Androgenetic Alopecia

Abstract

Androgenetic alopecia (AGA), or male pattern hair loss, affects approximately 50% of the male population. AGA is an androgen-related condition in genetically predisposed individuals. There is no treatment to completely reverse AGA in advanced stages, but with medical treatment (eg, finasteride, minoxidil, or a combination of both), the progression can be arrested and partly reversed in the majority of patients who have mild to moderate AGA. Combination with hair restoration surgery leads to best results in suitable candidates. Physicians who specialize in male health issues should be familiar with this common condition and all the available approved treatment options.

Adipose derived stem cell based therapies or male/female pattern hair loss

“…Individuals with Alopecia Androgenetica, however, experience a decrease in the duration of anagen phase as the hair cycle proceeds [4]. As the anagen phase decreases, the proportion of hair follicles in the telogen phase increases, inducing hair growth that is more fine [4]. Additionally, an increase in the turnover time between hair shedding and the anagen (growth) phase diminishes hair density at the scalp [4].…”

“…Typical anagen to telogen ratio in an individual experiencing regular hair growth is established at 9:1 4. Individuals with Alopecia Androgenetica, however, experience a decrease in the duration of anagen phase as the hair cycle proceeds [4]. As the anagen phase decreases, the proportion of hair follicles in the telogen phase increases, inducing hair growth that is more fine [4].…”

“…The 26 year long anagen phase is classified as the growing period, whereas the catagen phase of regression lasts 23 weeks and is followed by a 12 week telogen resting phase [4]. Typical anagen to telogen ratio in an individual experiencing regular hair growth is established at 9:1 4.…”

“…Alopecia Androgenetica can be characterized by the gradual thinning of hair emphasized at the crown and frontal scalp, attributed to interactions among various genetic and endocrine factors [3,4]. Individuals impacted by Alopecia Androgenetica are subject to general psychological trauma, as many report a decreased quality of life, lack of self-confidence, and limited social contacts [4][5][6].…”

Effect of Charge Carrier Lipid on Skin Penetration, Retention, and Hair Growth of Topically Applied Finasteride-Containing Liposomes

“…Although there is no treatment to completely reverse androgenetic alopecia in advanced stage, treatment with minoxidil or fi nasteride (or combination of both) can slow down and partly reverse the progression in the majority of patients who have mild to moderate stage (Otberg et al, 2007). The US Food and Drug Administration approved topical solution of minoxidil and low-dose fi nasteride (FNS) for the treatments of the hair loss and androgenetic alopecia.…”