Aneurysmal Fibrous Histiocytoma: Clinicopathology Analysis of 30 Cases of a Rare Variant of Cutaneous Fibrohistiocytoma

Nabatanzi, Amelia; Male, Musa; Qu, Xiaolei; Li, Yanqiu; Xie, Mingxing; Di, Wu-Shi; Huang, Changzheng

doi:10.1007/s11596-019-2011-9

Cited by 9 publications

(10 citation statements)

References 15 publications

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“…Due to its atypical livid colouring, dolency and atypical fast growth, initial clinical diagnosis might pose a multitude of differential diagnoses. Common differential diagnoses include an angiomatoid fibrous histiocytoma, Kaposi sarcoma, malignant melanoma, atypical angiosarcoma or extraosseous bone sarcoma, such as an Ewing sarcoma [ 20 , 23 , 24 , 25 ]. A mere visual diagnosis is often not sufficient, and further histopathological and immunohistochemical testing is required.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Metastasising Aneurysmal Fibrous Histiocytoma: A Case Report, Literature Review and Proposal of Standardised Diagnostic Criteria

Mankertz,

Keßler,

Rau

et al. 2023

Diseases

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An aneurysmal fibrous histiocytoma is a rare cutaneous soft-tissue tumour which accounts for approximately 0.06% of all dermatopathologies. Metastasis is exceedingly uncommon, to the point that there have only been eight reported cases in the scientific literature. We present the case of a 25-year-old male with a primary aneurysmal fibrous histiocytoma located in the nuchal region which exhibited rapid growth and abrupt ulceration over a short time span and showed signs of locoregional aggressive infiltration. A subsequent histopathological analysis confirmed the presence of diffuse solid and cystic pulmonary metastases. Further genetic sequencing verified LAMTOR1-PRKCD fusion. This case report seeks to review the existing literature on aneurysmal fibrous histiocytoma, discuss the challenges of differential diagnosis and propose standardised diagnostic criteria.

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Section: Discussionmentioning

confidence: 99%

Pulmonary Metastasising Aneurysmal Fibrous Histiocytoma: A Case Report, Literature Review and Proposal of Standardised Diagnostic Criteria

Mankertz,

Keßler,

Rau

et al. 2023

Diseases

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“…Os aspectos da derme coincidem com o histicitoma fibroso aneurismal em humanos, que consiste na proliferação de múltiplos espaços vasculares com células pouco diferenciadas (Nabatanzi et al, 2019) já de acordo com a classificação veterinária se enquadra no histiocitoma fibroso, pela proliferação de células histiocíticas pleomórficas associada a fibroblastos, e presença de canais vasculares entremeando as células neoplásicas da derme (Meuten, 2016;Moore, 2014).…”

Section: Discussionunclassified

Histiocitoma fibroso maligno en el plano nasal de un perro: Reporte de caso

Santos¹,

Medeiros²,

Eloy³

et al. 2021

Pubvet

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Um cão, fêmea, poodle, 8 anos, apresentou queixa principal de lesão ulcerada em plano nasal e epixtase, com evolução de aproximadamente seis meses. O animal foi submetido a anestesia para retirada do nódulo de 0,5 cm de diâmetro. O material foi encaminhado para exame histopatológico de rotina com coloração de Hematoxilina-Eosina (HE) e respectivamente imuno-histoquímica. No exame histopatológico notou-se uma massa nodular, com bordos mal definidos, constituída por células arredondadas de citoplasma escasso e cromatina nuclear condensadas que iam desde a derme profunda e dissecavam parte da epiderme. Essas células apresentavam um padrão de pleomorfismo alto e alta relação núcleo:citoplasma. Entremeando o estroma observou-se grande quantidade de estruturas vasculares que vão desde a superfície basal até a derme superficial. O exame imuno-histoquímico revelou forte marcação para o complexo principal de histocompatibilidade MHCII, que cora fortemente linfócitos e histiócitos, que correspondem a estrutura tumoral e proliferativa das células neoplásicas do tumor. Os tumores histiocíticos, bem como histiocitomas são relativamente comuns em cães jovens e mais raramente os histiocitomas fibrosos malignos são diagnosticados em cães, ocorrendo mais comumente em humanos. Nesse relato são descritas as características patológicas e imuno-histoquímicas que permitiram o diagnóstico, possibilitando a diferenciação entre histiocitomas não fibróticos e outras neoplasias caninas comuns.

