Angiogenic defects in preeclampsia: What is known, and how are such defects relevant to preeclampsia pathogenesis?

Kanasaki, Keizo; Kanasaki, Megumi

doi:10.14390/jsshp.1.57

Cited by 4 publications

(6 citation statements)

References 78 publications

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“…It was found that after supplementation, magnesium levels were 2.12±0.18 mg/dL with an increase in magnesium levels of 0.34 mg/dL. 14 In this study it was found that all respondents who received magnesium supplementation experienced an increase in blood magnesium levels when re-examination was carried out after the patient gave birth. There are respondents who experience an increase in magnesium more than the average number of increases in all respondents.…”

Section: Discussionmentioning

confidence: 57%

“…13 Dovy's research in 2020 in Padang regarding the effect of magnesium supplementation on pregnancy outcome, also found magnesium levels blood in pregnant women is 1.78 ± 0.11 mg/dL. 14 Patients who were given magnesium supplementation were then re-examined for magnesium levels, then the blood magnesium level after the supplementation was 2.14 ± 0.17 mg/dL, with a mean increase of 0.37 ± 0.17 mg/dL. This result is in line with Dovy's research which gave magnesium supplementation to the respondents.…”

Section: Discussionmentioning

confidence: 98%

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The Correlation of the Average Increase in Blood Magnesium Levels with the Incidence of Preeclampsia After Magnesium Supplementation in Hypomagnesemic Pregnant Women at the Padang City Health Center

Utama

Djanas

2021

AOJ

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Preeclampsia is a hypertensive disorder in pregnancy that occurs in 5-10% of pregnancies and occurs after 20 weeks of gestation and recovers spontaneously after delivery. Several studies have stated that one of the risks of hypertension in pregnancy is related to magnesium homeostasis. Magnesium plays an important role in forming new tissues (maternal and fetal). Pregnant women need a higher intake of magnesium than non-pregnant women of the same age. Magnesium deficiency during pregnancy not only causes problems for the nutrition of pregnant women and fetuses, but also associated with the occurrence of preeclampsia, preterm labor and muscle cramps during pregnancy. This study aims to determine the relationship between the average increase in blood magnesium levels with the incidence of preeclampsia in hypomagnesemic pregnant women.Keywords: preeclampsia, hypertension, blood magnesium levels

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 98%

The Correlation of the Average Increase in Blood Magnesium Levels with the Incidence of Preeclampsia After Magnesium Supplementation in Hypomagnesemic Pregnant Women at the Padang City Health Center

Utama

Djanas

2021

AOJ

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“…As we mentioned, the rats deficient in COMT showed lower levels of VEGF and elevated sFlt-1. It has been reported that COMT deficiency induces defects in both angiogenesis and the placenta by dysfunction of angiogenic factors ( 42 ). Our results from the COMT-I model showed that disrupting angiogenesis in the placenta may lead to the overproduction of P5 and DHEA through the regulation of CYP11A1 and CYP19A1.…”

Section: Discussionmentioning

confidence: 99%

Comparison of steroid hormones in three different preeclamptic models

Shin

Jeong

et al. 2021

Mol Med Rep

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Preeclampsia (PE) is a complication of pregnancy and is characterized by hypertension and proteinuria, threatening both the mother and the fetus. However, the etiology of PE has not yet been fully understood. Since the imbalance of steroid hormones is associated with the pathogenesis of PE, investigating steroidogenic mechanisms under various PE conditions is essential to understand the entire spectrum of pregnancy disorders. Therefore, the current study established three PE in vitro and in vivo models, and compared the levels of steroid hormones and steroidogenic enzymes within them. In cellular PE models induced by hypoxia, N-nitro-L-arginine methyl ester hydrocholride (L-NAME) and catechol-o-methyltransferase inhibitor, the levels of steroid hormones, including pregnenolone (P5), progesterone (P4), dehydroepiandrosterone (DHEA) and testosterone tended to decrease during steroidogenesis. Injection of L-NAME in pregnant rats led to a reduction in the levels of estradiol and P4 through regulation of cholesterol side-chain cleavage enzyme (CYP11A1) and 3β-hydroxysteroid dehydrogenase/δ5 4-isomerase type 1 (HSD3B1), whereas rats treated with COMT-I exhibited elevated levels of P5 and DHEA by regulation of the CYP11A1 and aromatase cytochrome P450 (CYP19A1) in the placenta and plasma. The reduced uterine perfusion pressure operation decreased CYP11A1 and increased CYP19A1 expression in placental tissues, whereas steroid hormone levels were not altered. In conclusion, the results of the present study suggest that the induction of PE conditions dysregulates the steroid hormones via regulation of steroidogenic enzymes, depending on specific PE symptoms. These findings can contribute to the development of novel diagnostic and therapeutic modalities for PE, by monitoring and supplying appropriate levels of steroid hormones.

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“…Hypothetical models in the interaction of hyperhomocysteinemia and preeclampsia onset via COMT deficiency was proposed by Kanasaki K, et al 9) . Women with SNPs associated with low COMT enzymatic activity can exhibit severely suppressed COMT activity, leading to preeclampsia.…”

Section: Figure-3 Site Of Action Of Comt and Role Of 2-methoxyestradiolmentioning

confidence: 99%

The Fascinating Field of Obstetrics and Gynecology

Takeda

2017

Juntendo Medical Journal

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Juntendo, which has a history dating back to the Edo era, has made major contributions to Japanʼs healthcare. In the field of obstetrics and gynecology, this school has provided various pioneering innovations and educational efforts including the development of a surgical technique for ovarian cystoma, implementation of the first cesarean section in Japan, and the introduction of painless delivery to this country. On the occasion of my retirement, Iwould like to highlight certain topics pertaining to clinical practice and research in obstetrics and gynecology during the past decade and how fascinating this field of medicine truly is.

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Angiogenic defects in preeclampsia: What is known, and how are such defects relevant to preeclampsia pathogenesis?

Cited by 4 publications

References 78 publications

The Correlation of the Average Increase in Blood Magnesium Levels with the Incidence of Preeclampsia After Magnesium Supplementation in Hypomagnesemic Pregnant Women at the Padang City Health Center

The Correlation of the Average Increase in Blood Magnesium Levels with the Incidence of Preeclampsia After Magnesium Supplementation in Hypomagnesemic Pregnant Women at the Padang City Health Center

Comparison of steroid hormones in three different preeclamptic models

The Fascinating Field of Obstetrics and Gynecology

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