Angio-oedema after fluconazole

Adverse drug reactions of the new oral antifungal agents – terbinafine, fluconazole, and itraconazole

“…44 Anaphylactic reaction with paresthesia has also been described. 45 Cutaneous side-effects Cutaneous adverse reactions are usually mild, and include pruritus and exanthems. Rarely, more severe skin reactions have been described: erythema multiforme, 46 including severe forms of the disease, Stevens-Johnson syndrome, 46 and toxic epidermal necrolysis.…”

“…Anaphylactic reaction induced by fluconazole has rarely been reported. 45,52 Endocrine side-effects Only minimal effects of human steroid synthesis have been found. [53][54][55] No significant effect of fluconazole on testosterone and cortisol synthesis 53,55 or testosterone serum levels 40 was found, but Gradon and Sepkowitz 56 described a case of acute adrenal insufficiency after 3 weeks of fluconazole therapy at a daily dose of 200 mg.…”

“…Rarely, more severe skin reactions have been described: erythema multiforme, 46 including severe forms of the disease, Stevens–Johnson syndrome, 46 and toxic epidermal necrolysis. 47 Isolated reports of exfoliative dermatitis, 48 fixed drug eruption, 49 angioedema with oral ulcers, 45 and purpura related to thrombocytopenia have also been described. Reversible alopecia was found in both men and women, usually during treatment with high doses (400 mg/day) of fluconazole.…”

Fluconazole-lnduced Toxic Epidermal Necrolysis in a Patient with Human Immunodeficiency Virus Infection

“…This drug is used in patients with AIDS to treat superficial and systemic infections with Candida spe cies and cryptococcosis [3]. Fluconazole is well tolerated, the most common clinical side effects being nausea and other minor gastrointestinal symptoms [3], Skin reactions due to fluconazole are very rare; they include rashes similar to that occurring with ß-lactam agents, with an estimated prevalence of 4% in some series [4] and cases of angioedcma [5]. Four cases of Stevens-Johnson syndrome during treatment with fluconazole have been reported [6,7]; how ever, it may not be related to fluconazole because other drugs were also given in 3 cases [7].…”