Angiogenesis in bronchial circulatory system  after unilateral pulmonary artery obstruction

Charan, Nirmal B.; Carvalho, Paula

doi:10.1152/jappl.1997.82.1.284

Cited by 76 publications

(55 citation statements)

References 10 publications

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“…In human disease, as well as in animal models, obstruction of the pulmonary vasculature results in rapid and sustained systemic neovascularization of the lung (4,6,7,10,18). Both bronchial and intercostal arteries participate by proliferating and perfusing lung vascular networks.…”

Section: Discussionmentioning

confidence: 99%

“…New vessel formation follows an organized progression of changes, including matrix dissolution, cell migration, and proliferation (3). Pulmonary ischemia resulting from chronic pulmonary embolism or other forms of pulmonary artery obstruction lead to proliferation of the systemic circulation within and surrounding the lung (4,7,8,18). The bronchial and intercostal vasculatures respond to pulmonary ischemia due to pulmonary artery obstruction with rapid neovascularization.…”

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confidence: 99%

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Pulmonary ischemia induces lung remodeling and angiogenesis

Wagner

Petrache

Schofield

et al. 2006

Journal of Applied Physiology

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Mitzner. Pulmonary ischemia induces lung remodeling and angiogenesis. J Appl Physiol 100: 587-593, 2006. First published October 6, 2005 doi:10.1152/japplphysiol.00029.2005.-Cellular remodeling during angiogenesis in the lung is poorly described. Furthermore, it is the systemic vasculature of the lung and surrounding the lung that is proangiogenic when the pulmonary circulation becomes impaired. In a mouse model of chronic pulmonary thromboembolism, after left pulmonary artery ligation (LPAL), the intercostal vasculature, in proximity to the ischemic lung, proliferates and invades the lung (12). In the present study, we performed a detailed investigation of the kinetics of remodeling using histological sections of the left lung of C57Bl/6J mice after LPAL (4 h to 20 days) or after sham surgery. New vessels were seen within the thickened visceral pleura 4 days after LPAL predominantly in the upper portion of the left lung. Connections between new vessels within the pleura and pulmonary capillaries were clearly discerned by 7 days after LPAL. The visceral pleura and the lung parenchyma showed intense tissue remodeling, as evidenced by markedly elevated levels of both proliferating cell nuclear antigen and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling positive cells. Rapidly dividing cells were predominantly macrophages and type II pneumocytes. The increased apoptotic activity was further quantified by caspase-3 activity, which showed a sixfold increase relative to naive lungs, by 24 h after LPAL. Because sham surgeries had little effect on measured parameters, we conclude that both thoracic wound healing and pulmonary ischemia are required for systemic neovascularization.histology; apoptosis; caspase-3 THE PROCESS OF NEW VESSEL growth induced by tissue ischemia requires an orchestrated series of local cellular events. New vessel formation follows an organized progression of changes, including matrix dissolution, cell migration, and proliferation (3). Pulmonary ischemia resulting from chronic pulmonary embolism or other forms of pulmonary artery obstruction lead to proliferation of the systemic circulation within and surrounding the lung (4,7,8,18). The bronchial and intercostal vasculatures respond to pulmonary ischemia due to pulmonary artery obstruction with rapid neovascularization. It is interesting to note that the pulmonary vasculature appears not to be responsive in this setting. In general, the pulmonary artery is not proangiogenic, except in rare circumstances, as a secondary source of perfusion in some lung carcinomas (11). Unlike other organs, the lung is unique in that pulmonary ischemia is not accompanied by tissue hypoxia. Our laboratory previously developed a mouse model of lung angiogenesis and quantified new systemic perfusion of the lung following left pulmonary artery ligation (LPAL) (12). Rapid neovascularization occurs, and systemic perfusion of the lung can be measured 5 days after pulmonary artery ligation. However, unlike most other species, new vessel growth appear...

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Pulmonary ischemia induces lung remodeling and angiogenesis

Wagner

Petrache

Schofield

et al. 2006

Journal of Applied Physiology

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“…The human lung is supplied by both the pulmonary and the bronchial circulation. Neovascularization and development of anastamoses between these circuits control pulmonary vascular resistance, necessary to maintaining blood flow to the metabolically active lung tissue in the context of injury and repair (78)(79)(80)(81). Compensatory neovascularization of up to 30% of the original pulmonary blood flow can occur in the bronchial circulation in all mammals in response to marked increases in pulmonary vascular resistance (81), and the mouse systemic circulation can supply 15% of the pulmonary flow within days after pulmonary artery ligation, a process that is associated with up-regulation of ELR+ CXC chemokines but not VEGF (82,83).…”

Section: Chemokine-induced Angiogenesis In Inflammatory and Fibroprolmentioning

confidence: 99%

Chemokines as mediators of angiogenesis

Mehrad¹,

Keane²,

Strieter³

2007

Thromb Haemost

181

145

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SummaryChemokines were originally described as cytokines that mediate leukocyte recruitment to sites of inflammation. Members of a subgroup of chemokines, the CXC family, also play a critical role in both physiologic and pathologic angiogenesis, including in the context of chronic inflammation, fibrosis, and malignancy. A unique feature of this family of cytokines is that, on the basis of their structure and receptor binding, individual ligands display either angiogenic or angiostatic biological activity in the regulation of angiogenesis. In this review, we summarize the key literature in this growing field.

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“…But besides its normal function, the vessels of the bronchial circulation can play an important role in various pathologies of the lung, partly because they can effectively form anastomoses with the pulmonary precapillary microvessels, such as may occur with congenital heart disease and pulmonary edema [2] or pulmonary arterial occlusion and embolism [3,4]. Furthermore, it has been shown that primary bronchogenic carcinomas and bronchial adenomas derive a significant portion of their blood supply from the bronchial circulation [5][6][7][8] and that blood flow within the bronchial circulation is correspondingly increased [9].…”

Section: Introductionmentioning

confidence: 99%

“…After ligation of the left pulmonary artery (LPA), the bronchial circulation of the left lung has been shown to develop in sheep [3], dogs [10][11][12][13][14], rats [15][16][17][18], and mice [19,20] in an attempt to compensate for the lack of perfusion via the pulmonary circulation. Commonly, ligation of the LPA has been used because it is generally more accessible than the right lung, and in the rat, the left lung accounts for only one third of the total lung capacity, which can be partially compensated for by the right lung.…”

Section: Introductionmentioning

confidence: 99%