Andrographolide suppresses melanin synthesis through Akt/GSK3β/β-catenin signal pathway

Zhu, Ping; Yin, Wei-Han; Wang, Mengran; Dang, Yongyan; Ye, Xiyun

doi:10.1016/j.jdermsci.2015.03.013

Cited by 51 publications

(48 citation statements)

References 33 publications

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“…In recent years, many researchers have attempted to identify effective and safe anti-melanogenesis ingredients [44]. Melatonin [45,46], 4-hydroxy-3-methoxycinnamaldehyde (4H3MC) [47], hesperidin [48], and andrographolide [49] were found to inhibit melanogenesis in B16F10 melanoma cells, as well as in human melanocytes. However, there are several controversies, regarding the effect of quercetin (3,3,4,5,7-pentahydrosyflavone), based on in vitro and human trials.…”

Section: Discussionmentioning

confidence: 99%

Effects of Ganodermanondiol, a New Melanogenesis Inhibitor from the Medicinal Mushroom Ganoderma lucidum

Kim

et al. 2016

IJMS

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Ganoderma lucidum, a species of the Basidiomycetes class, has been attracting international attention owing to its wide variety of biological activities and great potential as an ingredient in skin care cosmetics including “skin-whitening” products. However, there is little information available on its inhibitory effect against tyrosinase activity. Therefore, the objectives of this study were to investigate the chemical composition of G. lucidum and its inhibitory effects on melanogenesis. We isolated the active compound from G. lucidum using ethanol extraction and ethyl acetate fractionation. In addition, we assayed its inhibitory effects on tyrosinase activity and melanin biosynthesis in B16F10 melanoma cells. In this study, we identified a bioactive compound, ganodermanondiol, which inhibits the activity and expression of cellular tyrosinase and the expression of tyrosinase-related protein-1 (TRP-1), TRP-2, and microphthalmia-associated transcription factor (MITF), thereby decreasing melanin production. Furthermore, ganodermanondiol also affected the mitogen-activated protein kinase (MAPK) cascade and cyclic adenosine monophosphate (cAMP)-dependent signaling pathway, which are involved in the melanogenesis of B16F10 melanoma cells. The finding that ganodermanondiol from G. lucidum exerts an inhibitory effect on tyrosinase will contribute to the use of this mushroom in the preparation of skin care products in the future.

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Section: Discussionmentioning

confidence: 99%

Effects of Ganodermanondiol, a New Melanogenesis Inhibitor from the Medicinal Mushroom Ganoderma lucidum

Kim

et al. 2016

IJMS

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“…150 Identification of new or improved combination of ingredients with a defined mechanism and therapeutic profiles would also be based on the detailed structure-activity relationship studies. Although many of these applications have inhibitory activity against melanogenesis, very few became a commercial product based on cytotoxicity, cutaneous absorption and clinical trials [151][152][153][154][155][156][157] (Table 3).…”

Section: Current Approaches and Ingredients For Skin Brightening And mentioning

confidence: 99%

<p>Melanogenic Difference Consideration in Ethnic Skin Type: A Balance Approach Between Skin Brightening Applications and Beneficial Sun Exposure</p>

Markiewicz¹,

Idowu²

2020

CCID

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Human skin demonstrates a striking variation in tone and color that is evident among multiple demographic populations. Such characteristics are determined predominantly by the expression of the genes controlling the quantity and quality of melanin, which can alter significantly due to the presence of small nucleotide polymorphism affecting various steps of the melanogenesis process and generally linked to the lighter skin phenotypes. Genetically determined, constitutive skin color is additionally complemented by the facultative melanogenesis and tanning responses; with high levels of melanin and melanogenic factors broadly recognized to have a protective effect against the UVR-induced molecular damage in darker skin. Long-term sun exposure, together with a genetic makeup responsible for the ability to tan or the activity of constitutive melanogenic factors, triggers defects in pigmentation across all ethnic skin types. However, sun exposure also has well documented beneficial effects that manifest at both skin homeostasis and the systemic level, such as synthesis of vitamin D, which is thought to be less efficient in the presence of high levels of melanin or potentially linked to the polymorphism in the genes responsible for skin darkening triggered by UVR. In this review, we discuss melanogenesis in a context of constitutive pigmentation, defined by gene polymorphism in ethnic skin types, and facultative pigmentation that is not only associated with the capacity to protect the skin against photo-damage but could also have an impact on vitamin D synthesis through gene polymorphism. Modulating the activities of melanogenic genes, with the focus on the markers specifically altered by polymorphism combined with differential requirements of sun exposure in ethnic skin types, could enhance the applications of already existing skin brightening factors and provide a novel approach toward improved skin tone and health in personalized skincare.

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“…This compound targets NF-κB both by reducing its gene expression and reducing its DNA binding activity to p65 [41]. Moreover, it also suppresses melanin synthesis through the Akt/GSK3β/β-catenin signal pathway [42] and inhibits melanoma tumour growth by inactivating the TLR4/NF-κB signalling pathway [43].…”

Section: Labdanesmentioning

confidence: 99%

Natural Cytotoxic Diterpenoids, a Potential Source of Drug Leads for Melanoma Therapy

Prieto

Silveira

2019

CPD

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Diterpenes present complex structure and due to their unique carbon skeleton and interesting biological activities, have been the focus of continuous studies for the development of new anticancer agents. Phorbol esters have been known for their activity against skin malignancies since ancient times. Taxol was first studied in melanoma cells, and recently ingenol mebutate has been approved for the chemoprevention of melanoma in actinic keratosis patients. Therefore, there is scope for research on this class of compounds. We here aim to review the relevant original research reporting on isolated diterpenes with cytotoxic and/or antitumoral activities upon melanoma cells. By collating and discussing the implications of past and current developments on diterpenes, we hope to steer further interest on this field and facilitate the drug discovery activities of the scientific community towards finding potential alternatives to current melanoma chemotherapy.

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Andrographolide suppresses melanin synthesis through Akt/GSK3β/β-catenin signal pathway

Cited by 51 publications

References 33 publications

Effects of Ganodermanondiol, a New Melanogenesis Inhibitor from the Medicinal Mushroom Ganoderma lucidum

Effects of Ganodermanondiol, a New Melanogenesis Inhibitor from the Medicinal Mushroom Ganoderma lucidum

<p>Melanogenic Difference Consideration in Ethnic Skin Type: A Balance Approach Between Skin Brightening Applications and Beneficial Sun Exposure</p>

Natural Cytotoxic Diterpenoids, a Potential Source of Drug Leads for Melanoma Therapy

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