Angioedema–Urticaria Due to Acitretin

Solak, Berna; Metin, Nurcan; Erdem, Mustafa Teoman

doi:10.1097/mjt.0000000000000081

Cited by 4 publications

(2 citation statements)

References 5 publications

(7 reference statements)

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“…Angioedema has been previously reported in four patients treated with oral retinoids: isotretinoin (two cases without urticaria and two cases with associated urticaria) and in two patients treated with oral acitretin (one case with and one case without urticaria) (7)(8)(9)(10)(11).…”

Section: Discussionmentioning

confidence: 99%

Angioedema without urticaria caused by oral acitretin

Pasmatzi

Monastirli

Badavanis

et al. 2017

Acta Dermatovenerologica Alpina Pannonica Et Adriatica

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The efficacy of oral acitretin in the systemic treatment of severe and recalcitrant dermatoses has been established in a large number of clinical trials. Its mucocutaneous and ocular adverse reactions are common or relatively common, whereas systemic side effects are either uncommon or rare and include teratogenesis, hyperlipidemia, hepatotoxicity, intracranial hypertension, myopathy, and peripheral neuropathy. Angioedema is a term used to describe an acute, solitary or multiple, circumscribed, and non-pitting mucocutaneous swelling that affects the dermis and the subcutaneous tissue, lasts 24 to 72 hours, and may become potentially life-threatening when the pharynx and/or the larynx are involved. We report here the case of a 51-year old female psoriatic patient with angioedema (without urticaria) due to oral acitretin, confirmed by a positive oral provocation test. To the best of our knowledge, this is the second description of such an adverse reaction to acitretin.

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Section: Discussionmentioning

confidence: 99%

Angioedema without urticaria caused by oral acitretin

Pasmatzi

Monastirli

Badavanis

et al. 2017

Acta Dermatovenerologica Alpina Pannonica Et Adriatica

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“…Psoriasis is a Th1 dominant condition, however, during pregnancy a temporarily switch to a Th2 system occurs and this prevents Th1 response; as a result, psoriasis improves during pregnancy [22]. Acitretin is an oral retinoid, which has various side effects, such as teratogenicity, cheilitis, xerosis, dyslipidemia, and photosensitivity [23]. Fetal abnormalities that occur due to oral use of retinoids include craniofacial, musculoskeletal and central nervous system anomalies [24][25].…”

Section: Vitamin a And Management Of Pregnancy In Psoriatic Womenmentioning

confidence: 99%

A Review of the Role of Vitamins in Psoriasis in Pregnancy

Güngör¹

2016

Int. J. Gynecol. Obstet. & Neona. Care

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Psoriasis is an immune mediated chronic inflammatory disorder. Psoriasis treatment regimen is an immune regulation and inhibition of the cell cycle to prevent hyper proliferation of keratinocytes. Psoriasis does not affect the reproductive ability of patients; however, psoriatic women in reproductive period should be aware of the side effects of psoriatic medication. Understanding the molecular mechanisms beyond Psoriasis is crucial in developing effective treatment options for Psoriasis and preventing birth defects such as spontaneous abortions, intermittent fetal bradycardia, malformations and miscarriages. Vitamin A and vitamin D are the skin hormones that regulate the cell cycle of the keratinocytes. Vitamin A and D deliveries are extensively used in psoriasis treatment. Vitamin A is important for neuronal development; however, excessive use of vitamin A is teratogenic. Vitamin D is useful for Psoriasis treatment and is required for bone integrity. Vitamin D is also important for women's fertility. Both vitamin A and vitamin D play a pleiotropic role in metabolism by regulating different gene expressions. Thus, the use of the vitamins or their derivatives in psoriasis treatment is vital for the fetus development. In this review we focus on the vitamin A and D metabolism, particularly molecular and genetic aspects of psoriasis treatment during pregnancy.

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Acitretin

2016

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Angioedema–Urticaria Due to Acitretin

Cited by 4 publications

References 5 publications

Angioedema without urticaria caused by oral acitretin

Angioedema without urticaria caused by oral acitretin

A Review of the Role of Vitamins in Psoriasis in Pregnancy

Acitretin

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