Angiogenic and MMPs modulatory effects of icariin improved cutaneous wound healing in rats

Singh, Wangkheirakpam Ramdas; Devi, Hijam Shila; Kumawat, Sanjay; Sadam, Abdul; Appukuttan, A.V.; Patel, M.; Lingaraju, Madhu Cholenahalli; Singh, Thakur Uttam; Kumar, Dinesh

doi:10.1016/j.ejphar.2019.172466

Cited by 27 publications

(17 citation statements)

References 38 publications

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“… 138 Matrix metalloproteinase (MMP)-2 mediates the degradation of tight junction proteins such as occludin and claudin-5. 139 Icariin protects the BBB by reducing MMP-2 protein level, 140 , 141 a mechanism that may be relevant to the treatment of ischemic stroke. Cyclin-dependent kinase (CDK)5, is known to promote ischemic injury and stroke-induced neuronal death and potentiates the excitotoxicity caused by ischemia.…”

Section: Therapeutic Mechanisms Of Icariin In Nervous System Diseases: Literature Review and Network Pharmacology Analysismentioning

confidence: 99%

Icariin, an Up-and-Coming Bioactive Compound Against Neurological Diseases: Network Pharmacology-Based Study and Literature Review

Wang¹,

Ma²,

Zeng³

et al. 2021

DDDT

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Section: Therapeutic Mechanisms Of Icariin In Nervous System Diseases: Literature Review and Network Pharmacology Analysismentioning

confidence: 99%

Icariin, an Up-and-Coming Bioactive Compound Against Neurological Diseases: Network Pharmacology-Based Study and Literature Review

Wang¹,

Ma²,

Zeng³

et al. 2021

DDDT

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“…Histopathological scores of HE slices were employed to a semiquantitative evaluation of wound healing according to the criterion of Eldad et al (1998). Collagen volume fraction (CVF) was utilized to assess collagen formation (Singh et al, 2019). Specifically, 6 regions of interest (ROIs) per HPF were recorded under a microscope.…”

Section: Hematoxylin-eosin and Masson's Trichrome Stainingmentioning

confidence: 99%

Copper Sulfide Nanoparticles-Incorporated Hyaluronic Acid Injectable Hydrogel With Enhanced Angiogenesis to Promote Wound Healing

Zhou

Cen

et al. 2020

Front. Bioeng. Biotechnol.

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Skin wound caused by trauma, inflammation, surgery, or burns remains a great challenge worldwide since there is no effective therapy available to improve its clinical outcomes. Herein, we report a copper sulfide nanoparticles-incorporated hyaluronic acid (CuS/HA) injectable hydrogel with enhanced angiogenesis to promote wound healing. The prepared hydrogel could not only be injected to the wound site but also exhibited good photothermal effect, with temperature increasing to 50 • C from room temperature after 10 min of near-infrared light irradiation. The cell culture experiments also showed that the hydrogel has no cytotoxicity. In the rat skin wound model, the hydrogel treated wounds exhibited better healing performances. Masson's trichrome staining suggested that collagen deposition in wounds treated with the hydrogel was significantly higher than other groups. The immunohistochemical staining showed that the hydrogel can effectively upregulate the expression of vascular endothelial growth factor (VEGF) in the wound area at the incipient stage of healing, and the CD 31 immunofluorescence staining confirmed the enhanced angiogenesis of the hydrogel. Taken together, the prepared CuS/HA hydrogel can effectively increase the collagen deposition, upregulate the expression of VEGF, and enhance the angiogenesis, which may contribute to promote wound healing, making it a promising for application in treating skin wound.

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“…Soft tissue toxicity is one of the hypotheses explaining the pathogenesis of MRONJ and promotive effect on soft tissue healing of icarrin was noted in the present study: the area of the wound in icarrin group was significantly smaller than the untreated group. The stimulative effect of icarrin on wound healing have been confirmed by other studies 13,20,21 and this may correlate to upregulated expression of VEGF which correlates to angiogenesis, 22 activated the MEK/ERK and PI3K/Akt/eNOS‐dependent signal pathways and promoted differention of keratinocyte involved in wound healing 13,20,23 . Angiogenesis is also an important factor in bone healing 12 and studies have shown the promising effect of icarrin on bone healing via promoting angiogenesis 11,24 .…”

Section: Discussionmentioning

confidence: 73%

Management of medication‐related osteonecrosis of jaw: Comparison between icariin and teriparatide in a rat model

Liu

Mattheos

Deng

et al. 2020

Journal of Periodontology

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Background The aim of this study is to compare the effects of icariin and teriparatide on the treatment of medication‐related osteonecrosis of the jaw (MRONJ) using a rat model. Methods Fifty rats undergoing ovariectomy were randomly assigned to control group (n = 10) and the MRONJ model group (n = 40). Zoledronic acid (0.2 mg/kg) and dexamethasone (2 mg/kg) were injected into rats in the model group for 8 weeks while saline was applied in control group, then all rats underwent tooth extraction and bone defect. Eight weeks later, rats diagnosed with MRONJ (n = 33) were randomly distributed to icariin (n = 11), teriparatide (n = 11), and the untreated (n = 11) group, and rats received daily 150 mg/kg icariin, 20 µg/kg teriparatide, and no intervention, respectively, for 8 weeks. Then, mandibulars were dissected for later examination. Results Rats diagnosed with MRONJ (33/40) demonstrated significantly larger area of soft tissue wound and necrotic bone with higher ratio of empty bone lacuna. Area of soft tissue wound and ratio of empty bone lacuna were significantly decreased in the icariin group compared with the untreated group, while teriparatide group revealed significantly higher ratio of receptor activator of NF‐kB ligand (RANKL)‐positive osteocytes, smaller area of necrotic bone and lower ratio of empty lacuna. The two agents were related to higher expression of BMP‐2 in osteocytes but were not statistically significant. Conclusions Icariin benefits MRONJ in terms of the area of soft tissue wound and ratio of empty lacuna. Teriparatide activates expression of RANKL and reduces the area of bone necrosis and ratio of empty lacuna in a MRONJ lesion. The data suggest possible healing improvement in patients with MRONJ and further studies to prove the efficacy of icariin.

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Angiogenic and MMPs modulatory effects of icariin improved cutaneous wound healing in rats

Cited by 27 publications

References 38 publications

Icariin, an Up-and-Coming Bioactive Compound Against Neurological Diseases: Network Pharmacology-Based Study and Literature Review

Icariin, an Up-and-Coming Bioactive Compound Against Neurological Diseases: Network Pharmacology-Based Study and Literature Review

Copper Sulfide Nanoparticles-Incorporated Hyaluronic Acid Injectable Hydrogel With Enhanced Angiogenesis to Promote Wound Healing

Management of medication‐related osteonecrosis of jaw: Comparison between icariin and teriparatide in a rat model

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