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“…The KDFs were much more likely to be accompanied by hemorrhage (77% vs 11%, P = 3 × 10 −27 ), which is a feature of the aneurysmal DF variant. 2 Since hemosiderin deposition and siderophage infiltration are usually found at the later stage of hemorrhage, the propensity of KDF to associate with hemorrhage explains why both features were much more common in KDFs as well (77% vs 11%, P = 1 × 10 −26 ). These features were observed inside or around the keloid-like area (Figure 1).…”

Section: Re Sultsmentioning

confidence: 99%

“…There is a wide variety of clinicopathological variants of DF, which can be problematic for differential diagnosis. They include aneurysmal DF, 2 lipidized DF, 3 atypical DF (or DF with monster cells), 4 myxoid DF, 5 atrophic DF, 6 DF with granular cells, 7 DF with clear cells, 8 cellular DF, 9 myofibroblastic DF, 10 sclerotic DF, 11 osteoclastic DF, 12 palisading DF, 13 epithelioid DF, 14 and keloidal DF (KDF) 15 . The latter is characterized by a circumscribed keloid‐like area composed of irregularly oriented, thick, and brightly eosinophilic keloidal collagen (KC) in the superficial portion of an otherwise typical DF.…”

Section: Introductionmentioning

confidence: 99%

Keloidal dermatofibroma: Clinicopathological comparison of 52 cases with a series of 2077 other dermatofibromas

Nishimoto

Ansai

Akaishi

et al. 2022

The Journal of Dermatology

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Dermatofibroma is a common benign skin lesion with a contested etiology: some believe it is a neoplasm while others propose minor injuries initiate it. Many dermatofibroma variants have been described, including keloidal dermatofibroma, which is unusual by bearing keloidal collagen. Keloidal dermatofibroma was first described in 1998 and only 15 cases have been reported. Since keloids are driven by skin injuries, the existence of keloidal dermatofibroma has been suggested to support the injury hypothesis of dermatofibroma etiology. To better understand keloidal dermatofibroma characteristics and gain clues regarding dermatofibroma etiology, consecutive keloidal dermatofibroma cases (n = 52) and dermatofibroma without keloidal collagen (n = 2077) that were histopathologically diagnosed in 2016–2019 were identified from the records of a Japanese dermatopathology laboratory and compared in terms of demographic, clinical, and histopathological characteristics by univariate analyses. Compared to other dermatofibromas, keloidal dermatofibromas occurred more frequently on the forearm and hand (P < 0.0001 and 0.0019), especially the wrist dorsum, and in the superficial skin layer (P < 0.0001). Keloidal dermatofibromas also demonstrated more cellularity and hemorrhage (both P < 0.0001). Correlation analyses between keloidal collagen amount and keloidal dermatofibroma size (a proxy of time‐since‐onset) did not support the notion that keloidal collagen deposition and keloidal dermatofibroma formation are triggered simultaneously. Recent injury, as indicated by fresh hemorrhage, was equally common in putatively older and younger keloidal dermatofibromas. Thus, keloidal collagen in keloidal dermatofibromas could be due to injury to preexisting dermatofibromas, which suggests that the keloidal dermatofibroma entity does not prove the injury hypothesis. Commonalities between keloids and keloidal dermatofibromas suggest a link between genetics, provocative events that induce myofibroblast differentiation, and keloidal collagen production.

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Aneurysmal Fibrous Histiocytoma: Clinicopathology Analysis of 30 Cases of a Rare Variant of Cutaneous Fibrohistiocytoma

Cited by 9 publications

References 15 publications

Pulmonary Metastasising Aneurysmal Fibrous Histiocytoma: A Case Report, Literature Review and Proposal of Standardised Diagnostic Criteria

Pulmonary Metastasising Aneurysmal Fibrous Histiocytoma: A Case Report, Literature Review and Proposal of Standardised Diagnostic Criteria

Histiocitoma fibroso maligno en el plano nasal de un perro: Reporte de caso

Keloidal dermatofibroma: Clinicopathological comparison of 52 cases with a series of 2077 other dermatofibromas

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