Andrographolide as an Anti-H1N1 drug and the mechanism related to retinoic acid-inducible gene-I-like receptors signaling pathway

Yu, Bin; Dai, Congqi; Jiang, Zhuhua; En-qing, LI; Chen, Chen; Wu, Xiaoyi; Chen, Jia; Liu, Qian; Zhao, Changlin; He, Jin-xiong; Ju, Dianwen; Chen, Xiaoyin

doi:10.1007/s11655-014-1860-0

Cited by 54 publications

(34 citation statements)

References 21 publications

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“…These observations were consistent with a previous study, which showed that sesamin downregulated p38 and JNK MAPK signaling pathways via IL-1β-induced human articular chondrocytes (Phitak et al 2012). Moreover, a recent report has shown that andrographolide inhibited the H1N1-infected cell model, while using the H1N1-infected respiratory epithelial cells and coculturing with the immunological cells including the dendritic cells, macrophage, and monocytes, via the RIG-I-like receptor signaling pathway (Yu et al 2014). Thus, it may be that sesamin can inhibit H1N1-induced PBMCs not only though MAPK inhibition but also via other signaling cascades, which should be further investigated.…”

Section: Discussionsupporting

confidence: 92%

Effect of sesamin against cytokine production from influenza type A H1N1-induced peripheral blood mononuclear cells: computational and experimental studies

Fanhchaksai

Kodchakorn

Pothacharoen

et al. 2015

In Vitro Cell.Dev.Biol.-Animal

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In 2009, swine flu (H1N1) had spread significantly to levels that threatened pandemic influenza. There have been many treatments that have arisen for patients since the WHO first reported the disease. Although some progress in controlling influenza has taken place during the last few years, the disease is not yet under control. The development of new and less expensive anti-influenza drugs is still needed. Here, we show that sesamin from the seeds of the Thai medicinal plant Sesamum indicum has anti-inflammatory cytokines in human peripheral blood mononuclear cells (PBMCs) induced by 2009 influenza virus type A H1N1. In this study, the combinatorial screening method combined with the computational approach was applied to investigate the new molecular binding structures of sesamin against the 2009 influenza virus type A H1N1 (p09N1) crystallized structure. Experimental methods were applied to propose the mechanisms of sesamin against cytokine production from H1N1-induced human PBMC model. The molecular dynamics simulation of sesamin binding with the p09N1 crystallized structure showed new molecular binding structures at ARG118, ILE222, ARG224, and TYR406, and it has been proposed that sesamin could potentially be used to produce anti-H1N1 compounds. Furthermore, the mechanisms of sesamin against cytokine production from influenza type A H1N1-induced PBMCs by ELISA and signaling transduction showed that sesamin exhibits the ability to inhibit proinflammatory cytokines, IL-1β and TNF-α, and to enhance the activity of the immune cell cytokine IL-2 via downregulating the phosphorylated JNK, p38, and ERK1/2 MAPK signaling pathways. This information might very well be useful in the prevention and treatment of immune-induced inflammatory disorders.

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Section: Discussionsupporting

confidence: 92%

Effect of sesamin against cytokine production from influenza type A H1N1-induced peripheral blood mononuclear cells: computational and experimental studies

Fanhchaksai

Kodchakorn

Pothacharoen

et al. 2015

In Vitro Cell.Dev.Biol.-Animal

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“…Andrographolide is well known for its anti-inflammatory effects under various conditions such as cancer and malaria, its antiviral action against infections of the upper respiratory tract and intestinal tract, and its immunomodulatory effects whereby it enhances the expression of cytotoxic T cells and natural killer cells and promotes phagocytosis and antibody-dependent cellmediated cytotoxicity [27][28][29][30][31].…”

Section: Discussionmentioning

confidence: 99%

Comparative effectiveness and safety of xiyanping with ribavirin for rotavirus enteritis therapy in childhood: A systematic review and meta-analysis

Jia¹,

Wang²,

Liu³

et al. 2018

Trop. J. Pharm Res

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“…The results suggest that andrographolide exerts its activity at a post entry step, and effectively inhibits viral genome replication. Several previous studies have shown that andrographolide possesses anti-cancer 30 31 , anti-metastasis 32 , anti-inflammatory 33 , anti-bacterial 34 and antiviral 35 36 37 38 39 40 41 42 43 activities. Andrographolide has been shown to exert activity on a wide range of viruses including human papillomavirus pseudovirus 38 , Influenza A virus 37 43 , hepatitis B virus 36 hepatitis C virus 39 , herpes simplex virus 41 42 and human immunodeficiency virus 35 40 .…”

Section: Discussionmentioning

confidence: 99%

“…The mechanism by which andrographolide exerts its anti-viral activity remains unknown, although retinoic acid inducible gene-1 (RIG-1)-like receptors 43 and the p38 MAPK/Nrf2 pathway 39 have been proposed as possible targets for the antiviral activity against Influenza A and hepatitis C viruses respectively. However, several studies have proposed that andrographolide exerts anti-cancer activity through an effect on TLR4/NF-kB 31 44 45 46 , and a recent proteomic analysis identified NF-kB as a specific andrographolide binding target 47 .…”

Section: Discussionmentioning

confidence: 99%

Activity of andrographolide against chikungunya virus infection

Wintachai

Kaur

Lee

et al. 2015

Sci Rep

120

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Chikungunya virus (CHIKV) is a re-emerging mosquito-borne alphavirus that has recently engendered large epidemics around the world. There is no specific antiviral for treatment of patients infected with CHIKV, and development of compounds with significant anti-CHIKV activity that can be further developed to a practical therapy is urgently required. Andrographolide is derived from Andrographis paniculata, a herb traditionally used to treat a number of conditions including infections. This study sought to determine the potential of andrographolide as an inhibitor of CHIKV infection. Andrographolide showed good inhibition of CHIKV infection and reduced virus production by approximately 3log10 with a 50% effective concentration (EC50) of 77 μM without cytotoxicity. Time-of-addition and RNA transfection studies showed that andrographolide affected CHIKV replication and the activity of andrographolide was shown to be cell type independent. This study suggests that andrographolide has the potential to be developed further as an anti-CHIKV therapeutic agent.

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Andrographolide as an Anti-H1N1 drug and the mechanism related to retinoic acid-inducible gene-I-like receptors signaling pathway

Cited by 54 publications

References 21 publications

Effect of sesamin against cytokine production from influenza type A H1N1-induced peripheral blood mononuclear cells: computational and experimental studies

Effect of sesamin against cytokine production from influenza type A H1N1-induced peripheral blood mononuclear cells: computational and experimental studies

Comparative effectiveness and safety of xiyanping with ribavirin for rotavirus enteritis therapy in childhood: A systematic review and meta-analysis

Activity of andrographolide against chikungunya virus infection

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