Androgenetic alopecia in men and women

Sinclair, Rodney; Dawber, R.P.R.

doi:10.1016/s0738-081x(00)00128-0

Cited by 81 publications

(97 citation statements)

References 76 publications

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“…The combination of topical minoxidil with topical tretinoin has been proposed but is limited by irritation of the scalp, and the benefits have not been substantiated in large studies [17, 18]. …”

Section: Discussionmentioning

confidence: 99%

An Open, Randomized, Comparative Study of Oral Finasteride and 5% Topical Minoxidil in Male Androgenetic Alopecia

Arca¹,

Açıkgöz²,

Taştan³

et al. 2004

Dermatology

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Background and Aim: Androgenetic alopecia (AGA) is undoubtedly the most common form of hair loss in males. It is a condition which may cause cosmetic and psychosocial problems in androgen-dependent cases. In this open, randomized and comparative study we evaluated the efficacy of oral finasteride and 5% topical minoxidil treatment for 12 months in 65 male patients with mild to severe AGA. Methods: We randomly assigned 40 (61.53%) patients to receive 1 mg/day oral finasteride for 12 months, and 25 (38.47%) patients applied 5% topical minoxidil solution twice daily for 12 months. Results: There were no significant differences between the 2 groups considering age, age of onset of hair loss, family history and type of hair loss (p > 0.05). In the clinical evaluation at the endpoint of treatment, the clinical cure rates (i.e. increased intensity of hair) were 80% (32/40) for the oral finasteride group and 52% (13/25) for the 5% topical minoxidil group. Encountered side effects were all mild, and there was no need to stop the treatment. In the group given oral finasteride, side effects were noted in 7 patients: 6 patients suffered from loss of libido, and 1 patient had an increase in other body hairs; irritation of the scalp was seen in 1 patient in the group administered 5% minoxidil. These adverse events disappeared as soon as the treatment was stopped. The laboratory data on both drug groups did not show any statistically or clinically significant intragroup changes from baseline values to the endpoint (p > 0.05), except the level of serum total testosterone which was increased, and free testosterone and serum prostate-specific antigen in the finasteride group which were statistically decreased from baseline values to the endpoint (p < 0.05). Conclusion: In this comparative study of systemic finasteride and topical minoxidil, it was concluded that both drugs were effective and safe in the treatment of mild to severe AGA, although oral finasteride treatment was more effective (p < 0.05). Adverse events were not considered important either, and these side effects disappeared as soon as the treatment was stopped.

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Section: Discussionmentioning

confidence: 99%

An Open, Randomized, Comparative Study of Oral Finasteride and 5% Topical Minoxidil in Male Androgenetic Alopecia

Arca¹,

Açıkgöz²,

Taştan³

et al. 2004

Dermatology

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“…A group of people exposed to the same cause do not suffer the same kind of hair loss, if you try to treat one cause, hair roots being sensitive may fall prey to hair loss from another cause. We should consider the fact that the androgens or DHT levels in most hair loss patients are normal and not raised [18,23,24] . There are several persons with similar androgen levels who do not have any hair loss at all.…”

Section: Hypothesis and The Proposed Perspectivementioning

confidence: 99%

“…Now numerous other types of thinning and hair loss have been identified as mimicing AGA [22][23][24][25] . Therefore we found the need to develop a new category of description and classification defined as diffuse unpatterned hair loss (DUPA) [8,26] .…”

Section: Introductionmentioning

confidence: 99%

Controlled clinical trial for evaluation of hair growth with low dose cyclical nutrition therapy in men and women without the use of finasteride

Rajput¹

2017

PAR

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“…Each of these approaches, when interpreted with the comprehensive clinical picture, can provide valuable insights into patient diagnosis, treatment and monitoring 7 .More recent studies have accumulated evidence that use of dermoscopy of hair and scalp (trichoscopy) in the clinical evaluation of hair disorders improves diagnostic capability beyond simple clinical inspection [8][9][10][11] . Without treatment, AGA takes a chronic progressive course with an average hair loss of 5-6 % annually with great inter individual variability 12,13 . Minoxidil increases the duration of anagen growth phase and gradually enlarges miniaturized hair follicles (vellus hairs) into mature terminal hairs 14 .…”

Section: % On the Basis Of Dermoscopic Analysis In Androgenetic Alomentioning

confidence: 99%

Comparative Study of Efficacy of Topical Minoxidil 5% and Combination of Topical Minoxidil 5%, Topical Azelaic Acid 1.5% and Topical Tretinoin 0.01% on the Basis of Dermoscopic Analysis in Androgenetic Alopecia

Gugle

Jadhav

Kote

et al. 2015

MVP Journal of Medical Science

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Background: Androgenetic alopecia (AGA) more commonly known as male pattern baldness affects up to 50% of men worldwide. Tretinoin prolongs anagen phase and increases percutaneous absorption of minoxidil three fold. Azelaic acid is an inhibitor of 5 alpha reductase and could be an effective agent in the treatment of androgen related pathology of human skin. Aims and Objective: 1) To study the efficacy of topical minoxidil 5% in treatment of androgenetic alopecia. 2) To study the efficacy of combination of topical minoxidil 5%, topical azelaic acid 1.5% and topical tretinoin 0.01% in treatment of androgenetic alopecia. 3) To compare the efficacy of foresaid topical preparation in treatment of androgenetic alopecia Setting: Outpatient department of Dermatology, Venerology Leprology of a tertiary health care centre with an attached medical college. Material and methods: Topical minoxidil 5 % lotion was used in 23 (50%) patients of the present study. Combination of topical minoxidil 5%, azelaic acid 1.5 % and tretinoin 0.01 % lotion was used in 23 (50 %) patients of the present study. Statistical analysis used: Epi info version 7. Results: There was statistically significant increase in hair number and thickness after treatment in both the groups. The comparison of the increase of hair number and thickness was statistically insignificant. Conclusions: Topical Minoxidil 5% is equally effective to combination of topical Minoxidil 5%, azelaic acid 1.5% and tretinoin 0.01% in treatment of androgenetic alopecia.

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Androgenetic alopecia in men and women

Cited by 81 publications

References 76 publications

An Open, Randomized, Comparative Study of Oral Finasteride and 5% Topical Minoxidil in Male Androgenetic Alopecia

An Open, Randomized, Comparative Study of Oral Finasteride and 5% Topical Minoxidil in Male Androgenetic Alopecia

Controlled clinical trial for evaluation of hair growth with low dose cyclical nutrition therapy in men and women without the use of finasteride

Comparative Study of Efficacy of Topical Minoxidil 5% and Combination of Topical Minoxidil 5%, Topical Azelaic Acid 1.5% and Topical Tretinoin 0.01% on the Basis of Dermoscopic Analysis in Androgenetic Alopecia

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