Anemia and COVID‐19: A prospective perspective

Benoit, Justin L.; Benoit, Stefanie; Oliveira, Maria Helena Santos de; Lippi, Giuseppe; Henry, Brandon Michael

doi:10.1002/jmv.26530

Cited by 17 publications

(15 citation statements)

References 9 publications

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“…Nutritional deficiencies are common among severe and fatal COVID-19, especially elderly adults and patients with age-related comorbidities such as diabetes and cardiovascular disorders [ 2 , 5 , 6 , 24 ]. Hypovitaminosis D [ 5 , 23 ], anemia [ 2 , 6 , 25 , 26 , 27 ], iron metabolism dysfunction [ 2 , 6 ], selenium deficiency [ 22 , 23 ], and hypoproteinemia [ 24 , 28 ] are associated with increased levels of proinflammatory cytokines, disease severity, increased admission to the hospital/intensive care unit (ICU), need for mechanical ventilation, and death among COVID-19 patients.…”

Section: Overviewmentioning

confidence: 99%

Approaches to Nutritional Screening in Patients with Coronavirus Disease 2019 (COVID-19)

Ali

Kunugi

2021

IJERPH

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Malnutrition is common among severe patients with coronavirus disease 2019 (COVID-19), mainly elderly adults and patients with comorbidities. It is also associated with atypical presentation of the disease. Despite the possible contribution of malnutrition to the acquisition and severity of COVID-19, it is not clear which nutritional screening measures may best diagnose malnutrition in these patients at early stages. This is of crucial importance given the urgency and rapid progression of the disease in vulnerable groups. Accordingly, this review examines the available literature for different nutritional screening approaches implemented among COVID-19 patients, with a special focus on elderly adults. After a literature search, we selected and scrutinized 14 studies assessing malnutrition among COVID-19 patients. The Nutrition Risk Screening 2002 (NRS-2002) has demonstrated superior sensitivity to other traditional screening measures. The controlling nutritional status (CONUT) score, which comprises serum albumin level, cholesterol level, and lymphocytes count, as well as a combined CONUT-lactate dehydrogenase-C-reactive protein score expressed a predictive capacity even superior to that of NRS-2002 (0.81% and 0.92% vs. 0.79%) in midlife and elder COVID-19 patients. Therefore, simple measures based on routinely conducted laboratory investigations such as the CONUT score may be timely, cheap, and valuable alternatives for identifying COVID-19 patients with high nutritional risk. Mini Nutritional Assessment (MNA) was the only measure used to detect residual malnutrition and high malnutrition risk in remitting patients—MNA scores correlated with hypoalbuminemia, hypercytokinemia, and weight loss. Older males with severe inflammation, gastrointestinal symptoms, and pre-existing comorbidities (diabetes, obesity, or hypertension) are more prone to malnutrition and subsequently poor COVID-19 prognosis both during the acute phase and during convalescence. Thus, they are in need of frequent nutritional monitoring and support while detecting and treating malnutrition in the general public might be necessary to increase resilience against COVID-19.

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Section: Overviewmentioning

confidence: 99%

Approaches to Nutritional Screening in Patients with Coronavirus Disease 2019 (COVID-19)

Ali

Kunugi

2021

IJERPH

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“…Among the severe COVID-19 patients studied by Benoit, the probability of anemia can reach 43.8%, of which mild anemia (110–119g/L) accounts for 18.8%, and moderate anemia (80–109g/L) accounts for 18.8%, severe anemia (<80g/L) accounted for 6.3%, each of which was higher than that of non-severe patients, and there is no severe anemia occurred in non-severe patients. 84 In addition, Lazarian reported that 7 cases of COVID-19 patients developed autoimmune hemolytic anemia (AIHA) during the course of their illness, with an average hemoglobin about 70g/L, and in severe cases, the hemoglobin level decreased by more than 30g/L. 85 Taherifard et al 86 also summarized 94 patients with COVID-19 complicated by autoimmune diseases, of which 22 (22/94) COVID-19 patients were complicated by AIHA, and the maximum hemoglobin decline reached 70g/L, which may be related to the autoimmune function of COVID-19 patients.…”

