Andrographis paniculata and Its Bioactive Diterpenoids Against Inflammation and Oxidative Stress in Keratinocytes

Mussard, Eugenie; Jousselin, Sundy; Césaro, Annabelle; Legrain, Brigitte; Lespessailles, Éric; Estève, É.; Berteina‐Raboin, Sabine; Toumi, Hechmi

doi:10.3390/antiox9060530

Cited by 25 publications

(30 citation statements)

References 33 publications

(46 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Many researchers have reported the biomedical applications of herbal medicines [ 346 , 347 , 348 , 349 , 350 , 351 , 352 , 353 , 354 , 355 , 356 , 357 , 358 , 359 , 360 , 361 , 362 , 363 , 364 , 365 ]. Antibiotics and other chemical antimicrobial agents including metal oxide and metal nanoparticles can inhibit bacteria growth but also lead to ROS generation and other side effects.…”

Section: Conclusion and The Future Outlookmentioning

confidence: 99%

Antioxidant, Antimicrobial and Antiviral Properties of Herbal Materials

et al. 2020

View full text Add to dashboard Cite

Recently, increasing public concern about hygiene has been driving many studies to investigate antimicrobial and antiviral agents. However, the use of any antimicrobial agents must be limited due to their possible toxic or harmful effects. In recent years, due to previous antibiotics’ lesser side effects, the use of herbal materials instead of synthetic or chemical drugs is increasing. Herbal materials are found in medicines. Herbs can be used in the form of plant extracts or as their active components. Furthermore, most of the world’s populations used herbal materials due to their strong antimicrobial properties and primary healthcare benefits. For example, herbs are an excellent material to replace nanosilver as an antibiotic and antiviral agent. The use of nanosilver involves an ROS-mediated mechanism that might lead to oxidative stress-related cancer, cytotoxicity, and heart diseases. Oxidative stress further leads to increased ROS production and also delays the cellular processes involved in wound healing. Therefore, existing antibiotic drugs can be replaced with biomaterials such as herbal medicine with high antimicrobial, antiviral, and antioxidant activity. This review paper highlights the antibacterial, antiviral, and radical scavenger (antioxidant) properties of herbal materials. Antimicrobial activity, radical scavenger ability, the potential for antimicrobial, antiviral, and anticancer agents, and efficacy in eliminating bacteria and viruses and scavenging free radicals in herbal materials are discussed in this review. The presented herbal antimicrobial agents in this review include clove, portulaca, tribulus, eryngium, cinnamon, turmeric, ginger, thyme, pennyroyal, mint, fennel, chamomile, burdock, eucalyptus, primrose, lemon balm, mallow, and garlic, which are all summarized.

show abstract

Section: Conclusion and The Future Outlookmentioning

confidence: 99%

Antioxidant, Antimicrobial and Antiviral Properties of Herbal Materials

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Modern science is focusing on validating the traditional claims of this plant through systemic investigations. Different extracts (i.e., acetone, chloroform, ethanol, hexane, methanolic or aqueous extract) and isolated pure metabolites from A. paniculata have been investigated for pharmacological properties, for example, antibacterial, antiviral, antifungal, antiparasitic, choleretic, hypocholesterolemia, anti-inflammatory, anti-hyperglycemic, hepatoprotective, anticancer, immunomodulatory, cardiovascular, antihyperlipidemic, emollient, anti-snake venom, anti-platelet aggregation, anti-fertility, carminative, and antipyretic properties at in vitro and in vivo conditions [41][42][43][44][45][46][47][48][49][50][51][52][53].…”

Section: Introductionmentioning

confidence: 99%

Andrographis paniculata (Burm. f.) Wall. ex Nees: An Updated Review of Phytochemistry, Antimicrobial Pharmacology, and Clinical Safety and Efficacy

Hossain

Urbi

Karuniawati

et al. 2021

Life

139

103

View full text Add to dashboard Cite

Infectious disease (ID) is one of the top-most serious threats to human health globally, further aggravated by antimicrobial resistance and lack of novel immunization options. Andrographis paniculata (Burm. f.) Wall. ex Nees and its metabolites have been long used to treat IDs. Andrographolide, derived from A. paniculata, can inhibit invasive microbes virulence factors and regulate the host immunity. Controlled clinical trials revealed that A. paniculata treatment is safe and efficacious for acute respiratory tract infections like common cold and sinusitis. Hence, A. paniculata, mainly andrographolide, could be considered as an excellent candidate for antimicrobial drug development. Considering the importance, medicinal values, and significant role as antimicrobial agents, this study critically evaluated the antimicrobial therapeutic potency of A. paniculata and its metabolites, focusing on the mechanism of action in inhibiting invasive microbes and biofilm formation. A critical evaluation of the secondary metabolites with the aim of identifying pure compounds that possess antimicrobial functions has further added significant values to this study. Notwithstanding that A. paniculata is a promising source of antimicrobial agents and safe treatment for IDs, further empirical research is warranted.

show abstract

“…Plant polysaccharides also have osteoprotective properties, suppressing osteoclastogenesis and bone resorption by inhibiting RANKL and promoting bone formation [201][202][203][204]. (Table 5) [205][206][207][208]. A recent study showed the effectiveness and safety of andrographolide in reducing pain in individuals suffering from mild-to-moderate knee osteoarthritis [209].…”

Section: Polysaccharides Achyranthes Bidentata Extractsmentioning

confidence: 99%

“…This terpenoid (diterpenoid) is a natural component from Andrographis paniculate , a plant with medicinal properties, such as antioxidant, anti-inflammatory, and anti-arthritic properties ( Table 5 ) [ 205 , 206 , 207 , 208 ]. A recent study showed the effectiveness and safety of andrographolide in reducing pain in individuals suffering from mild-to-moderate knee osteoarthritis [ 209 ].…”

Section: Natural-compound-based Treatments For Oa Therapymentioning

confidence: 99%

Emerging Natural-Product-Based Treatments for the Management of Osteoarthritis

et al. 2021

Self Cite

View full text Add to dashboard Cite

Osteoarthritis (OA) is a complex degenerative disease in which joint homeostasis is disrupted, leading to synovial inflammation, cartilage degradation, subchondral bone remodeling, and resulting in pain and joint disability. Yet, the development of new treatment strategies to restore the equilibrium of the osteoarthritic joint remains a challenge. Numerous studies have revealed that dietary components and/or natural products have anti-inflammatory, antioxidant, anti-bone-resorption, and anabolic potential and have received much attention toward the development of new therapeutic strategies for OA treatment. In the present review, we provide an overview of current and emerging natural-product-based research treatments for OA management by drawing attention to experimental, pre-clinical, and clinical models. Herein, we review current and emerging natural-product-based research treatments for OA management.

show abstract

Andrographis paniculata and Its Bioactive Diterpenoids Against Inflammation and Oxidative Stress in Keratinocytes

Cited by 25 publications

References 33 publications

Antioxidant, Antimicrobial and Antiviral Properties of Herbal Materials

Antioxidant, Antimicrobial and Antiviral Properties of Herbal Materials

Andrographis paniculata (Burm. f.) Wall. ex Nees: An Updated Review of Phytochemistry, Antimicrobial Pharmacology, and Clinical Safety and Efficacy

Emerging Natural-Product-Based Treatments for the Management of Osteoarthritis

Contact Info

Product

Resources

About