Androgenic potentials of aqueous extract of Massularia acuminata (G. Don) Bullock ex Hoyl. stem in male Wistar rats

Yakubu, Musa Toyin; Akanji, Musbau Adewumi; Oladiji, Adenike Temidayo; Adesokan, AA

doi:10.1016/j.jep.2008.05.020

Cited by 84 publications

(64 citation statements)

References 23 publications

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“…Increasing of testosterone of serum by the aqueous extract might be responsible for the enhanced sexual behaviour in the animals [23]. Extract prolonged the ejaculatory latency in male rats, indicating an increase of ejaculatory threshold [24]. These findings support the use of these medicinal plant for the treatment of premature ejaculation in traditional medicine.…”

Section: Discussionsupporting

confidence: 58%

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Aphrodisiac Activity of Aqueous Extract of <i>Phoenix dactylifera</i> Pollen in Male Rats

Abedi¹,

Parviz²,

Karimian³

et al. 2013

ASM

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Aim of study: Ancient literature alluded to the use of a number of plants/preparations as sex enhancer. One of such botanicals is Phoenix dactylifera in which the pollen grain has been acclaimed to be used as an aphrodisiac. However, the validity has not been scientifically tested. Dopamine is known to facilitate male sexual function. Therefore, the present study was undertaken to evaluate the effect of aqueous extract of Phoenix dactylifera pollen on the sexual behavior of male rats and to measure of serum Estradiol and Testostrone. Also, dopamine transmission in the nucleus accumbence (NAc) was studied in male rats using in vivo microdialysis. Methods and Materials: sixty male rats were randomized into 6 groups (A-F). Group A received 0.2 ml of Normal Saline mixed with Dimethyl Sulphate (DMSO), while groups B-F were injected same volume containing 35 mg/kg, 70 mg/kg, 105 mg/kg, 140 mg/kg and 350 mg/kg of DPP extract, respectively. Sexual behavioral parameters including mounting, intromission and ejaculation frequencies and latencies were recorded in male rats one hour after injection of extract by mating with a receptive female (1:1). The male serum testosterone and estradiol concentrations were also determined. Results: All doses stimulated male sexual behavior. Extract significantly increased mount, ejaculation, intromission frequencies and ejaculation latency in comparison to controlled ones (p < 0.001). Mount and intromission latencies significantly reduced (p < 0.001). Maximum effect was observed in dose 140 mg/kg. This extract was found to enhance Testestrone, Estradiol and the orientation of males toward female ones by increasing mounting and ano-genital investigatory behavior. Conclusions: Data from this study identified that the aqueous extract of Phoenix dactylifera pollen grain enhanced sexual behaviour in male rats. The improved sexual appetitive behaviour in male rats may be attributed, to the alkaloids, saponins, and or flavonoids since these phytochemicals has engorgement, androgen enhancing. Also, our findings support the traditional use of this plant as acclaimed aphrodisiac and for the treatment of pre-ejaculation and impotency.

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Section: Discussionsupporting

confidence: 58%

“…These agents can increase sexual behavior. They stimulate endogenous testosterone levels probably by raising the level of luteinizing hormones (LH) [24][25][26]. Following adequate erection and activity of muscles, intromission is possible and increasing of IF by the extract show the activation of penile erection mechanism.…”

Section: Discussionmentioning

confidence: 99%

Aphrodisiac Activity of Aqueous Extract of <i>Phoenix dactylifera</i> Pollen in Male Rats

Abedi¹,

Parviz²,

Karimian³

et al. 2013

ASM

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“…The rats were further dissected and the liver, kidney, heart, lungs and spleen excised, freed of fat, blotted with clean tissue paper and then weighed. The organ-to-body weight ratios were determined according to the expression described by Yakubu et al [17] .…”

Section: Preparation Of Serum and Isolation Of Organsmentioning

confidence: 99%

Toxicity profile of ethanolic extract of Azadirachta indica stem bark in male Wistar rats

Ashafa

Orekoya

Yakubu

2012

Asian Pacific Journal of Tropical Biomedicine

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“…(testosterone) and negative control (normal feed) (Yakubu et al, 2008). The change in mount latency during five-day period showed a similar trend for all the test groups.…”

Section: Resultsmentioning

confidence: 54%

Aphrodisiac properties of some Zimbabwean medicinal plants formulations

Gundidza¹,

Mmbengwa²,

Magwa³

et al. 2009

Afr. J. Biotechnol.

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The aim of the present study was to determine the effects of formulations composed of Mondia whitei, Ekebergia capansis, aloe tincture (Aloe exelsa) and pumpkin seed (Cucurbita pepo) on sexual behaviour of inexperienced male rats. Male rats were treated orally with ethanol extracts of M. whitei and E. capensis, aloe tincture (from aloe juice) and pumpkin seed powder. The sexual behaviour of the rats treated with extracts was compared with those treated with 100 µg of testosterone as the positive control and those receiving normal rat feed as negative control. The receptivity of the females was rendered homogeneous with daily dose of estadiol benzoate. The sexual behaviour of the rats were observed over one ejaculatory phase for five consecutive days. The results showed a dose dependent increase in sexual arousability (decreased mounting latency), copulatory efficiency (decreased intercoupulatory interval) and improved sexual sensation (increased in neuromotor activity) for the rats treated with M. whitei and E. capensis, aloe and pumpkin seeds showing an increase in sexual performance in terms of intromissions and ejaculatory latency which also improved sexual sensation and coupulatory efficiency. The formulations of plants under investigation showed significant aphrodisiac properties.

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Androgenic potentials of aqueous extract of Massularia acuminata (G. Don) Bullock ex Hoyl. stem in male Wistar rats

Cited by 84 publications

References 23 publications

Aphrodisiac Activity of Aqueous Extract of <i>Phoenix dactylifera</i> Pollen in Male Rats

Aphrodisiac Activity of Aqueous Extract of <i>Phoenix dactylifera</i> Pollen in Male Rats

Toxicity profile of ethanolic extract of Azadirachta indica stem bark in male Wistar rats

Aphrodisiac properties of some Zimbabwean medicinal plants formulations

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Androgenic potentials of aqueous extract of Massularia acuminata (G. Don) Bullock ex Hoyl. stem in male Wistar rats

Cited by 84 publications

References 23 publications

Aphrodisiac Activity of Aqueous Extract of &lt;i&gt;Phoenix dactylifera&lt;/i&gt; Pollen in Male Rats

Aphrodisiac Activity of Aqueous Extract of &lt;i&gt;Phoenix dactylifera&lt;/i&gt; Pollen in Male Rats

Toxicity profile of ethanolic extract of Azadirachta indica stem bark in male Wistar rats

Aphrodisiac properties of some Zimbabwean medicinal plants formulations

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Product

Resources

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Aphrodisiac Activity of Aqueous Extract of <i>Phoenix dactylifera</i> Pollen in Male Rats

Aphrodisiac Activity of Aqueous Extract of <i>Phoenix dactylifera</i> Pollen in Male Rats