Section: Covid-19 and Red Blood Cellsmentioning

confidence: 99%

SARS-CoV-2 Infection: Differences in Hematological Parameters Between Adults and Children

Liu¹,

She²,

Bai³

et al. 2021

IJGM

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Since December 2019, corona virus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic, posing a huge threat to human health, and the current epidemic prevention situation is still severe. Hematological parameters directly reflect the damage of SARS-CoV-2 to human blood cells, which can better assess the severity and prognosis of patients infected with COVID-19, but hematological parameters have some differences between adults and children. This article comprehensively reviews the differences in hematological parameters between adults and children after SARS-CoV-2 infection, and provides a reference for the diagnosis and treatment of COVID-19.

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“…This prevalence is variable depending on the population and country studied. Benoit JL et al reported 34.7% of COVID-19 patients were diagnosed as having anemia at emergency department presentation in USA [8]. However, Dinevari MF et al evaluated 1274 COVID-19 patients who were hospitalized in İran and out of whom 615 (48.27%) were anemic and concluded that this higher prevalence may be related to higher prevalence of pre-existing anemia in İran and higher percentage of the female patients in their study [9].…”

Section: Discussionmentioning

confidence: 98%

COVID-19’da hangi anemi mortaliteyle ilişkili? Hafif, orta, ciddi?

Tezcan¹,

Çiftçi

2021

Turkish Journal of Clinics and Laboratory

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Aim:We aimed to investigate the prevalence of anemia at admission to intensive care unit (ICU), association between anemia and mortality, lengths of stay in hospital and ICU (LOS-H and LOS-ICU) in COVID-19 patients. Material and Methods:We retrospectively analyzed the data of 288 COVID-19 patients who needed ICU admission.Patients were divided into two groups: anemic and nonanemic. Demographic data, labaratory findings at ICU admission, LOS-H and LOS-ICU, mortality were compared between groups. A further classification was made based on hemoglobin levels; severe, moderate and mild anemic patients were analyzed. LOS-H, LOS-ICU and mortality were compared between patients with hemoglobin > 109 g/L and ≤ 109 g/L. Thus; moderate and severe anemic patients were compared to mild anemic and nonanemic patients.Results: Anemia was detected in 137 (47.6%) patients upon admission to the ICU. Of those; 54 patients (39.4%) had mild, 76 patients (55.5%) had moderate, 7 patients (5.1%) had severe anemia. Anemic patients were older, had multiple comorbidities, lower hemoglobin and albumin, higher red cell distribution width (RDW), creatinine and procalcitonin levels. While LOS-H, LOS-ICU and mortality rates did not significantly differ between anemic and nonanemic patients; mortality rate was significantly high in patients with hemoglobin levels ≤ 109 g/L (moderate anemic) compared to patients with a hemoglobin level > 109 g/L (mild anemic and nonanemic). LOS-H and LOS-ICU were not significantly different between these patient groups. Only seven patients had severe anemia and all of these died. Conclusion:The results of this retrospective study showed that the anemia prevalence in ICU patients with COVID-19 was high, and mild anemia was not associated with higher mortality rates, while moderate and severe anemia were. Hemoglobin levels of anemic patients with COVID-19 should be closely monitored for timely detecting signs of disease progression.

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Anemia and COVID‐19: A prospective perspective

Cited by 17 publications

References 9 publications

Approaches to Nutritional Screening in Patients with Coronavirus Disease 2019 (COVID-19)

Approaches to Nutritional Screening in Patients with Coronavirus Disease 2019 (COVID-19)

SARS-CoV-2 Infection: Differences in Hematological Parameters Between Adults and Children

COVID-19’da hangi anemi mortaliteyle ilişkili? Hafif, orta, ciddi?

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