Angiogenesis and extracellular matrix remodelling in bronchioloalveolar carcinomas: distinctive patterns in mucinous and non‐mucinous tumours

Guedj, Nathalie; Couvelard, Anne; Arcangeli, G.; Dubois, Sylvie; Thabut, Gabriel; Lesèche, Guy; Fournier, Marcia V.; Degott, Claude; Groussard, O

doi:10.1111/j.1365-2559.2004.01803.x

Cited by 18 publications

(6 citation statements)

References 33 publications

(33 reference statements)

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“…For example, compared to mucinous BAC, nonmucinous BAC is more commonly associated with neoangiogenesis and remodeling of extracellular matrix (26), increased expression of EGFR and erbB2 (27), and mutations in p53 (28). Akt has been linked to each of these processes, as it is required for some types of experimental angiogenesis (29), is activated by EGFR and erbB2 (30,31), and has reciprocal regulation of p53 function (32,33).…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of clinical factors and Akt activation in patients with bronchioloalveolar carcinoma

et al. 2007

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Purpose: Lung cancer is the leading cause of cancer related mortality in the world. BAC is a subset of NSCLC that has recently gained attention because of distinct biologic and clinical features, increased incidence, and enhanced responsiveness to new therapies such as epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). However, prognostic features for BAC have not been well defined. Because activation of Akt is highly prevalent and a poor prognostic factor for other types of NSCLC, we assessed the prognostic significance of clinical features and Akt activation in patients with BAC.Methods: 46 cases of BAC in Iceland were classified according to WHO 1999 criteria. Akt activation was assessed using two phospho-specific antibodies against Akt (S473 and T308) in immunohistochemical analysis. Associations between ordered Akt levels and other dichotomous parameters were evaluated using an exact Cochran-Armitage test for trend. Survival was analyzed by the Kaplan-Meier method and log-rank test, with hazard ratios (HR) determined by Cox proportional hazard models. The Cox model was also used to assess the joint effect of multiple factors on survival when they are considered simultaneously.Results: Age and histology (mucinous vs. non-mucinous) were not associated with survival. Activation of Akt was highly prevalent in BAC, with only 2 out of 46 patients exhibiting negative staining with either antibody. Moderate to high Akt activation was observed in 63% of cases and was associated with non-mucinous histology. Akt activation was not associated with differences in survival or smoking status. In contrast, Cox model analysis revealed that male gender (HR 2.24, 95% CI 1.07-4.71, p=0.032), advanced stage (III or IV) (HR 2.17, p=0.049), and smoking status (HR 6.89, 95% CI 1.49-31.88, p=0.013) were associated with a worse prognosis. Conclusions:Male gender, advanced stage, and especially smoking status (but not Akt activation) are potentially important prognostic features for BAC. These features should be considered in the design and interpretation of clinical trials that enroll BAC patients.

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Section: Discussionmentioning

confidence: 99%

Prognostic significance of clinical factors and Akt activation in patients with bronchioloalveolar carcinoma

et al. 2007

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“…This might explain why AAH can persist for several years without progression (86). In addition there seems to be a difference between mucinous and non-mucinous adenocarcinomas with respect to neoangiogenesis (87). Increased angiogenesis itself in invasive adenocarcinomas has a negative impact on survival and progression of these patients (88).…”

Section: Therapy Relevant Molecular Changes In Pulmonary Carcinomas 7mentioning

confidence: 99%

Molecular diagnosis in lung diseases

Calabrese¹

2015

Front Biosci

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The development of different molecular biology techniques in the past decade has led to an explosion of new research in molecular pathology with consequent important applications to diagnosis, prognosis, and therapeutics, as well as a clearer concept of the disease pathogenesis. Many methods used in molecular pathology are now validated and used in several areas of pathological diagnosis, particularly on infectious and neoplastic diseases. The spectrum of infectious diseases, especially lung infective diseases, is now broadening and modifying, thus the pathologist is increasingly involved in the diagnosis of these pathologies. The precise tissue characterization of lung infections has an important impact on specific therapeutic treatment. Increased knowledge of significant alterations in lung cancer has led today to a better understanding of the pathogenic substrate underlying the development, progression and metastasis of neoplastic processes. Molecular tests are now routinely performed in different lung tumors allowing a more precise patient stratification in terms of prognosis and therapy. This review focuses on molecular pathology of the principal infective lung diseases and tumors.

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“…However, GGOs can result from inflammation, hemorrhage, or fibrosis. Attempts to evaluate contrast enhancement of GGOs may be helpful to further characterize such lesions because pathologic studies [ 20 , 21 ] showed increased blood vessel density in adenocarcinoma, including bronchiolo-alveolar carcinoma, and lesion enhancement is assumed to suggest malignancy. Practically, however, evaluating the contrast enhancement of GGOs is challenging.…”

Section: Characterization Of Lung Nodulesmentioning

confidence: 99%

Dual-energy CT imaging of thoracic malignancies

Zhang¹,

Yang²,

Wu³

et al. 2013

Cancer Imaging

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Computed tomography (CT) plays a pivotal role in the detection, characterization, and staging of lung cancer and other thoracic malignancies. Since the introduction of clinically viable dual-energy CT techniques, substantial evidence has accumulated on the use of this modality for imaging chest malignancies. This article describes the principles of dual-energy CT along with suitable image acquisition, reconstruction, and postprocessing strategies for oncologic applications in the chest. The potential of dual-energy CT techniques for the detection, characterization, staging, and surveillance of chest malignancy, as well as the limitations of this modality are discussed.

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Angiogenesis and extracellular matrix remodelling in bronchioloalveolar carcinomas: distinctive patterns in mucinous and non‐mucinous tumours

Cited by 18 publications

References 33 publications

Prognostic significance of clinical factors and Akt activation in patients with bronchioloalveolar carcinoma

Prognostic significance of clinical factors and Akt activation in patients with bronchioloalveolar carcinoma

Molecular diagnosis in lung diseases

Dual-energy CT imaging of thoracic malignancies

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