Adipose derived stem cell based therapies or male/female pattern hair loss

Lockhart, Ryan A.; Hakakian, Cloe S.; Birnbaum, Zoe E.; Aronowitz, Joel A.

doi:10.15761/jscrm.1000108

Cited by 1 publication

(1 citation statement)

References 11 publications

(21 reference statements)

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“…There has been a relative lack of new therapeutic options for the treatment of hair loss in the last 30 years. While a significant amount of research and capital have been invested in the sector, investigated treatments have not proven effective enough to replace current treatment modalities [12].…”

Section: Discussionmentioning

confidence: 99%

Autologous Adipose Derived Stem Cell versus Platelet Rich Plasma Injection in the Treatment of Androgentic Alopecia: Efficacy, Side Effects and Safety

Kadry¹,

El-Kheir²,

Shalaby³

et al. 2018

J Clin Exp Dermatol Res

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Background: Platelet Rich Plasma (PRP) is based on the release of growth factors stimulating the initiation/ extension of anagen phase as well as promoting vascularization, Adipose Derived Stem Cell (AT-ADSCs) treatment were recently introduced as an alternative potential therapeutic application for hair growth. Objective: The aim of this study was to assess the efficacy side effects and safety of AT-ASCs and PRP in the treatment of androgentic alopecia. Patients and methods: Sixty randomized patients were treated by PRP, and AT-ASCs. Each patient was evaluated, and each lesion was treated by those modalities, patients received three sessions with one month interval for 3 months, follow up after 3 months. Results: A highly significant improvement <0.001 in terminal hair count of AT-ASCs group evaluated by videodermoscopy assessment of AGA. That were confirmed by highly significant improvement in intermediate hair count and mean caliber (<0.001) associated with high incidence of side effects especially headache and erythema. In contrast, PRP group showed significant improvement 0.037 in terminal hair count and non-significant improvement in intermediate hair count and of mean caliber with minimum side effects. AT-ASCs showed a significant improvement in terminal hair count than PRP, Highly significant improvement in Intermediate hair count and hair caliber. Also, side effects of AT-ASCs showed highly significant pain, headache and erythema but no serious adverse events. Conclusion: Our study suggests that the There was significant improvement in AGA after PRP and highly significant after AT-ASCs therapy with significant difference of ADSC in terminal hair count and highly significant in caliber. Both modalities could effectively and safely be used to treat AGA.

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Section: Discussionmentioning

confidence: 99%