Andrographolide inhibits NF-κB activation and attenuates neointimal hyperplasia in arterial restenosis

Wang, Yu Jiu; Wang, Liangjing; Fan, Quan Xin; Geng, Jian Guo

doi:10.1038/cr.2007.89

Cited by 72 publications

(60 citation statements)

References 30 publications

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“…grapholide are associated with preventing NF-B. It has been confirmed that Andrographolide covalently modifies the reduced cysteine 62 of p50-a major subunit of NF-B transcription factors, thus blocking the binding of NF-B transcription factors to the promoters of their target genes, preventing NF-B activation and inhibiting inflammation in vitro and in vivo (9). NF-B plays a central role in asthma.…”

Section: Discussionmentioning

confidence: 89%

Inhibition of NF-κB Expression and Allergen-induced Airway Inflammation in a Mouse Allergic Asthma Model by Andrographolide

Luo

Wang

et al. 2009

Cell Mol Immunol

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Section: Discussionmentioning

confidence: 89%

Inhibition of NF-κB Expression and Allergen-induced Airway Inflammation in a Mouse Allergic Asthma Model by Andrographolide

Luo

Wang

et al. 2009

Cell Mol Immunol

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“…A number of studies have demonstrated that andrographolide and its analogues possess potential anti-inflammatory and antitumor effects mediated by attenuation of nuclear factor-κB activation in various systems (11)(12)(13)(14). Andrographolide also induces cell cycle arrest and apoptosis of cancer cells by inhibiting phosphoinositide 3-kinase/protein kinase B, mitogen-activated protein kinase and other tumor growth pathways, depending on the type of treated cells (15)(16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

“…The diterpenoid lactone andrographolide is one of the biologically active constituents of Andrographis paniculata, a medicinal plant traditionally used for prevention and treatment of various diseases (11)(12)(13). A number of studies have demonstrated that andrographolide and its analogues possess potential anti-inflammatory and antitumor effects mediated by attenuation of nuclear factor-κB activation in various systems (11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

Andrographolide induces apoptotic and non-apoptotic death and enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in gastric cancer cells

et al. 2017

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Abstract. Andrographolide, a natural compound isolated from Andrographis paniculata, has been reported to possess antitumor activity. In the present study, the effect of andrographolide in human gastric cancer (GC) cells was investigated. Andrographolide induced cell death with apoptotic and non-apoptotic features. At a low concentration, andrographolide potentiated apoptosis and reduction of clonogenicity triggered by recombinant human tumor necrosis factor-related apoptosis-inducing ligand (rhTRAIL). Exposure of GC cells to andrographolide altered the expression level of several growth-inhibiting and apoptosis-regulating proteins, including death receptors. It was demonstrated that activity of the TRAIL-R2 (DR5) pathway was critical in the development of andrographolide-mediated rhTRAIL sensitization, since its inhibition significantly reduced the extent of apoptosis induced by the combination of rhTRAIL and andrographolide. In addition, andrographolide increased reactive oxygen species (ROS) generation in a dose-dependent manner. N-acetyl cysteine prevented andrographolide-mediated DR5 induction and the apoptotic effect induced by the combination of rhTRAIL and andrographolide. Collectively, the present study demonstrated that andrographolide enhances TRAIL-induced apoptosis through induction of DR5 expression. This effect appears to involve ROS generation in GCs.

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“…Plant extract andrographolide blocks the binding of NF-KB transcription factor to the promoter regions of target genes, prevents NF-KB activation and inhibits inflammation. Interestingly it has been reported that andrographolide attenuates neointimal hyperplasia in a murine model of restenosis (21).…”

Section: Discussionmentioning

confidence: 99%

An important role for VCAM-1, but not for ICAM-1 in restenosis following coronary stent implantation

