Controlled clinical trial for evaluation of hair growth with low dose cyclical nutrition therapy in men and women without the use of finasteride

Rajput, Rajendrasingh

doi:10.20517/2347-9264.2017.57

Cited by 9 publications

(9 citation statements)

References 54 publications

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“…In our study, we a found a mean improvement of 22.96% in hair shaft thickness, which is near the value of 24% reported by Rajput [17]. However, he studied a different modality of treatment.…”

Section: Comparison Of Mean Hair Shaft Thickness Before and After Tre...supporting

confidence: 72%

Evaluation of hair regrowth in men with androgenetic alopecia treated with autologous platelet-rich plasma

Potdar¹,

Gosavi²,

Chavan³

et al. 2022

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Introduction: Androgenetic alopecia, the most common form of hair loss in men, is associated with significant distress and lowered self-esteem. Various medical, surgical, and miscellaneous therapeutic modalities are available for management. Autologous platelet-rich plasma has yielded encouraging results in androgenetic alopecia. Objective: To evaluate the application of easily available techniques to prepare autologous platelet-rich plasma and study its effect in promoting hair regrowth. Material and methods: After ethical clearance, 30 men were enrolled in this prospective, interventional, non-randomized study. After baseline evaluation, autologous platelet-rich plasma was injected on pre-anaesthetised scalp. 20 ml of whole blood yielded 2 ml of platelet-rich plasma by double centrifugation. A 4-5 times increased platelet concentration from baseline was obtained. Six sessions done at 3-week intervals. The last follow-up was taken 3 months after the last platelet-rich plasma session. An evaluator assessed the improvement by pre-and post-treatment photographs, trichoscopic parameters, and basic and specific classification of androgenetic alopecia. The patient subjective score was also recorded. Results:The mean age of participants was 27.47 years. The most responsive area was frontal (p = 0.001). The hair-shaft thickness improved by a mean of 45.11%. The mean number of hairs per follicular unit increased by 31.79%. A mean gain of 6.53 follicular units was obtained. 53.3% of patients sustained benefits from platelet-rich plasma. Evaluator assessment score overall was +5 on the Jaeschke scale of -7 to +7. The overall patient subjective score was 2 on a scale from 0 to 4. Conclusions: Autologous platelet-rich plasma causes an increase in hair shaft thickness and numbers of hairs per follicular unit in men with androgenetic alopecia with no major side effects. It can be prepared easily in the dermatological office setting.

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Section: Comparison Of Mean Hair Shaft Thickness Before and After Tre...supporting

confidence: 72%

Evaluation of hair regrowth in men with androgenetic alopecia treated with autologous platelet-rich plasma

Potdar¹,

Gosavi²,

Chavan³

et al. 2022

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“…The approach has been found to be beneficial in hair loss management and achieving new hair growth in various indications [46,53,[101][102][103][104][105]. A clinical trial with 100 patients in each group, having a control group and treatment group comparing 2% minoxidil plus finasteride in men and only 2% minoxidil in women has been published earlier [106]. The density and calibre were measured by tattooed, computerized trichoscopy analysis.…”

Section: Comprehensive Low Dose Nutrient Therapymentioning

confidence: 99%

A Scientific Hypothesis on the Role of Nutritional Supplements for Effective Management of Hair Loss and Promoting Hair Regrowth

Rajput¹

2018

jnhfs

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Our quest for establishing a cause and effect relationship has lead us to accept that only androgens and DHT causes hair loss. However there are various other internal and external factors resulting in hair loss due to dysregulation of the hair growth cycles. There are non hormonal factors that influence and carry out metabolic interactions maintaining a cellular environment to ensure the intricate balance of hair growth cycles. Oxidative stress generated by ROS (Reactive Oxygen Species) from external exposure to pollution, smoking, pesticides in foods, contamination of soil, water, etc. as well as excessive ROS formation due to internal metabolic derangements, can lead to hair loss. Vitamin and mineral deficiencies have been clinically detected in hair loss patients and are known to alter the immune response. Though the prevalence of nutritional deficiencies is common these are covert deficiencies. The nutrient deficiencies cannot always be detected clinically as the deficiencies are masked and compensated by self regulating processes of redistributing the utilization of nutrients in the body, arresting hair growth during stress, sickness, exertion, recovery, etc. which we know as telogen effluvium, and by novel mechanisms like autophagy. In deficiency states body conserves the nutrients by restricting hair growth. It is worthy to note that apparent deficiency of a single nutrient has a cascading effect on optimum utilization of multiple other nutrients and functioning of other body systems. When we desire to stimulate or ensure hair growth it is logical to ensure a supply of building blocks, which are the necessary nutrients, in order to support cell division and growth. We have been investigating hair loss all the time. Let us now change our perspective and direct our efforts on how to strengthen the hair roots to withstand the onslaught of damage and enhance hair growth. In the present review, a low dose comprehensive cyclical nutrient therapy, for hair growth utilized in our practice is included. Here we propose the hypothesis and discuss the scientific basis and mechanism of how to achieve hair growth with the use of nutritional supplements.

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“…The cyclical nutrition therapy regimen used is described in table 1. The regimen has been previously published by the author (4,5). Group II and group III did not receive minoxidil or any other scalp application.…”

Section: The Comparative Clinical Trialmentioning

confidence: 99%

“…The approach also avoids possibility of overdose and can be followed for a longer period of time. Hair loss under a variety of indications and causes has been treated with this cyclical nutrition therapy (70,71,72,73,74,75).…”

Section: High Doses Of Iron Are Not Beneficialmentioning

confidence: 99%

Controversy on the role of iron and a clinical trial with intermittent iron and nutritional supplements in hair loss management

2018

IJFNR

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Controlled clinical trial for evaluation of hair growth with low dose cyclical nutrition therapy in men and women without the use of finasteride

Cited by 9 publications

References 54 publications

Evaluation of hair regrowth in men with androgenetic alopecia treated with autologous platelet-rich plasma

Evaluation of hair regrowth in men with androgenetic alopecia treated with autologous platelet-rich plasma

A Scientific Hypothesis on the Role of Nutritional Supplements for Effective Management of Hair Loss and Promoting Hair Regrowth

Controversy on the role of iron and a clinical trial with intermittent iron and nutritional supplements in hair loss management

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