Androgens in breast cancer

Grattarola, Renzo; Secreto, Giorgio; Recchione, C; Castellini, Walter

doi:10.1016/0002-9378(74)90545-6

Cited by 40 publications

(8 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have evaluated either urinary oestrogen excretion (Persson & Risholm, 1964;Marmorston et al, 1965;Gronroos & Aho, 1968;Argeulles et al, 1973;Grattarola et , 1974;Thijssen et al, 1975;Morreal et al, 1979) or oestrogen concentrations in the blood (England et al, 1974;McFadyen et al, 1976;Malarkey et al, 1977;Adami et al, 1979;Drafta et al, 1980;Moore et al, 1982;Reed et al, 1983Reed et al, , 1985Secreto et al, 1983;Bruning et al, 1985;Siiteri et al, 1986;Wysowski et al, 1987) of breast cancer cases and controls. These studies have suggested that post-menopausal breast cancer cases have higher endogenous oestrogen levels than controls: five of the seven studies of urinary oestrogen levels found evidence of greater oestrogen excretion in cases (Persson & Risholm, 1964;Marmorston et al, 1965;Arguelles et al, 1973;Grattarola et al, 1974;Morreal et al,1979); of the studies comparing blood levels of E, and E2 in cases and controls, three of five found higher E, (Adami et al, 1979;Drafta et al, 1980;Reed et al, 1983) and eight of 11 found higher E2 levels in cases (England et al, 1974;McFadyen et al, 1976;Malarkey et al, 1977;Drafta et al, 1980;Moore et al, 1982;Reed et al, 1985;Bruning et al, 1985;Siiteri et al, 1986).…”

Section: Discussionmentioning

confidence: 99%

“…These studies have suggested that post-menopausal breast cancer cases have higher endogenous oestrogen levels than controls: five of the seven studies of urinary oestrogen levels found evidence of greater oestrogen excretion in cases (Persson & Risholm, 1964;Marmorston et al, 1965;Arguelles et al, 1973;Grattarola et al, 1974;Morreal et al,1979); of the studies comparing blood levels of E, and E2 in cases and controls, three of five found higher E, (Adami et al, 1979;Drafta et al, 1980;Reed et al, 1983) and eight of 11 found higher E2 levels in cases (England et al, 1974;McFadyen et al, 1976;Malarkey et al, 1977;Drafta et al, 1980;Moore et al, 1982;Reed et al, 1985;Bruning et al, 1985;Siiteri et al, 1986). The results of the present study provide evidence that the higher serum oestrogen concentrations of breast cancer cases are mirrored in the urine by higher urinary oestrogen excretion.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Hormone levels in older women: a study of post-menopausal breast cancer patients and healthy population controls

Bernstein

Ross²,

Pike³

et al. 1990

Br J Cancer

View full text Add to dashboard Cite

Summary Hormone concentrations in blood and total 12 h urine values were compared between 40 postmenopausal women with breast cancer and 40 control women in a study which carefully controlled for the possible confounding effects of age, weight and pregnancy history by individually matching cases and controls on these factors. Breast cancer cases had received only surgical treatment for their localised disease, which was diagnosed from 1 to 9 years before hormonal evaluation. Cases had 15% higher serum oestradiol levels (P=0.02), 40% more urinary oestradiol (P=0.03) and 44% more urinary oestriol (P=0.04) than control women. Cases also had higher levels of serum and urinary oestrone, but these differences were not statistically significant. The percentages of serum oestradiol not bound to albumin or sex-hormone binding globulin did not differ between cases and controls, nor were there statistically significant differences in the serum levels of prolactin, sex-hormone binding globulin or dehydroepiandrosterone sulphate. These results provide further support for the hypothesis that breast cancer risk is determined in part by post-menopausal serum oestrogen concentration.There is a substantial body of epidemiological, experimental and clinical evidence for a role of oestrogens in the aetiology of female breast cancer (Henderson et al., 1988). In premenopausal women, the major source of endogenous oestrogens is the ovary. Menopause signals a marked decline in the amount of circulating oestrogens and this decline is at least part of the explanation for the decreased risk of breast cancer associated with early menopause (Trichopoulos et al., 1972). Although breast cancer incidence continues to rise after menopause in US and European women, the rate of increase in breast cancer incidence decreases substantially. In post-menopausal women, the major source of oestrogen is the peripheral conversion of androstenedione in fat tissue (Grodin et al., 1973). This offers the most probable explanation for the association of obesity with increased risk of breast cancer in post-menopausal women (Lubin et al., 1985).In women, 40-50% of plasma oestradiol (E2) is bound to sex hormone-binding globulin (SHBG) and all but 2-4% of the remainder is bound to albumin (Anderson, 1974). With the development of relevant laboratory technology, attention has focused on evaluating whether the free, non-protein bound fraction of plasma E2 is higher in women with breast cancer than in other women, as free E2 is considered to be freely diffusible into cells and biologically available to receptors in target tissues (Siiteri, 1980); this may also be true of the non-SHGB bound E2 (Pardridge, 1986). This would further explain the effect of body weight on breast cancer risk in older women as increased weight is not only associated with higher post-menopausal oestrogen levels but also with reduced levels of SHBG and, therefore, with greater 'tissue availability' of oestrogens (Siiteri et al., 1981).A number of studies have compared endogenous oestrogen and ...

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Hormone levels in older women: a study of post-menopausal breast cancer patients and healthy population controls

Bernstein

Ross²,

Pike³

et al. 1990

Br J Cancer

View full text Add to dashboard Cite

show abstract

“…It has also been shown that these patients have significantly higher levels of the metabolite than women with endometrial hyperplasia alone-both before and after the menopause (Grattarola, 1967(Grattarola, , 1970Grattarola et al, 1974). It was postulated that the increased androgen production probably originated from the ovaries.…”

mentioning

confidence: 99%

Concentration of Testosterone Glucuronide in Urine from Women with Breast Tumours

Jones¹

1977

Br J Cancer

View full text Add to dashboard Cite

“…Such efforts produced inconsistent results. Most reports found no association (22)(23)(24), although quite a few observed a modest, positive relationship with estradiol (13,21,(25)(26)(27)(28)(29)(30).…”

mentioning

confidence: 97%

“…In the late 1960s and 1970s, a number of hospital-based case-control studies of the relationship between urinary and circulating estrogens and breast cancer (11)(12)(13)(14)(15)(16)(17)) generated enthusiasm and were followed by a wave of similar efforts (7), most notably at the Harvard School of Public Health (12,(18)(19)(20)(21). Such efforts produced inconsistent results.…”

mentioning

confidence: 99%

Endogenous estrogens and breast cancer risk: the case for prospective cohort studies.

Toniolo

1997

Environ Health Perspect

View full text Add to dashboard Cite

show abstract

Androgens in breast cancer

Cited by 40 publications

References 24 publications

Hormone levels in older women: a study of post-menopausal breast cancer patients and healthy population controls

Hormone levels in older women: a study of post-menopausal breast cancer patients and healthy population controls

Concentration of Testosterone Glucuronide in Urine from Women with Breast Tumours

Endogenous estrogens and breast cancer risk: the case for prospective cohort studies.

Contact Info

Product

Resources

About