Bayata¹,

Arıkan²,

Yeşìl³

et al. 2010

Anadolu Kardiyol Derg

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Amaç: Bu çalışmada stabil koroner arter hastalığı nedeni ile stent implante edilen olgularda, adezyon moleküllerinin seviyesi ile restenoz arasındaki ilişki araştırılmıştır. Yöntemler: Stabil angina pectoris nedeni ile proksimal sol ön inen artere stent implante edilen 15 olguda işlem öncesi ve sonrasında dolaşım-daki hücreler arası adezyon molekül-1 (ICAM-1) ve vasküler hücre adezyon molekül -1 (VCAM-1) seviyeleri prospektif gözlemsel olarak araştı-rılmıştır. Hastalarda çıplak metal stent kullanılmıştır. Tüm hastalara restenoz değerlendirmesi amacı ile tespiti için implantasyonun 6. ayında tekrar koroner anjiyografi yapıldı. Çalışma sonunda restenoz saptanan ve saptanmayan hastalara ait sürekli değişkenler Mann-Whitney U testi ile karşılaştırıldı. Tekrarlanan ölçümlere ait sürekli değişkenlerin karşılaştırılmasında Wilcoxon T testi kullanıldı. Kategorik veriler ise Ki-kare testi ile karşılaştırıldı. Bulgular: Perkütan koroner girişim (PKG) öncesi bazal ICAM-1 ve VCAM-1 konsantrasyonları sırası ile 4.89±2.28 ve 46.35±22.96 ng/ml bulunmuş-tur. Ölçülen ICAM-1 ve VCAM-1 seviyeleri PKG' den 24 saat sonra istatistik olarak anlamsız derecede artış göstermiştir (5.01±2.35ng/ml ve 52.57±19.40 ng/ml). Altı olguda (%40) 6. ayda restenoz tespit edilmiştir. Restenoz gelişen ve gelişmeyen hasta grupları arasında ortalama stent uzunluğu, çapı ve balon şişme basıncı bakımından fark bulunmamıştır. Stent implantasyonundan önce ve sonra ölçülen VCAM değerleri restenoz olmayan grupta anlamlı değişiklik göstermemiş, bununla birlikte restenoz grubunda anlamlı artış göstermiştir (45.1±21.0' den 57.2±14.3 ng/ml'ye, p<0.05). Bazal ve post PKG ICAM-1 değerleri restenoz olan ve olmayan gruplarda anlamlı değişiklik göstermemiştir. Sonuç: Bu sonuçlar koroner stent implantasyonunu takip eden restenozda adezyon moleküllerinden ICAM-1'e göre VCAM-1'in daha önemli rolü olduğunu düşündürmektedir. (Anadolu Kardiyol Derg 2010; 10: 405-9) Anahtar kelimeler: Restenoz, stent, inflamasyon, vasküler hücre adezyon molekül -1, hücreler arası adezyon molekül-1 ÖZET Objective: In this study, we evaluated the possibility that, levels of circulating adhesion molecules following direct stent implantation may be a marker of restenosis. Methods: This prospective, observational study investigated levels of circulating intercellular (ICAM-1), and vascular cell (VCAM-1) adhesion molecules in 15 patients with stable angina pectoris before and after coronary stent implantation for single vessel-single lesion disease in proximal left anterior descending artery. All patients received bare-metal stents. Patients underwent repeat coronary angiography for detection of restenosis at 6 month. Continuous data between patients with and without restenosis were compared using Mann-Whitney U test. Repeated measurements were compared using Wilcoxon T test. Categorical data were compared using Chi-square statistics. Results: Baseline ICAM-1 and VCAM-1 concentrations before percutaneous coronary intervention (PCI) were 4.89±2.28 and 46.35±22.96 ng/ml respectively. Levels of ICAM ...

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Andrographolide inhibits NF-κB activation and attenuates neointimal hyperplasia in arterial restenosis

Cited by 72 publications

References 30 publications

Inhibition of NF-κB Expression and Allergen-induced Airway Inflammation in a Mouse Allergic Asthma Model by Andrographolide

Inhibition of NF-κB Expression and Allergen-induced Airway Inflammation in a Mouse Allergic Asthma Model by Andrographolide

Andrographolide induces apoptotic and non-apoptotic death and enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in gastric cancer cells

An important role for VCAM-1, but not for ICAM-1 in restenosis following coronary stent implantation

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