Angiolymphoid hyperplasia with eosinophilia: Evidence for a T-cell lymphoproliferative origin

Kempf, Werner; Haeffner, A; Zepter, Karoline; Sander, Christian; Flaig, Michael J.; Mueller, Beatrix; Panizzon, Renato G.; Hardmeier, T; Adams, Volker; Burg, Günter

doi:10.1053/hupa.2002.128247

Cited by 104 publications

(77 citation statements)

References 28 publications

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“…It is interesting to note that most of the lymphocytes in ALHE are of T-cell lineage 34 and that, as recently reported, 29 5 of 7 ALHE lesions contained a monoclonal T-cell population, suggesting that ALHE or a subset of it might represent a low-grade T-cell LPD. If the latter findings are confirmed, they raise the intriguing possibility of a relationship between the eosinophil-rich CD30+ LPDs and ALHE.…”

Section: Discussionmentioning

confidence: 91%

“…26 ALHE is primarily a skin disease, which belongs to the general category of "epithelioid (histiocytoid) hemangioma." [28][29][30][31][32][33][34] This lesion, first described in 1969, 28 shows angioproliferation with an inflammatory infiltrate in which lymphocytes and eosinophils predominate. ALHE can rarely involve the oral mucosa, [30][31][32][33] and such cases conceivably might be interpreted as TEG.…”

Section: Discussionmentioning

confidence: 96%

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Eosinophil-Rich CD30+ Lymphoproliferative Disorder of the Oral Mucosa

et al. 2004

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We describe 3 patients who had oral mucosal lesions with features of traumatic eosinophilic granuloma (TEG) and containing CD30+ atypical cells. In 1 patient, the oral lesion was followed by skin nodules. All lesions were evaluated histologically, by immunohistochemical analysis, and by polymerase chain reaction (PCR) analysis of the T-cell receptor (TCR) gamma chain gene. All oral lesions were characterized by a dense and deeply infiltrative lymphoproliferation, showing epitheliotropism and massive eosinophilia. They contained atypical large lymphoid cells, which expressed T-cell markers and CD30. PCR analysis showed a monoclonal rearrangement of the TCR gamma chain gene in all lesions and, in 1 patient, the same rearrangement in the oral and cutaneous specimens. The lesions in these patients seem to be the oral counterpart of the spectrum of primary cutaneous CD30+ lymphoproliferative disorders and should be recognized as such to avoid a diagnosis of large T-cell lymphoma and possible consequent overtreatment. However, they represent only a subset among several others within the complex and heterogeneous category of disorders referred to as TEG.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 96%

Eosinophil-Rich CD30+ Lymphoproliferative Disorder of the Oral Mucosa

et al. 2004

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“…[15][16][17] Both diseases have J AM ACAD DERMATOL VOLUME 62, NUMBER 2 also been associated with the concurrent and or subsequent development of T-cell lymphoma; however, actual neoplastic evolution of the lymphocytic infiltrates in lesions of ALHE and Kimura disease has not been shown. [18][19][20][21][22][23][24][25] Although there have been several reports of both entities occurring in a single patient, 12,26,27 most authors view ALHE and Kimura disease as two distinct disorders. ALHE occurs in young to middleaged women, and presents with multiple small (\2 cm) erythematous dermal papules or nodules.…”

Section: Discussionmentioning

confidence: 99%

Juvenile temporal arteritis

Kolman¹,

Spinelli²,

Magro³

2010

Journal of the American Academy of Dermatology

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“…[8] Interestingly, Cham et al . [9] showed that the ALHE lymphoid component may contain large activated CD30+ cells, suggesting that a subset of it might represent a form of low-grade T-cell LPD.…”

Section: Discussionmentioning

confidence: 99%

Traumatic ulcerative granuloma with stromal eosinophilia of the palate showing an angiocentric/angiodestructive growth pattern

et al. 2012

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Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a benign, self-limiting lesion of the oral mucosa with unknown pathogenesis. A 65-year-old male patient presented with an ulcerative palate lesion, which on microscopic examination exhibited an exuberant polymorphic lymphoid proliferation, numerous eosinophils, and extensive vascular destruction. The atypical lymphoid cells infiltrating the medium-sized vessels showed positivity for CD3, CD30, and granzyme B, implicating an activated cytotoxic T-cell phenotype. The lesion diagnosed as TUGSE achieved complete resolution within 3 months. This unusual presentation has expanded the spectrum of oral CD30+ T-cell atypical infiltrates and must be distinguished from lymphomas showing angiocentric/angiodestructive growth pattern.

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Angiolymphoid hyperplasia with eosinophilia: Evidence for a T-cell lymphoproliferative origin

Cited by 104 publications

References 28 publications

Eosinophil-Rich CD30+ Lymphoproliferative Disorder of the Oral Mucosa

Eosinophil-Rich CD30+ Lymphoproliferative Disorder of the Oral Mucosa

Juvenile temporal arteritis

Traumatic ulcerative granuloma with stromal eosinophilia of the palate showing an angiocentric/angiodestructive growth pattern

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