Angiogenic footprints in diabetic retinopathy: opportunities for drug development

Bhatia, Shiveena; Babbar, Ritchu; Zehravi, Mehrukh; Singh, Balbir; Chandel, Parteek; Hasan, Mohammad Mehedi; Arora, Raksha; Gill, Naresh Singh; Sindhu, Rakesh K.; Ahmad, Zubair; Khan, Farid; Rahman, Habibur

doi:10.1080/02648725.2022.2102880

Cited by 5 publications

(1 citation statement)

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“…This dysfunction leads to increased vascular permeability and retinal ischemia. Increased permeability leads to macular oedema, while retinal ischemia triggers angiogenesis and retinal neovascularization 3 . Recent studies suggest novel molecular processes that may influence the development and severity of diabetic retinopathy.…”

Section: Introductionmentioning

confidence: 99%

Serum α-Klotho and fibroblast growth factor 23 levels are not associated with non-proliferative diabetic retinopathy in type 1 diabetes mellitus

Oner,

Dogan,

Tuzun

et al. 2024

Sci Rep

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Diabetic retinopathy is a commonly observed cause of blindness and is a common problem in individuals with diabetes. Recent investigations have showed the capability of serum α-Klotho and FGF 23 in mitigating the effects of diabetic retinopathy. This study aimed to discover the correlation between FGF 23, α-Klotho, and diabetic retinopathy in type 1 diabetics. This case–control study included 63 diabetic patients and 66 healthy controls. Following an overnight duration of fasting, morning blood samples were taken from both the patient and the control groups. The serum concentrations of α-Klotho and FGF 23 were quantified. An experienced ophthalmologist inspected the retinopathy. All participants in this study have moderate non-proliferative retinopathy. A p value under 0.05 was considered statistically significant. The mean α-Klotho level for retinopathic diabetic patients was 501.7 ± 172.2 pg/mL and 579.6 ± 312.1 pg/mL for non-retinopathic diabetic patients. In comparison, α-Klotho level of the control group was 523.2 ± 265.4 pg/mL (p = 0.531). The mean of FGF 23 level did not demonstrate a significant difference (p = 0.259). The mean FGF 23 level were 75.7 ± 14.0 pg/mL, 74.0 ± 14.8 pg/mL and 79.3 ± 14.4 pg/mL in groups, respectively. In conclusion, there was no significant difference in FGF 23 and α-Klotho levels between type 1 diabetics with and without retinopathy when compared to the control group.

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Section: Introductionmentioning

confidence: 99%