Aneurysmal Bone Cysts of Soft Tissue Represent True Neoplasms

Pietschmann, Matthias F.; Oliveira, André M.; Chou, Margaret M.; Ihrler, St.; Niederhagen, Manuel; Baur‐Melnyk, Andrea; Dürr, Hans Roland

doi:10.2106/jbjs.j.00534

Cited by 22 publications

(27 citation statements)

References 26 publications

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“…These lesions are benign, locally aggressive, and can recur locally [2]. ABCs can occur in any age group, but patients are generally in the first two decades of life [3].…”

Section: Introductionmentioning

confidence: 99%

“…ABCs can occur in any age group, but patients are generally in the first two decades of life [3]. There is no predisposition for either gender [2]. Complete surgical excision is often curative.…”

Section: Introductionmentioning

confidence: 99%

“…Aneurysmal bone cysts were initially thought to represent reactive processes of bone because of their occasional association with other benign or malignant neoplasms [2,4]. However, a primary form of ABC also exists, demonstrated by the discovery of translocations involving the ubiquitin-specific peptidase 6 (USP6) gene suggesting a clonal process [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

“…Soft-tissue ABCs are much rarer than their intraosseous counterparts, with fewer than 25 cases documented in the literature [2,6,[9][10][11][12][13][14][15][16]. Of these, only two have been characterized by cytogenetic analysis.…”

Section: Introductionmentioning

confidence: 99%

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Soft-tissue aneurysmal bone cyst with translocation t(17;17)(p13;q21) corresponding to COL1A1 and USP6 loci

Jacquot

Szymańska

Nemana³

et al. 2015

Skeletal Radiol

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We present the case of a 46-year-old woman with no significant past medical history who developed left mid-thigh pain and fullness. Imaging demonstrated a mineralized soft-tissue mass, which increased in size during a year of monitoring, but retained a circumscribed appearance. The mass was located in the medial soft tissues of the thigh, separate from the bone on imaging studies, and this finding was confirmed during excision. The mass showed gross and microscopic features of an aneurysmal bone cyst. This diagnosis was supported by cytogenetic analysis revealing a t(17;17)(p13;q21) translocation corresponding to the USP6 and COL1A1 loci. Soft-tissue aneurysmal bone cyst is a rare entity, with fewer than 25 reports in the literature. Limited cytogenetic information about these tumors is available. To our knowledge, the USP6 and COL1A1 rearrangement has only previously been described in a pediatric soft-tissue aneurysmal bone cyst. We also discuss the differential diagnosis of ossifying soft-tissue lesions.

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“…These lesions are benign, locally aggressive, and can recur locally [2]. ABCs can occur in any age group, but patients are generally in the first two decades of life [3].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Soft-tissue aneurysmal bone cyst with translocation t(17;17)(p13;q21) corresponding to COL1A1 and USP6 loci

Jacquot

Szymańska

Nemana³

et al. 2015

Skeletal Radiol

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“…Previously, ABC was believed to occur exclusively in bone (3), but in recent years a few cases of soft tissue ABC (STABC) have been reported (1,(4)(5)(6)(7). STABC is a recently recognized extremely rare tumor with fewer than 20 welldocumented cases in the literature (7), as shown in Table I.…”

Section: Introductionmentioning

confidence: 99%

Soft tissue aneurysmal bone cyst in a 10-year-old girl

et al. 2011

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Abstract. We report the case of a 10-year-old girl with a soft tissue aneurysmal bone cyst (STABC) located in the posterior aspect of the left shoulder. Conventional radiography revealed an oblong mass with a calcified rim. On the computed tomography scan, the lesion appeared to have a non-uniform intralesional density with an incomplete rim. Magnetic resonance imaging revealed a multi-cavity lesion with fluid-fluid levels. Following pathological examination, the lesion was diagnosed as a STABC. This may be only the twentieth reported case in the English literature of this extremely rare benign tumor occurring in soft tissue. Eight months after surgery the patient was assessed at our outpatient clinic and found to have excellent mobility of her left shoulder and no sign of recurrence.

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