the other hand, Kimuras is more prevalent in young Asian lineage , mostly in their third decade of life.…”

Section: Discussionmentioning

confidence: 99%

Dilemma in diagnosing a post-auricular mass-angiolymphoid hyperplasia with eosinophilia versus Kimura’s disease, an infrequent encounter

Shetty

Chandrashekar

Ganesan

et al. 2021

Int J Otorhinolaryngol Head Neck Surg

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<p class="abstract">Angiolymphoid hyperplasia with eosinophilia (ALHE) and Kimura’s disease are uncommon chronic benign lesions of the skin mainly involving the head and neck regions where ALHE involves vascular and lymphocytic proliferation and Kimura’s is of inflammatory type. Dermal involvement is more in ALHE but In Kimura’s disease the lymphnodes and subcutaneous tissues are involved more. ALHE is a rare vascular tumor and Kimura’s disease is a chronic inflammatory disease. Both not only have uncertainty in etiology and pathogenesis, but also there is therapeutic dilemma in management. In this article, we describe a case of ALHE which presented to our ENT outpatient department with swelling in the left postauricular region which appeared 1.5 years back and posed a riddle in coming to correct diagnosis. On examination, a single smooth spherical swelling in upper part of post-auricular region of size 3×3 cm with well-defined edges and normal skin. Blood investigations revealed elevated absolute eosinophil count. HRCT temporal bone showed a well-defined rounded hypo-dense lesion measuring 28×23 mm with no effect of adjacent bony erosion / calcifications/ cystic changes suggestive of benign etiology. FNAC showed scantly cellular and occasionally scattered fibroblasts, pinkish stromal collagen fragments with inflammatory cells in background of haemorrhage suggestive of soft tissue neoplasm.</p>

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Section: Discussionmentioning

confidence: 99%

Dilemma in diagnosing a post-auricular mass-angiolymphoid hyperplasia with eosinophilia versus Kimura’s disease, an infrequent encounter

Shetty

Chandrashekar

Ganesan

et al. 2021

Int J Otorhinolaryngol Head Neck Surg

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“…Epithelioid haemangioma most commonly presents in mid-adult life as single or multiple erythematous/ hyperpigmented dome-shaped papules or nodules with an average size of 1 cm. 3,4,7,12,13,16,17 When multiple, they tend to be grouped, often coalescing, raising concern for a malignant process. 3,15,18 EH frequently involves the head and neck region, penis and the extremities, especially the arms and hands.…”

Section: Discussionmentioning

confidence: 99%

“…7,11 Inflammation is the second defining feature, characterised by lymphocytes, plasma cells, mast cells and varying amounts of eosinophils adjacent to the vascular proliferation. 4,9,16 The lymphocytes may form distinct follicles with or without germinal centres, particularly in long-standing lesions. 4,7 In a large series by Fetsch and Weiss 11 approximately half of the 96 EHs examined were associated with prominent lymphoid follicles and damaged medium-sized vessels.…”

Section: Discussionmentioning

confidence: 99%

Epithelioid haemangioma (angiolymphoid hyperplasia with eosinophilia subtype) involving the vermillion border of the lower lip

2021

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Epithelioid vascular tumours include benign epithelioid haemangioma (EH) and epithelioid angiomatous nodule, low-grade malignant epithelioid haemangioendothelioma and high-grade epithelioid angiosarcoma. These tumours share epithelioid cell morphologies and intracytoplasmic vacuoles, with distinction based on differing architectural and nuclear features. This report highlights a case of EH, angiolymphoid hyperplasia with eosinophilia subtype, involving the vermillion border of the lower lip in an elderly female patient. The clinical and histological features, differential diagnosis, aetiopathogenesis, molecular basis and treatment options are discussed as part of a comprehensive review of this rare entity.

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“…ALHE, on the other hand, affects all ethnic groups with no sex predominance and a mean age of incidence about 38 years [8]. A predilection for the periauricular area and scalp is also characteristic [9]. Other common areas of involvement include oral mucous membranes, pharynx, and orbit.…”

Section: Discussionmentioning

confidence: 99%

“…Patients present superficial erythematous or hyperpigmented dome-shaped dermal papules or pruritic or painful nodules of 2 to 3 cm diameter accompanied by bleeding. Lesions do not resolve spontaneously [9]. Regional lymphadenopathy, serum eosinophilia, and elevated IgE levels are uncommon in ALHE [1].…”

Section: Discussionmentioning

confidence: 99%

The Value of Imaging Diagnostics in the Kimura’s Disease

Clarós¹,

Clarós²

2019

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Kimura's disease (KD) is a benign chronic inflammatory disease of subcutaneous tissue of unknown etiology. Although it is regularly reported and is now clearly defined, it still constitutes a diagnostic challenge, as its resemblance with benign and malignant diseases can make the diagnosis difficult, requiring the skills of experienced pathologists. We report here our experience with Kimura's Disease, presenting two cases of female patients from Saudi Arabia with the pathology located within the orbit who were successfully treated surgically at Clarós Clinic. Afterwards we review the literature on the subject and discuss diagnostic process with particular emphasis on imaging diagnostic and treatment options to improve our understanding of this mysterious disease.

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Angiolymphoid Hyperplasia with Eosinophilia

Cited by 11 publications

References 7 publications

Dilemma in diagnosing a post-auricular mass-angiolymphoid hyperplasia with eosinophilia versus Kimura’s disease, an infrequent encounter

Dilemma in diagnosing a post-auricular mass-angiolymphoid hyperplasia with eosinophilia versus Kimura’s disease, an infrequent encounter

Epithelioid haemangioma (angiolymphoid hyperplasia with eosinophilia subtype) involving the vermillion border of the lower lip

The Value of Imaging Diagnostics in the Kimura’s Disease

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