Angioedema and systemic sclerosis

Bertinotti, Luca; Miniati, Irene; Cerinic, Marco Matucci

doi:10.1080/713798348

Cited by 4 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, in most cases, aetiology of chronic urticaria is unknown; it is referred to as chronic idiopathic urticaria and in over one-third of cases the autoimmune pathogenic mechanism is proposed [2,3]. Interestingly, altered functions of the neuro-endocrine-immune system due to stress and other factors seem to appear as a very interesting theory for urticaria pathogenesis [4]. Changes in hormones balance and expression may promote the immunological imbalance and skin function responsible for urticaria expression.…”

Section: Introductionmentioning

confidence: 98%

Sex hormones and urticaria

Kasperska−Zając

Brzoza

Rogala

2008

Journal of Dermatological Science

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 98%

Sex hormones and urticaria

Kasperska−Zając

Brzoza

Rogala

2008

Journal of Dermatological Science

View full text Add to dashboard Cite

“…Moreover, it is known that, abnormalities in sex hormone metabolism and/or secretion may modulate activity of some immunologic and inflammatory diseases [30]. It has been suggested that dysfunction of the neuro-endocrine-immune environment may have a role in some cases of chronic urticaria [31]. Interestingly, we observed that serum DHEA-S concentration may be lower in chronic urticaria patients, regardless their gender and response to autologous serum skin test, as compared with sex-and age-matched healthy controls [32][33][34][35].…”

Section: Introductionmentioning

confidence: 99%

Dehydroepiandrosterone and Dehydroepiandrosterone Sulphate in Atopic Allergy and Chronic Urticaria

2008

View full text Add to dashboard Cite

The increasing amounts of evidence prove that sex hormones modulate different cells function, including mast cells and lymphocytes. Dehydroepiandrosterone (DHEA) and its sulphate ester (DHEA-S) are both the secretory products of adrenal glands and the most abundant hormones in the systemic circulation of humans, converted then into androgens and estrogens in the periphery. DHEA may affect production of Th1 and Th2- associated cytokines, suggesting their significance in diseases where imbalanced lymphocyte activity plays the essential role, also in atopic diseases. Reduced circulating concentration of these androgens has been demonstrated in patients with immune-inflammatory diseases, including atopic eczema/dermatitis syndrome and asthma. It is unknown however, whether such changes contribute in any way to etiopathogenesis of the disorders, or are merely their consequences. Chronic urticaria, not included in the atopic triad, is a mast cell-dependent disease characterised by activation of autoimmune and inflammatory processes responding to different factors. Alterations in the immune-neuro-endocrine milieu may contribute to the development of the disease. It has been demonstrated that DHEA-S concentration is significantly lower in the peripheral circulation of patients suffering from chronic urticaria, as compared with healthy subjects. On one hand, this reflects some changes in hormonal homeostasis in the course of urticarial processes, yet on the other, suggests some possible role for this hormone in pathophysiology of the disease. In this brief review we present the available data on DHEA-S involvement in events associated with atopic allergy as well as chronic urticaria.

show abstract

“…On one hand, hormones regulate the immune and inflammatory response, on the other hand, the inflammatory mediators influence the hormonal balance [5]. Interestingly, dysfunctions of the neuroendocrine–immune system due to stress and other factors seem to appear as a very interesting theory for urticaria pathogenesis [6]. It is known that urticaria may be associated with some diseases and/or influenced by some conditions characterized by sex hormonal changes, including menstrual cycle, pregnancy, menopause, and hormonal contraceptives or hormone replacement therapy.…”

Section: Introductionmentioning

confidence: 99%

Does Dehydroepiandrosterone Influence the Expression of Urticaria?—a Mini Review

Kasperska−Zając

2010

Inflammation

View full text Add to dashboard Cite

Chronic urticaria is a challenging problem since the exact cause and mechanism involved in the disease development have still remained unknown. This disease is associated with mast cells activation and immunoinflammatory processes. Interestingly, dysfunctions of the neuroendocrine–immune system due to stress and other factors seem to appear as a very interesting theory for urticaria pathogenesis. Dehydroepiandrosterone and its sulfate derivative (DHEA-S) appear to have regulatory effects in immune homeostasis and are regulated by the nervous system, and it is suggested that they may be an integral element of neuroimmunomodulation. Our studies showed substantially decreased serum concentration of DHEA-S in patients with chronic urticaria. However, current knowledge prevents answering whether lower circulating DHEA-S concentration is a primary phenomenon or just an accompanying one which appears as a response of different systems to the course of the illness and may not be of any importance for the pathogenesis of urticaria whatsoever. This review is a summary of clinical research on the role of DHEA in chronic urticaria.

show abstract

Angioedema and systemic sclerosis

Cited by 4 publications

References 0 publications

Sex hormones and urticaria

Sex hormones and urticaria

Dehydroepiandrosterone and Dehydroepiandrosterone Sulphate in Atopic Allergy and Chronic Urticaria

Does Dehydroepiandrosterone Influence the Expression of Urticaria?—a Mini Review

Contact Info

Product

Resources

About